6NDL

Crystal structure of Staphylococcus aureus biotin protein ligase in complex with a sulfonamide inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004077	molecular_function	biotin-[acetyl-CoA-carboxylase] ligase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006355	biological_process	regulation of DNA-templated transcription
A	0016740	molecular_function	transferase activity
A	0016874	molecular_function	ligase activity
A	0036211	biological_process	protein modification process

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue GOL A 401

Chain	Residue
A	ASP235
A	ASN237
A	HOH552

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site_id	AC2
Number of Residues	5
Details	binding site for residue GOL A 402

Chain	Residue
A	LYS16
A	ASP240
A	GLN243
A	GLU246
A	HOH508

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site_id	AC3
Number of Residues	5
Details	binding site for residue GOL A 403

Chain	Residue
A	ASN30
A	ILE31
A	HOH514
A	HOH528
A	GLU27

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site_id	AC4
Number of Residues	6
Details	binding site for residue GOL A 404

Chain	Residue
A	LYS37
A	ILE40
A	ASP41
A	LYS44
A	SER52
A	HIS58

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site_id	AC5
Number of Residues	5
Details	binding site for residue GOL A 405

Chain	Residue
A	ILE272
A	TRP278
A	ASN279
A	HOH503
A	HOH593

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site_id	AC6
Number of Residues	25
Details	binding site for residue BQX A 406

Chain	Residue
A	SER93
A	THR94
A	GLN95
A	GLN116
A	GLY119
A	ARG120
A	GLY121
A	ARG122
A	ARG125
A	HIS126
A	TRP127
A	SER128
A	MET137
A	SER138
A	ASN179
A	ASP180
A	LYS187
A	GLY190
A	PHE191
A	ILE209
A	GLY210
A	ASN212
A	ILE224
A	HOH583
A	HOH662

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