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6NJN

Architecture and subunit arrangement of native AMPA receptors

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0006811biological_processmonoatomic ion transport
A0015276molecular_functionligand-gated monoatomic ion channel activity
A0016020cellular_componentmembrane
A0038023molecular_functionsignaling receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0006811biological_processmonoatomic ion transport
B0015276molecular_functionligand-gated monoatomic ion channel activity
B0016020cellular_componentmembrane
B0038023molecular_functionsignaling receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0006811biological_processmonoatomic ion transport
C0015276molecular_functionligand-gated monoatomic ion channel activity
C0016020cellular_componentmembrane
C0038023molecular_functionsignaling receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0006811biological_processmonoatomic ion transport
D0015276molecular_functionligand-gated monoatomic ion channel activity
D0016020cellular_componentmembrane
D0038023molecular_functionsignaling receptor activity
F0005245molecular_functionvoltage-gated calcium channel activity
F0005246molecular_functioncalcium channel regulator activity
F0005262molecular_functioncalcium channel activity
F0005515molecular_functionprotein binding
F0005891cellular_componentvoltage-gated calcium channel complex
F0006612biological_processprotein targeting to membrane
F0006816biological_processcalcium ion transport
F0007528biological_processneuromuscular junction development
F0009986cellular_componentcell surface
F0014069cellular_componentpostsynaptic density
F0016020cellular_componentmembrane
F0016247molecular_functionchannel regulator activity
F0019226biological_processtransmission of nerve impulse
F0032281cellular_componentAMPA glutamate receptor complex
F0034702cellular_componentmonoatomic ion channel complex
F0035255molecular_functionionotropic glutamate receptor binding
F0036477cellular_componentsomatodendritic compartment
F0042391biological_processregulation of membrane potential
F0043005cellular_componentneuron projection
F0044300cellular_componentcerebellar mossy fiber
F0045202cellular_componentsynapse
F0050877biological_processnervous system process
F0051592biological_processresponse to calcium ion
F0051899biological_processmembrane depolarization
F0051968biological_processpositive regulation of synaptic transmission, glutamatergic
F0060081biological_processmembrane hyperpolarization
F0060082biological_processeye blink reflex
F0070588biological_processcalcium ion transmembrane transport
F0098685cellular_componentSchaffer collateral - CA1 synapse
F0098686cellular_componenthippocampal mossy fiber to CA3 synapse
F0098839cellular_componentpostsynaptic density membrane
F0098943biological_processneurotransmitter receptor transport, postsynaptic endosome to lysosome
F0098970biological_processpostsynaptic neurotransmitter receptor diffusion trapping
F0098978cellular_componentglutamatergic synapse
F0099072biological_processregulation of postsynaptic membrane neurotransmitter receptor levels
F0099590biological_processneurotransmitter receptor internalization
F0099645biological_processneurotransmitter receptor localization to postsynaptic specialization membrane
F1904510biological_processpositive regulation of protein localization to basolateral plasma membrane
F2000311biological_processregulation of AMPA receptor activity
H0005245molecular_functionvoltage-gated calcium channel activity
H0005246molecular_functioncalcium channel regulator activity
H0005262molecular_functioncalcium channel activity
H0005515molecular_functionprotein binding
H0005891cellular_componentvoltage-gated calcium channel complex
H0006612biological_processprotein targeting to membrane
H0006816biological_processcalcium ion transport
H0007528biological_processneuromuscular junction development
H0009986cellular_componentcell surface
H0014069cellular_componentpostsynaptic density
H0016020cellular_componentmembrane
H0016247molecular_functionchannel regulator activity
H0019226biological_processtransmission of nerve impulse
H0032281cellular_componentAMPA glutamate receptor complex
H0034702cellular_componentmonoatomic ion channel complex
H0035255molecular_functionionotropic glutamate receptor binding
H0036477cellular_componentsomatodendritic compartment
H0042391biological_processregulation of membrane potential
H0043005cellular_componentneuron projection
H0044300cellular_componentcerebellar mossy fiber
H0045202cellular_componentsynapse
H0050877biological_processnervous system process
H0051592biological_processresponse to calcium ion
H0051899biological_processmembrane depolarization
H0051968biological_processpositive regulation of synaptic transmission, glutamatergic
H0060081biological_processmembrane hyperpolarization
H0060082biological_processeye blink reflex
H0070588biological_processcalcium ion transmembrane transport
H0098685cellular_componentSchaffer collateral - CA1 synapse
H0098686cellular_componenthippocampal mossy fiber to CA3 synapse
H0098839cellular_componentpostsynaptic density membrane
H0098943biological_processneurotransmitter receptor transport, postsynaptic endosome to lysosome
H0098970biological_processpostsynaptic neurotransmitter receptor diffusion trapping
H0098978cellular_componentglutamatergic synapse
H0099072biological_processregulation of postsynaptic membrane neurotransmitter receptor levels
H0099590biological_processneurotransmitter receptor internalization
H0099645biological_processneurotransmitter receptor localization to postsynaptic specialization membrane
H1904510biological_processpositive regulation of protein localization to basolateral plasma membrane
H2000311biological_processregulation of AMPA receptor activity
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH
ChainResidueDetails
JTYR193-HIS199

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues160
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
FMET10-THR30
FSER104-ALA124
FILE134-ILE154
FPHE182-ILE202
HMET10-THR30
HSER104-ALA124
HILE134-ILE154
HPHE182-ILE202

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903
ChainResidueDetails
FSER253
HSER253
DTYR523-VAL543
DLEU596-TYR616

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:O88602
ChainResidueDetails
FTYR271
HTYR271
CGLU813-ILE862
DSER544-GLU570
DASP590-SER595
DGLU813-ILE862

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by PKA => ECO:0000250|UniProtKB:O88602
ChainResidueDetails
FTHR321
HTHR321

site_idSWS_FT_FI5
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
FASN48
HASN48

site_idSWS_FT_FI6
Number of Residues20
DetailsTRANSMEM: Helical; Name=M4 => ECO:0000250
ChainResidueDetails
CVAL792-ILE812
DVAL792-ILE812

site_idSWS_FT_FI7
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:19003990, ECO:0000269|PubMed:20199107, ECO:0007744|PDB:3DLN, ECO:0007744|PDB:3M3F, ECO:0007744|PDB:3M3K
ChainResidueDetails
CPRO478
DSER654
DTHR655
DGLU705
CTHR480
CARG485
CSER654
CTHR655
CGLU705
DPRO478
DTHR480
DARG485

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q9Z2W9
ChainResidueDetails
CTYR845
CTYR855
BLYS752
DARG453
DARG660
DLYS752

site_idSWS_FT_FI9
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:P23819
ChainResidueDetails
CCYS589
DILE633

site_idSWS_FT_FI10
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:Q9Z2W9
ChainResidueDetails
CCYS815
DSER662

site_idSWS_FT_FI11
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
CASN35
CASN380
CASN380

site_idSWS_FT_FI12
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21317871, ECO:0007744|PubMed:24090084
ChainResidueDetails
CASN238
BSER842
BSER859
DSER839
DSER842
DSER859

site_idSWS_FT_FI13
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21317871
ChainResidueDetails
CASN352
DTYR855
AASN239
AASN345

site_idSWS_FT_FI14
Number of Residues4
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250
ChainResidueDetails
BCYS589
BCYS815
DCYS589
DCYS815

site_idSWS_FT_FI15
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21317873
ChainResidueDetails
BASN235
DASN235

site_idSWS_FT_FI16
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19946266, ECO:0000269|PubMed:21317873, ECO:0000269|PubMed:25103405
ChainResidueDetails
BASN349
DASN349

site_idSWS_FT_FI17
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN385
BASN392
DASN385
DASN392

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PDB entries from 2024-11-06

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