Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6NJJ

Crystal Structure of the PDE4D Catalytic Domain and UCR2 Regulatory Helix with BPN14770

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
A	0007165	biological_process	signal transduction
A	0008081	molecular_function	phosphoric diester hydrolase activity
B	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
B	0007165	biological_process	signal transduction
B	0008081	molecular_function	phosphoric diester hydrolase activity
C	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
C	0007165	biological_process	signal transduction
C	0008081	molecular_function	phosphoric diester hydrolase activity
D	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
D	0007165	biological_process	signal transduction
D	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue ZN A 701

Chain	Residue
A	HIS330
A	HIS366
A	ASP367
A	ASP484
A	HOH805
A	HOH823

site_id	AC2
Number of Residues	6
Details	binding site for residue MG A 702

Chain	Residue
A	HOH869
A	HOH894
A	HOH907
A	ASP367
A	HOH807
A	HOH823

site_id	AC3
Number of Residues	14
Details	binding site for residue KR7 A 703

Chain	Residue
A	TYR325
A	MET439
A	ASN487
A	TYR495
A	TRP498
A	THR499
A	ILE502
A	GLN535
A	PHE538
A	PHE599
A	THR603
A	HOH836
A	HOH875
A	HOH880

site_id	AC4
Number of Residues	11
Details	binding site for residue BTB A 704

Chain	Residue
A	HIS318
A	GLU409
A	ZN705
A	HOH817
A	HOH828
A	HOH892
C	HIS320
C	ASP322
C	ASP369
C	PRO371
C	ARG512

site_id	AC5
Number of Residues	2
Details	binding site for residue ZN A 705

Chain	Residue
A	HIS318
A	BTB704

site_id	AC6
Number of Residues	6
Details	binding site for residue SO4 A 706

Chain	Residue
A	HIS271
A	VAL272
A	PHE273
A	ARG274
A	LEU494
A	GLN497

site_id	AC7
Number of Residues	6
Details	binding site for residue EDO A 707

Chain	Residue
A	LEU341
A	THR344
A	TRP550
A	ASP557
A	ILE561
A	HOH866

site_id	AC8
Number of Residues	6
Details	binding site for residue ZN B 701

Chain	Residue
B	HIS330
B	HIS366
B	ASP367
B	ASP484
B	HOH829
B	HOH830

site_id	AC9
Number of Residues	6
Details	binding site for residue MG B 702

Chain	Residue
B	ASP367
B	HOH817
B	HOH829
B	HOH847
B	HOH874
B	HOH883

site_id	AD1
Number of Residues	13
Details	binding site for residue KR7 B 703

Chain	Residue
B	TYR325
B	MET439
B	ASN487
B	TYR495
B	TRP498
B	THR499
B	ILE502
B	GLN535
B	PHE538
B	PHE599
B	HOH805
B	HOH862
B	HOH870

site_id	AD2
Number of Residues	7
Details	binding site for residue SO4 B 704

Chain	Residue
B	HIS271
B	VAL272
B	PHE273
B	ARG274
B	GLN493
B	LEU494
B	GLN497

site_id	AD3
Number of Residues	6
Details	binding site for residue ZN C 701

Chain	Residue
C	HIS330
C	HIS366
C	ASP367
C	ASP484
C	HOH833
C	HOH867

site_id	AD4
Number of Residues	6
Details	binding site for residue MG C 702

Chain	Residue
C	ASP367
C	HOH828
C	HOH833
C	HOH849
C	HOH903
C	HOH912

site_id	AD5
Number of Residues	13
Details	binding site for residue KR7 C 703

Chain	Residue
C	TRP498
C	THR499
C	ILE502
C	GLN535
C	PHE538
C	PHE599
C	HOH843
C	HOH860
C	HOH902
C	TYR325
C	MET439
C	ASN487
C	TYR495

site_id	AD6
Number of Residues	8
Details	binding site for residue SO4 C 704

Chain	Residue
C	HIS271
C	VAL272
C	PHE273
C	ARG274
C	GLN493
C	LEU494
C	GLN497
C	HOH839

site_id	AD7
Number of Residues	6
Details	binding site for residue ZN D 701

Chain	Residue
D	HIS330
D	HIS366
D	ASP367
D	ASP484
D	HOH817
D	HOH870

site_id	AD8
Number of Residues	6
Details	binding site for residue MG D 702

Chain	Residue
D	ASP367
D	HOH804
D	HOH817
D	HOH856
D	HOH857
D	HOH895

site_id	AD9
Number of Residues	13
Details	binding site for residue KR7 D 703

Chain	Residue
D	TYR325
D	MET439
D	ASN487
D	TYR495
D	TRP498
D	THR499
D	ILE502
D	GLN535
D	PHE538
D	PHE599
D	HOH833
D	HOH855
D	HOH862

site_id	AE1
Number of Residues	7
Details	binding site for residue BTB D 704

Chain	Residue
B	HIS320
B	ASP322
B	HOH809
D	HIS318
D	GLU409
D	ZN705
D	HOH803

site_id	AE2
Number of Residues	2
Details	binding site for residue ZN D 705

Chain	Residue
D	HIS318
D	BTB704

site_id	AE3
Number of Residues	6
Details	binding site for residue SO4 D 706

Chain	Residue
D	HIS271
D	VAL272
D	PHE273
D	ARG274
D	LEU494
D	GLN497

Functional Information from PROSITE/UniProt

site_id	PS00126
Number of Residues	12
Details	PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF

Chain	Residue	Details
A	HIS366-PHE377

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"Q07343","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14609333","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15260978","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PTW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TB7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14609333","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15260978","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15576036","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17582435","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PTW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TB7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TBB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XON","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PW3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14609333","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15260978","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15576036","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17582435","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PTW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TB7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TBB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XON","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PW3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14609333","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PTW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)