Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6NDD

RHODOCETIN IN COMPLEX WITH THE INTEGRIN ALPHA2-A DOMAIN WITH MANGANESE BOUND

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0008284	biological_process	positive regulation of cell population proliferation
A	0035821	biological_process	modulation of process of another organism
A	0038023	molecular_function	signaling receptor activity
A	0042834	molecular_function	peptidoglycan binding
A	0043434	biological_process	response to peptide hormone
A	0044278	biological_process	disruption of cell wall in another organism
A	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
A	0062023	cellular_component	collagen-containing extracellular matrix
A	0070492	molecular_function	oligosaccharide binding
A	0090729	molecular_function	toxin activity
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0008284	biological_process	positive regulation of cell population proliferation
B	0035821	biological_process	modulation of process of another organism
B	0038023	molecular_function	signaling receptor activity
B	0042834	molecular_function	peptidoglycan binding
B	0043434	biological_process	response to peptide hormone
B	0044278	biological_process	disruption of cell wall in another organism
B	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
B	0062023	cellular_component	collagen-containing extracellular matrix
B	0070492	molecular_function	oligosaccharide binding
B	0090729	molecular_function	toxin activity
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0008284	biological_process	positive regulation of cell population proliferation
D	0035821	biological_process	modulation of process of another organism
D	0038023	molecular_function	signaling receptor activity
D	0042834	molecular_function	peptidoglycan binding
D	0043434	biological_process	response to peptide hormone
D	0044278	biological_process	disruption of cell wall in another organism
D	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
D	0062023	cellular_component	collagen-containing extracellular matrix
D	0070492	molecular_function	oligosaccharide binding
D	0090729	molecular_function	toxin activity
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0008284	biological_process	positive regulation of cell population proliferation
E	0035821	biological_process	modulation of process of another organism
E	0038023	molecular_function	signaling receptor activity
E	0042834	molecular_function	peptidoglycan binding
E	0043434	biological_process	response to peptide hormone
E	0044278	biological_process	disruption of cell wall in another organism
E	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
E	0062023	cellular_component	collagen-containing extracellular matrix
E	0070492	molecular_function	oligosaccharide binding
E	0090729	molecular_function	toxin activity
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0008284	biological_process	positive regulation of cell population proliferation
G	0035821	biological_process	modulation of process of another organism
G	0038023	molecular_function	signaling receptor activity
G	0042834	molecular_function	peptidoglycan binding
G	0043434	biological_process	response to peptide hormone
G	0044278	biological_process	disruption of cell wall in another organism
G	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
G	0062023	cellular_component	collagen-containing extracellular matrix
G	0070492	molecular_function	oligosaccharide binding
G	0090729	molecular_function	toxin activity
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0008284	biological_process	positive regulation of cell population proliferation
H	0035821	biological_process	modulation of process of another organism
H	0038023	molecular_function	signaling receptor activity
H	0042834	molecular_function	peptidoglycan binding
H	0043434	biological_process	response to peptide hormone
H	0044278	biological_process	disruption of cell wall in another organism
H	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
H	0062023	cellular_component	collagen-containing extracellular matrix
H	0070492	molecular_function	oligosaccharide binding
H	0090729	molecular_function	toxin activity
J	0005576	cellular_component	extracellular region
J	0005615	cellular_component	extracellular space
J	0008284	biological_process	positive regulation of cell population proliferation
J	0035821	biological_process	modulation of process of another organism
J	0038023	molecular_function	signaling receptor activity
J	0042834	molecular_function	peptidoglycan binding
J	0043434	biological_process	response to peptide hormone
J	0044278	biological_process	disruption of cell wall in another organism
J	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
J	0062023	cellular_component	collagen-containing extracellular matrix
J	0070492	molecular_function	oligosaccharide binding
J	0090729	molecular_function	toxin activity
K	0005576	cellular_component	extracellular region
K	0005615	cellular_component	extracellular space
K	0008284	biological_process	positive regulation of cell population proliferation
K	0035821	biological_process	modulation of process of another organism
K	0038023	molecular_function	signaling receptor activity
K	0042834	molecular_function	peptidoglycan binding
K	0043434	biological_process	response to peptide hormone
K	0044278	biological_process	disruption of cell wall in another organism
K	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
K	0062023	cellular_component	collagen-containing extracellular matrix
K	0070492	molecular_function	oligosaccharide binding
K	0090729	molecular_function	toxin activity
M	0005576	cellular_component	extracellular region
M	0005615	cellular_component	extracellular space
M	0008284	biological_process	positive regulation of cell population proliferation
M	0035821	biological_process	modulation of process of another organism
M	0038023	molecular_function	signaling receptor activity
M	0042834	molecular_function	peptidoglycan binding
M	0043434	biological_process	response to peptide hormone
M	0044278	biological_process	disruption of cell wall in another organism
M	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
M	0062023	cellular_component	collagen-containing extracellular matrix
M	0070492	molecular_function	oligosaccharide binding
M	0090729	molecular_function	toxin activity
N	0005576	cellular_component	extracellular region
N	0005615	cellular_component	extracellular space
N	0008284	biological_process	positive regulation of cell population proliferation
N	0035821	biological_process	modulation of process of another organism
N	0038023	molecular_function	signaling receptor activity
N	0042834	molecular_function	peptidoglycan binding
N	0043434	biological_process	response to peptide hormone
N	0044278	biological_process	disruption of cell wall in another organism
N	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
N	0062023	cellular_component	collagen-containing extracellular matrix
N	0070492	molecular_function	oligosaccharide binding
N	0090729	molecular_function	toxin activity
P	0005576	cellular_component	extracellular region
P	0005615	cellular_component	extracellular space
P	0008284	biological_process	positive regulation of cell population proliferation
P	0035821	biological_process	modulation of process of another organism
P	0038023	molecular_function	signaling receptor activity
P	0042834	molecular_function	peptidoglycan binding
P	0043434	biological_process	response to peptide hormone
P	0044278	biological_process	disruption of cell wall in another organism
P	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
P	0062023	cellular_component	collagen-containing extracellular matrix
P	0070492	molecular_function	oligosaccharide binding
P	0090729	molecular_function	toxin activity
Q	0005576	cellular_component	extracellular region
Q	0005615	cellular_component	extracellular space
Q	0008284	biological_process	positive regulation of cell population proliferation
Q	0035821	biological_process	modulation of process of another organism
Q	0038023	molecular_function	signaling receptor activity
Q	0042834	molecular_function	peptidoglycan binding
Q	0043434	biological_process	response to peptide hormone
Q	0044278	biological_process	disruption of cell wall in another organism
Q	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
Q	0062023	cellular_component	collagen-containing extracellular matrix
Q	0070492	molecular_function	oligosaccharide binding
Q	0090729	molecular_function	toxin activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue SO4 A 201

Chain	Residue
A	PHE19
A	ASN20
A	GLU21

site_id	AC2
Number of Residues	2
Details	binding site for residue SO4 A 202

Chain	Residue
A	ARG73
A	ARG75

site_id	AC3
Number of Residues	6
Details	binding site for residue MN C 401

Chain	Residue
C	SO4402
C	NA403
C	ASP180
C	SER182
C	SER184
C	ASP283

site_id	AC4
Number of Residues	7
Details	binding site for residue SO4 C 402

Chain	Residue
B	ARG92
B	LYS114
C	SER184
C	ASP248
C	THR250
C	MN401
C	NA403

site_id	AC5
Number of Residues	4
Details	binding site for residue NA C 403

Chain	Residue
C	SER182
C	SER184
C	MN401
C	SO4402

site_id	AC6
Number of Residues	2
Details	binding site for residue CL C 404

Chain	Residue
C	ARG339
O	ARG339

site_id	AC7
Number of Residues	4
Details	binding site for residue SO4 D 201

Chain	Residue
D	PHE19
D	ASN20
D	GLU21
D	NH4202

site_id	AC8
Number of Residues	3
Details	binding site for residue NH4 D 202

Chain	Residue
D	GLN17
D	ALA18
D	SO4201

site_id	AC9
Number of Residues	2
Details	binding site for residue SO4 E 201

Chain	Residue
E	LYS101
E	ARG104

site_id	AD1
Number of Residues	1
Details	binding site for residue CL E 202

Chain	Residue
E	LYS59

site_id	AD2
Number of Residues	6
Details	binding site for residue MN F 401

Chain	Residue
F	ASP180
F	SER182
F	SER184
F	ASP283
F	SO4402
F	NA403

site_id	AD3
Number of Residues	6
Details	binding site for residue SO4 F 402

Chain	Residue
E	ARG110
E	LYS114
F	SER184
F	THR250
F	MN401
F	NA403

site_id	AD4
Number of Residues	4
Details	binding site for residue NA F 403

Chain	Residue
F	SER182
F	SER184
F	MN401
F	SO4402

site_id	AD5
Number of Residues	2
Details	binding site for residue CL G 201

Chain	Residue
C	ARG260
G	GLY7

site_id	AD6
Number of Residues	3
Details	binding site for residue SO4 G 202

Chain	Residue
G	PHE19
G	ASN20
G	GLU21

site_id	AD7
Number of Residues	1
Details	binding site for residue CL H 201

Chain	Residue
H	LYS59

site_id	AD8
Number of Residues	6
Details	binding site for residue MN I 401

Chain	Residue
I	ASP180
I	SER182
I	SER184
I	ASP283
I	SO4402
I	NA403

site_id	AD9
Number of Residues	7
Details	binding site for residue SO4 I 402

Chain	Residue
H	ARG110
H	LYS114
I	SER184
I	THR250
I	TYR314
I	MN401
I	NA403

site_id	AE1
Number of Residues	4
Details	binding site for residue NA I 403

Chain	Residue
I	SER182
I	SER184
I	MN401
I	SO4402

site_id	AE2
Number of Residues	3
Details	binding site for residue SO4 J 201

Chain	Residue
J	PHE19
J	ASN20
J	GLU21

site_id	AE3
Number of Residues	1
Details	binding site for residue CL J 202

Chain	Residue
J	ARG73

site_id	AE4
Number of Residues	1
Details	binding site for residue CL K 201

Chain	Residue
K	ARG14

site_id	AE5
Number of Residues	6
Details	binding site for residue SO4 K 202

Chain	Residue
K	ARG92
K	LYS114
L	ASP248
L	THR250
L	MN401
L	NA402

site_id	AE6
Number of Residues	6
Details	binding site for residue MN L 401

Chain	Residue
K	SO4202
L	ASP180
L	SER182
L	SER184
L	ASP283
L	NA402

site_id	AE7
Number of Residues	4
Details	binding site for residue NA L 402

Chain	Residue
K	SO4202
L	SER182
L	SER184
L	MN401

site_id	AE8
Number of Residues	1
Details	binding site for residue CL L 403

Chain	Residue
L	ARG260

site_id	AE9
Number of Residues	2
Details	binding site for residue CL M 201

Chain	Residue
M	GLN102
N	ARG91

site_id	AF1
Number of Residues	6
Details	binding site for residue SO4 N 201

Chain	Residue
O	ASP248
O	THR250
O	MN401
O	NA402
N	LYS114
O	SER184

site_id	AF2
Number of Residues	7
Details	binding site for residue MN O 401

Chain	Residue
N	SO4201
O	ASP180
O	SER182
O	SER184
O	THR250
O	ASP283
O	NA402

site_id	AF3
Number of Residues	4
Details	binding site for residue NA O 402

Chain	Residue
N	SO4201
O	SER182
O	SER184
O	MN401

site_id	AF4
Number of Residues	3
Details	binding site for residue SO4 O 403

Chain	Residue
O	ARG260
O	LYS261
O	GLN298

site_id	AF5
Number of Residues	2
Details	binding site for residue SO4 Q 201

Chain	Residue
Q	TYR8
Q	ASN9

site_id	AF6
Number of Residues	5
Details	binding site for residue SO4 Q 202

Chain	Residue
Q	LYS114
R	ASP248
R	THR250
R	MN401
R	NA404

site_id	AF7
Number of Residues	7
Details	binding site for residue MN R 401

Chain	Residue
Q	SO4202
R	ASP180
R	SER182
R	SER184
R	THR250
R	ASP283
R	NA404

site_id	AF8
Number of Residues	3
Details	binding site for residue SO4 R 402

Chain	Residue
R	ARG260
R	LYS261
R	GLN298

site_id	AF9
Number of Residues	1
Details	binding site for residue CL R 403

Chain	Residue
R	ARG339

site_id	AG1
Number of Residues	4
Details	binding site for residue NA R 404

Chain	Residue
Q	SO4202
R	SER182
R	SER184
R	MN401

Functional Information from PROSITE/UniProt

site_id	PS00615
Number of Residues	26
Details	C_TYPE_LECTIN_1 C-type lectin domain signature. CAvmvvktdrif..WFNRGCektvs.FVC

Chain	Residue	Details
B	CYS95-CYS120

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:16263699, ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:19349973

Chain	Residue	Details
C	ASN343
F	ASN343
I	ASN343
L	ASN343
O	ASN343
R	ASN343

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)