6NBE
Ternary Complex of Ac-Alpha-Actin with Profilin and CoA-NAA80
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0001725 | cellular_component | stress fiber |
| A | 0003785 | molecular_function | actin monomer binding |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005523 | molecular_function | tropomyosin binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005865 | cellular_component | striated muscle thin filament |
| A | 0005884 | cellular_component | actin filament |
| A | 0010628 | biological_process | positive regulation of gene expression |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019904 | molecular_function | protein domain specific binding |
| A | 0030027 | cellular_component | lamellipodium |
| A | 0030041 | biological_process | actin filament polymerization |
| A | 0030175 | cellular_component | filopodium |
| A | 0030240 | biological_process | skeletal muscle thin filament assembly |
| A | 0031013 | molecular_function | troponin I binding |
| A | 0031432 | molecular_function | titin binding |
| A | 0031941 | cellular_component | filamentous actin |
| A | 0032036 | molecular_function | myosin heavy chain binding |
| A | 0032432 | cellular_component | actin filament bundle |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0044297 | cellular_component | cell body |
| A | 0048306 | molecular_function | calcium-dependent protein binding |
| A | 0048741 | biological_process | skeletal muscle fiber development |
| A | 0051017 | biological_process | actin filament bundle assembly |
| A | 0090131 | biological_process | mesenchyme migration |
| A | 0098723 | cellular_component | skeletal muscle myofibril |
| A | 0140660 | molecular_function | cytoskeletal motor activator activity |
| N | 0008080 | molecular_function | N-acetyltransferase activity |
| N | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| P | 0000774 | molecular_function | adenyl-nucleotide exchange factor activity |
| P | 0001784 | molecular_function | phosphotyrosine residue binding |
| P | 0001843 | biological_process | neural tube closure |
| P | 0003723 | molecular_function | RNA binding |
| P | 0003779 | molecular_function | actin binding |
| P | 0003785 | molecular_function | actin monomer binding |
| P | 0005515 | molecular_function | protein binding |
| P | 0005546 | molecular_function | phosphatidylinositol-4,5-bisphosphate binding |
| P | 0005634 | cellular_component | nucleus |
| P | 0005737 | cellular_component | cytoplasm |
| P | 0005829 | cellular_component | cytosol |
| P | 0005856 | cellular_component | cytoskeleton |
| P | 0005925 | cellular_component | focal adhesion |
| P | 0005938 | cellular_component | cell cortex |
| P | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| P | 0010634 | biological_process | positive regulation of epithelial cell migration |
| P | 0016020 | cellular_component | membrane |
| P | 0030036 | biological_process | actin cytoskeleton organization |
| P | 0030833 | biological_process | regulation of actin filament polymerization |
| P | 0030837 | biological_process | negative regulation of actin filament polymerization |
| P | 0030838 | biological_process | positive regulation of actin filament polymerization |
| P | 0031267 | molecular_function | small GTPase binding |
| P | 0032232 | biological_process | negative regulation of actin filament bundle assembly |
| P | 0032233 | biological_process | positive regulation of actin filament bundle assembly |
| P | 0032781 | biological_process | positive regulation of ATP-dependent activity |
| P | 0044087 | biological_process | regulation of cellular component biogenesis |
| P | 0045296 | molecular_function | cadherin binding |
| P | 0050804 | biological_process | modulation of chemical synaptic transmission |
| P | 0050821 | biological_process | protein stabilization |
| P | 0051497 | biological_process | negative regulation of stress fiber assembly |
| P | 0060074 | biological_process | synapse maturation |
| P | 0070062 | cellular_component | extracellular exosome |
| P | 0070064 | molecular_function | proline-rich region binding |
| P | 0072562 | cellular_component | blood microparticle |
| P | 0098885 | biological_process | modification of postsynaptic actin cytoskeleton |
| P | 0098978 | cellular_component | glutamatergic synapse |
| P | 0110053 | biological_process | regulation of actin filament organization |
| P | 1900029 | biological_process | positive regulation of ruffle assembly |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 400 |
| Chain | Residue |
| A | ATP401 |
| A | HOH520 |
| A | HOH524 |
| A | HOH543 |
| A | HOH544 |
| A | HOH564 |
| site_id | AC2 |
| Number of Residues | 27 |
| Details | binding site for residue ATP A 401 |
| Chain | Residue |
| A | LEU16 |
| A | LYS18 |
| A | GLY156 |
| A | ASP157 |
| A | GLY158 |
| A | VAL159 |
| A | GLY182 |
| A | ARG210 |
| A | LYS213 |
| A | GLU214 |
| A | GLY301 |
| A | GLY302 |
| A | THR303 |
| A | MET305 |
| A | TYR306 |
| A | LYS336 |
| A | CA400 |
| A | HOH522 |
| A | HOH543 |
| A | HOH562 |
| A | HOH564 |
| A | HOH584 |
| A | HOH623 |
| A | HOH628 |
| A | GLY13 |
| A | SER14 |
| A | GLY15 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | binding site for residue LAB A 402 |
| Chain | Residue |
| A | GLY15 |
| A | LEU16 |
| A | PRO32 |
| A | ILE34 |
| A | GLN59 |
| A | TYR69 |
| A | ASP157 |
| A | ARG183 |
| A | THR186 |
| A | ARG206 |
| A | GLU207 |
| A | ARG210 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 403 |
| Chain | Residue |
| A | HIC73 |
| A | ARG183 |
| A | ASP184 |
| A | HOH503 |
| A | HOH508 |
| N | THR206 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 404 |
| Chain | Residue |
| A | TYR198 |
| A | SER199 |
| A | PHE200 |
| A | GLU205 |
| A | HOH506 |
| site_id | AC6 |
| Number of Residues | 31 |
| Details | binding site for residue COA N 400 |
| Chain | Residue |
| A | KKD1 |
| A | ILE267 |
| A | GLY268 |
| N | ALA74 |
| N | HIS76 |
| N | GLN104 |
| N | TRP105 |
| N | VAL163 |
| N | VAL164 |
| N | VAL165 |
| N | ARG170 |
| N | GLY171 |
| N | ARG172 |
| N | GLY173 |
| N | PHE174 |
| N | GLY175 |
| N | ARG176 |
| N | THR198 |
| N | GLN201 |
| N | PHE204 |
| N | TYR205 |
| N | HIS207 |
| N | HOH507 |
| N | HOH511 |
| N | HOH513 |
| N | HOH515 |
| N | HOH548 |
| N | HOH549 |
| N | HOH573 |
| N | HOH577 |
| N | HOH583 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | binding site for residue MES N 401 |
| Chain | Residue |
| A | SER234 |
| A | GLU237 |
| A | LYS238 |
| A | SER239 |
| N | PHE123 |
| N | PRO155 |
| N | GLN156 |
| N | ARG189 |
| N | GLY190 |
| N | PHE191 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue GOL N 402 |
| Chain | Residue |
| N | ALA166 |
| N | ARG167 |
| N | HOH537 |
| N | HOH552 |
| N | HOH562 |
| N | LEU100 |
| N | ASP103 |
Functional Information from PROSITE/UniProt
| site_id | PS00406 |
| Number of Residues | 11 |
| Details | ACTINS_1 Actins signature 1. YVGDEAQs.KRG |
| Chain | Residue | Details |
| A | TYR53-GLY63 |
| site_id | PS00414 |
| Number of Residues | 9 |
| Details | PROFILIN Profilin signature. mAgWNaYiD |
| Chain | Residue | Details |
| P | MET0-ASP8 |
| site_id | PS00432 |
| Number of Residues | 9 |
| Details | ACTINS_2 Actins signature 2. WITKqEYDE |
| Chain | Residue | Details |
| A | TRP356-GLU364 |
| site_id | PS01132 |
| Number of Residues | 13 |
| Details | ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR |
| Chain | Residue | Details |
| A | LEU104-ARG116 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0000269|PubMed:3342873, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:25944712 |
| Chain | Residue | Details |
| P | ALA1 | |
| N | ARG90 | |
| N | VAL141 | |
| N | SER149 | |
| N | MET179 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P62963 |
| Chain | Residue | Details |
| P | SER27 | |
| A | MET47 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| P | SER56 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| P | SER84 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| P | LYS104 | |
| P | LYS107 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455 |
| Chain | Residue | Details |
| P | TYR128 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by ROCK1 => ECO:0000269|PubMed:18573880 |
| Chain | Residue | Details |
| P | SER137 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate |
| Chain | Residue | Details |
| P | LYS53 |
