6NDL
Crystal structure of Staphylococcus aureus biotin protein ligase in complex with a sulfonamide inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0004077 | molecular_function | biotin--[biotin carboxyl-carrier protein] ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0009249 | biological_process | protein lipoylation |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016874 | molecular_function | ligase activity |
| A | 0036211 | biological_process | protein modification process |
| A | 0140096 | molecular_function | catalytic activity, acting on a protein |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 401 |
| Chain | Residue |
| A | ASP235 |
| A | ASN237 |
| A | HOH552 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 402 |
| Chain | Residue |
| A | LYS16 |
| A | ASP240 |
| A | GLN243 |
| A | GLU246 |
| A | HOH508 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 403 |
| Chain | Residue |
| A | ASN30 |
| A | ILE31 |
| A | HOH514 |
| A | HOH528 |
| A | GLU27 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 404 |
| Chain | Residue |
| A | LYS37 |
| A | ILE40 |
| A | ASP41 |
| A | LYS44 |
| A | SER52 |
| A | HIS58 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 405 |
| Chain | Residue |
| A | ILE272 |
| A | TRP278 |
| A | ASN279 |
| A | HOH503 |
| A | HOH593 |
| site_id | AC6 |
| Number of Residues | 25 |
| Details | binding site for residue BQX A 406 |
| Chain | Residue |
| A | SER93 |
| A | THR94 |
| A | GLN95 |
| A | GLN116 |
| A | GLY119 |
| A | ARG120 |
| A | GLY121 |
| A | ARG122 |
| A | ARG125 |
| A | HIS126 |
| A | TRP127 |
| A | SER128 |
| A | MET137 |
| A | SER138 |
| A | ASN179 |
| A | ASP180 |
| A | LYS187 |
| A | GLY190 |
| A | PHE191 |
| A | ILE209 |
| A | GLY210 |
| A | ASN212 |
| A | ILE224 |
| A | HOH583 |
| A | HOH662 |
