6NEX

Fab fragment of anti-cocaine antibody h2E2

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue CL L 301

Chain	Residue
L	ASP85
L	TYR143
L	MLY169
L	TYR175

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site_id	AC2
Number of Residues	2
Details	binding site for residue CL L 302

Chain	Residue
H	LYS214
L	SER125

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site_id	AC3
Number of Residues	4
Details	binding site for residue FMT L 303

Chain	Residue
L	ASN33
L	SER24
L	THR26
L	THR28

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site_id	AC4
Number of Residues	2
Details	binding site for residue FMT L 304

Chain	Residue
L	GLN39
L	ASP84

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site_id	AC5
Number of Residues	2
Details	binding site for residue FMT L 305

Chain	Residue
L	THR76
L	THR78

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site_id	AC6
Number of Residues	7
Details	binding site for residue ACT H 301

Chain	Residue
H	ASN35
H	VAL37
H	MLY98
H	GLU99
L	ASN36
L	TYR98
L	PHE100

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site_id	AC7
Number of Residues	2
Details	binding site for residue FMT A 302

Chain	Residue
A	ASN36
A	TYR98

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site_id	AC8
Number of Residues	10
Details	binding site for Ligand residues MLY A 174 through TYR A 175 bound to ASN A 173

Chain	Residue
A	SER140
A	ASP141
A	PHE142
A	GLY145
A	SER168
A	LYS169
A	GLN170
A	ASN172
A	ASN173
A	ALA176

---

site_id	AC9
Number of Residues	10
Details	binding site for Ligand residues MLY L 105 through VAL L 106 bound to THR L 104

Chain	Residue
L	SER8
L	ALA9
L	LEU10
L	ASP85
L	ALA86
L	TYR88
L	THR104
L	THR107
L	TYR175
L	HOH414

---

site_id	AD1
Number of Residues	14
Details	binding site for Ligand residues MLY L 169 through GLN L 170 bound to SER L 168

Chain	Residue
H	HIS164
L	ASN43
L	ASP85
L	SER140
L	ASP141
L	SER168
L	SER171
L	ASN172
L	ASN173
L	MLY174
L	TYR175
L	ALA176
L	CL301
L	HOH433

---

site_id	AD2
Number of Residues	12
Details	binding site for Ligand residues MLY L 174 through TYR L 175 bound to ASN L 173

Chain	Residue
L	MLY105
L	SER140
L	ASP141
L	PHE142
L	GLY145
L	SER168
L	MLY169
L	GLN170
L	ASN172
L	ASN173
L	ALA176
L	CL301

---

site_id	AD3
Number of Residues	10
Details	binding site for residues MLY A 40 and MLY A 41

Chain	Residue
A	GLN39
A	PRO42
A	ASN43
A	HIS44
A	VAL45
A	PHE46
A	GLU83
A	ALA86
A	MET87
B	GLN39

---

site_id	AD4
Number of Residues	8
Details	binding site for residues MLY L 40 and MLY L 41

Chain	Residue
L	GLN39
L	PRO42
L	ASN43
L	HIS44
L	PHE46
L	GLU83
L	ALA86
L	MET87

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Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
B	TYR194-HIS200
H	TYR194-HIS200
A	TYR194-HIS200
L	TYR194-HIS200

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