6NF8

Structure of human mitochondrial translation initiation factor 3 bound to the small ribosomal subunit -Class I

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0003735	molecular_function	structural constituent of ribosome
a	0005739	cellular_component	mitochondrion
a	0005743	cellular_component	mitochondrial inner membrane
a	0005763	cellular_component	mitochondrial small ribosomal subunit
a	0005840	cellular_component	ribosome
a	0032543	biological_process	mitochondrial translation
a	1990904	cellular_component	ribonucleoprotein complex
b	0003735	molecular_function	structural constituent of ribosome
b	0005739	cellular_component	mitochondrion
b	0005743	cellular_component	mitochondrial inner membrane
b	0005763	cellular_component	mitochondrial small ribosomal subunit
b	0005840	cellular_component	ribosome
b	0006412	biological_process	translation
b	0032543	biological_process	mitochondrial translation
b	1990904	cellular_component	ribonucleoprotein complex
B	0003735	molecular_function	structural constituent of ribosome
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0005763	cellular_component	mitochondrial small ribosomal subunit
B	0005840	cellular_component	ribosome
B	0006412	biological_process	translation
B	0015935	cellular_component	small ribosomal subunit
B	0032543	biological_process	mitochondrial translation
B	0061668	biological_process	mitochondrial ribosome assembly
B	1990904	cellular_component	ribonucleoprotein complex
c	0003735	molecular_function	structural constituent of ribosome
c	0005739	cellular_component	mitochondrion
c	0005743	cellular_component	mitochondrial inner membrane
c	0005763	cellular_component	mitochondrial small ribosomal subunit
c	0005840	cellular_component	ribosome
c	0032543	biological_process	mitochondrial translation
c	1990904	cellular_component	ribonucleoprotein complex
C	0003735	molecular_function	structural constituent of ribosome
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005763	cellular_component	mitochondrial small ribosomal subunit
C	0005840	cellular_component	ribosome
C	0032543	biological_process	mitochondrial translation
C	1990904	cellular_component	ribonucleoprotein complex
d	0003735	molecular_function	structural constituent of ribosome
d	0005739	cellular_component	mitochondrion
d	0005743	cellular_component	mitochondrial inner membrane
d	0005763	cellular_component	mitochondrial small ribosomal subunit
d	0005840	cellular_component	ribosome
d	0032543	biological_process	mitochondrial translation
d	1990904	cellular_component	ribonucleoprotein complex
e	0000049	molecular_function	tRNA binding
e	0003723	molecular_function	RNA binding
e	0005737	cellular_component	cytoplasm
e	0005739	cellular_component	mitochondrion
e	0005743	cellular_component	mitochondrial inner membrane
e	0005763	cellular_component	mitochondrial small ribosomal subunit
e	0005840	cellular_component	ribosome
e	0006417	biological_process	regulation of translation
e	0008283	biological_process	cell population proliferation
e	0019843	molecular_function	rRNA binding
e	0032543	biological_process	mitochondrial translation
e	1990904	cellular_component	ribonucleoprotein complex
E	0003723	molecular_function	RNA binding
E	0003735	molecular_function	structural constituent of ribosome
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0005763	cellular_component	mitochondrial small ribosomal subunit
E	0005840	cellular_component	ribosome
E	0006412	biological_process	translation
E	0032543	biological_process	mitochondrial translation
E	1990904	cellular_component	ribonucleoprotein complex
f	0005739	cellular_component	mitochondrion
f	0005743	cellular_component	mitochondrial inner membrane
f	0005763	cellular_component	mitochondrial small ribosomal subunit
f	0005840	cellular_component	ribosome
f	0032543	biological_process	mitochondrial translation
f	1990904	cellular_component	ribonucleoprotein complex
F	0003735	molecular_function	structural constituent of ribosome
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005763	cellular_component	mitochondrial small ribosomal subunit
F	0005840	cellular_component	ribosome
F	0006412	biological_process	translation
F	0019843	molecular_function	rRNA binding
F	0032543	biological_process	mitochondrial translation
F	0070181	molecular_function	small ribosomal subunit rRNA binding
F	1990904	cellular_component	ribonucleoprotein complex
g	0005761	cellular_component	mitochondrial ribosome
g	0006915	biological_process	apoptotic process
g	0015935	cellular_component	small ribosomal subunit
G	0003729	molecular_function	mRNA binding
G	0003735	molecular_function	structural constituent of ribosome
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0005763	cellular_component	mitochondrial small ribosomal subunit
G	0005840	cellular_component	ribosome
G	0006412	biological_process	translation
G	0019843	molecular_function	rRNA binding
G	0032543	biological_process	mitochondrial translation
G	1990904	cellular_component	ribonucleoprotein complex
h	0003735	molecular_function	structural constituent of ribosome
h	0005739	cellular_component	mitochondrion
h	0005743	cellular_component	mitochondrial inner membrane
h	0005763	cellular_component	mitochondrial small ribosomal subunit
h	0005840	cellular_component	ribosome
h	0019904	molecular_function	protein domain specific binding
h	1990904	cellular_component	ribonucleoprotein complex
i	0005739	cellular_component	mitochondrion
i	0005743	cellular_component	mitochondrial inner membrane
i	0005763	cellular_component	mitochondrial small ribosomal subunit
i	0005840	cellular_component	ribosome
i	1990904	cellular_component	ribonucleoprotein complex
I	0003723	molecular_function	RNA binding
I	0003735	molecular_function	structural constituent of ribosome
I	0005739	cellular_component	mitochondrion
I	0005743	cellular_component	mitochondrial inner membrane
I	0005763	cellular_component	mitochondrial small ribosomal subunit
I	0005840	cellular_component	ribosome
I	0006412	biological_process	translation
I	0070013	cellular_component	intracellular organelle lumen
I	1990904	cellular_component	ribonucleoprotein complex
j	0003735	molecular_function	structural constituent of ribosome
j	0005739	cellular_component	mitochondrion
j	0005743	cellular_component	mitochondrial inner membrane
j	0005763	cellular_component	mitochondrial small ribosomal subunit
j	0005840	cellular_component	ribosome
j	0032543	biological_process	mitochondrial translation
j	1990904	cellular_component	ribonucleoprotein complex
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0005763	cellular_component	mitochondrial small ribosomal subunit
J	0005840	cellular_component	ribosome
J	1990904	cellular_component	ribonucleoprotein complex
k	0003735	molecular_function	structural constituent of ribosome
k	0005739	cellular_component	mitochondrion
k	0005743	cellular_component	mitochondrial inner membrane
k	0005763	cellular_component	mitochondrial small ribosomal subunit
k	0005840	cellular_component	ribosome
k	0032543	biological_process	mitochondrial translation
k	1990904	cellular_component	ribonucleoprotein complex
K	0003735	molecular_function	structural constituent of ribosome
K	0005739	cellular_component	mitochondrion
K	0005743	cellular_component	mitochondrial inner membrane
K	0005763	cellular_component	mitochondrial small ribosomal subunit
K	0005840	cellular_component	ribosome
K	0006412	biological_process	translation
K	0032543	biological_process	mitochondrial translation
K	0043043	biological_process	peptide biosynthetic process
K	1990904	cellular_component	ribonucleoprotein complex
L	0003735	molecular_function	structural constituent of ribosome
L	0005739	cellular_component	mitochondrion
L	0005743	cellular_component	mitochondrial inner membrane
L	0005763	cellular_component	mitochondrial small ribosomal subunit
L	0005840	cellular_component	ribosome
L	0006412	biological_process	translation
L	0015935	cellular_component	small ribosomal subunit
L	0032543	biological_process	mitochondrial translation
L	1990904	cellular_component	ribonucleoprotein complex
m	0001650	cellular_component	fibrillar center
m	0005654	cellular_component	nucleoplasm
m	0005739	cellular_component	mitochondrion
m	0005761	cellular_component	mitochondrial ribosome
m	0032543	biological_process	mitochondrial translation
n	0005739	cellular_component	mitochondrion
n	0016301	molecular_function	kinase activity
N	0003735	molecular_function	structural constituent of ribosome
N	0005737	cellular_component	cytoplasm
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0005763	cellular_component	mitochondrial small ribosomal subunit
N	0005840	cellular_component	ribosome
N	0006412	biological_process	translation
N	0032543	biological_process	mitochondrial translation
N	1990904	cellular_component	ribonucleoprotein complex
o	0005739	cellular_component	mitochondrion
o	0019843	molecular_function	rRNA binding
o	0032543	biological_process	mitochondrial translation
o	0043024	molecular_function	ribosomal small subunit binding
O	0003735	molecular_function	structural constituent of ribosome
O	0005743	cellular_component	mitochondrial inner membrane
O	0005759	cellular_component	mitochondrial matrix
O	0005761	cellular_component	mitochondrial ribosome
O	0005763	cellular_component	mitochondrial small ribosomal subunit
O	0005840	cellular_component	ribosome
O	0006412	biological_process	translation
O	0032543	biological_process	mitochondrial translation
O	1990904	cellular_component	ribonucleoprotein complex
p	0003735	molecular_function	structural constituent of ribosome
p	0005739	cellular_component	mitochondrion
p	0005743	cellular_component	mitochondrial inner membrane
p	0005763	cellular_component	mitochondrial small ribosomal subunit
p	0005840	cellular_component	ribosome
p	0006412	biological_process	translation
p	0032543	biological_process	mitochondrial translation
p	1990904	cellular_component	ribonucleoprotein complex
P	0003735	molecular_function	structural constituent of ribosome
P	0005739	cellular_component	mitochondrion
P	0005743	cellular_component	mitochondrial inner membrane
P	0005763	cellular_component	mitochondrial small ribosomal subunit
P	0005840	cellular_component	ribosome
P	0006412	biological_process	translation
P	0032543	biological_process	mitochondrial translation
P	1990904	cellular_component	ribonucleoprotein complex
Q	0003723	molecular_function	RNA binding
Q	0003735	molecular_function	structural constituent of ribosome
Q	0005739	cellular_component	mitochondrion
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0005763	cellular_component	mitochondrial small ribosomal subunit
Q	0005840	cellular_component	ribosome
Q	0006412	biological_process	translation
Q	0019843	molecular_function	rRNA binding
Q	1990904	cellular_component	ribonucleoprotein complex
R	0003735	molecular_function	structural constituent of ribosome
R	0005739	cellular_component	mitochondrion
R	0005743	cellular_component	mitochondrial inner membrane
R	0005763	cellular_component	mitochondrial small ribosomal subunit
R	0005840	cellular_component	ribosome
R	0006412	biological_process	translation
R	0070181	molecular_function	small ribosomal subunit rRNA binding
R	1990904	cellular_component	ribonucleoprotein complex
U	0003735	molecular_function	structural constituent of ribosome
U	0005739	cellular_component	mitochondrion
U	0005743	cellular_component	mitochondrial inner membrane
U	0005763	cellular_component	mitochondrial small ribosomal subunit
U	0005840	cellular_component	ribosome
U	0006412	biological_process	translation
U	0032543	biological_process	mitochondrial translation
U	1990904	cellular_component	ribonucleoprotein complex
z	0003743	molecular_function	translation initiation factor activity
z	0006413	biological_process	translational initiation

Functional Information from PROSITE/UniProt

site_id	PS00054
Number of Residues	23
Details	RIBOSOMAL_S11 Ribosomal protein S11 signature. IkGLtmG.GLeVisitDnTPiPHN

Chain	Residue	Details
K	ILE165-ASN187

---

site_id	PS00055
Number of Residues	8
Details	RIBOSOMAL_S12 Ribosomal protein S12 signature. KkPNSAnR

Chain	Residue	Details
L	LYS71-ARG78

---

site_id	PS00057
Number of Residues	25
Details	RIBOSOMAL_S18 Ribosomal protein S18 signature. VDYkn.VqlLsqFISPftGCIygrHI

Chain	Residue	Details
R	VAL73-ILE97

---

site_id	PS00360
Number of Residues	19
Details	RIBOSOMAL_S9 Ribosomal protein S9 signature. GGGrsSQagAirlAmSRAL

Chain	Residue	Details
I	GLY334-LEU352

---

site_id	PS00585
Number of Residues	33
Details	RIBOSOMAL_S5 Ribosomal protein S5 signature. GRkrsVrVlvAVGNgr.GaAGfAigkat.ERad.AF

Chain	Residue	Details
E	GLY236-PHE268

---

site_id	PS00962
Number of Residues	12
Details	RIBOSOMAL_S2_1 Ribosomal protein S2 signature 1. VrSLFNARVHLG

Chain	Residue	Details
B	VAL70-GLY81

---

site_id	PS01037
Number of Residues	18
Details	SBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PITpEelALIYNlrkMvK

Chain	Residue	Details
g	PRO280-LYS297

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	64
Details	Domain: {"description":"S5 DRBM","evidences":[{"source":"PROSITE-ProRule","id":"PRU00268","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	67
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	34
Details	Repeat: {"description":"PPR 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	35
Details	Repeat: {"description":"PPR 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9Y2R9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	9
Details	Compositional bias: {"description":"Basic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"Q9Y3D9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q8VE22","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9Y3D9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9Y2Q9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---