6NE6

Crystal Structure of heterotrimeric G-protein alpha subunit Galpha7 from Naegleria fowleri

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001664	molecular_function	G protein-coupled receptor binding
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005834	cellular_component	heterotrimeric G-protein complex
A	0007165	biological_process	signal transduction
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007188	biological_process	adenylate cyclase-modulating G protein-coupled receptor signaling pathway
A	0019001	molecular_function	guanyl nucleotide binding
A	0031683	molecular_function	G-protein beta/gamma-subunit complex binding
A	0032502	biological_process	developmental process
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue NA A 401

Chain	Residue
A	HIS29
A	HIS31
A	HOH716
A	HOH730
A	HOH743
A	HOH782

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site_id	AC2
Number of Residues	6
Details	binding site for residue NA A 402

Chain	Residue
A	HOH541
A	HOH560
A	HOH695
A	HIS28
A	HIS30
A	HIS217

---

site_id	AC3
Number of Residues	6
Details	binding site for residue EDO A 403

Chain	Residue
A	ASP43
A	GLN150
A	ILE151
A	GLU152
A	ARG245
A	HOH519

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site_id	AC4
Number of Residues	4
Details	binding site for residue EDO A 404

Chain	Residue
A	ILE95
A	SER96
A	THR97
A	GLU98

---

site_id	AC5
Number of Residues	6
Details	binding site for residue EDO A 405

Chain	Residue
A	GLU75
A	ASP119
A	LYS120
A	VAL121
A	TRP122
A	HOH504

---

site_id	AC6
Number of Residues	8
Details	binding site for residue EDO A 406

Chain	Residue
A	ALA127
A	GLN128
A	LEU162
A	ASP163
A	GLY166
A	HOH631
A	HOH694
A	HOH720

---

site_id	AC7
Number of Residues	5
Details	binding site for residue EDO A 407

Chain	Residue
A	HIS29
A	HIS30
A	ASP241
A	SER242
A	HOH695

---

site_id	AC8
Number of Residues	5
Details	binding site for residue EDO A 408

Chain	Residue
A	ASN58
A	ASN59
A	GLY60
A	GLN141
A	HOH517

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site_id	AC9
Number of Residues	5
Details	binding site for residue EDO A 409

Chain	Residue
A	LYS89
A	ARG101
A	ALA104
A	GLU105
A	GLU108

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