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6NAY

Crystal structure of Neisseria meningitidis ClpP protease E31A+E58A activated double mutant

Functional Information from GO Data
ChainGOidnamespacecontents
A0004176molecular_functionATP-dependent peptidase activity
A0004252molecular_functionserine-type endopeptidase activity
A0005737cellular_componentcytoplasm
A0006508biological_processproteolysis
A0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
A0008236molecular_functionserine-type peptidase activity
A0009368cellular_componentendopeptidase Clp complex
A0051117molecular_functionATPase binding
B0004176molecular_functionATP-dependent peptidase activity
B0004252molecular_functionserine-type endopeptidase activity
B0005737cellular_componentcytoplasm
B0006508biological_processproteolysis
B0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
B0008236molecular_functionserine-type peptidase activity
B0009368cellular_componentendopeptidase Clp complex
B0051117molecular_functionATPase binding
C0004176molecular_functionATP-dependent peptidase activity
C0004252molecular_functionserine-type endopeptidase activity
C0005737cellular_componentcytoplasm
C0006508biological_processproteolysis
C0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
C0008236molecular_functionserine-type peptidase activity
C0009368cellular_componentendopeptidase Clp complex
C0051117molecular_functionATPase binding
D0004176molecular_functionATP-dependent peptidase activity
D0004252molecular_functionserine-type endopeptidase activity
D0005737cellular_componentcytoplasm
D0006508biological_processproteolysis
D0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
D0008236molecular_functionserine-type peptidase activity
D0009368cellular_componentendopeptidase Clp complex
D0051117molecular_functionATPase binding
E0004176molecular_functionATP-dependent peptidase activity
E0004252molecular_functionserine-type endopeptidase activity
E0005737cellular_componentcytoplasm
E0006508biological_processproteolysis
E0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
E0008236molecular_functionserine-type peptidase activity
E0009368cellular_componentendopeptidase Clp complex
E0051117molecular_functionATPase binding
F0004176molecular_functionATP-dependent peptidase activity
F0004252molecular_functionserine-type endopeptidase activity
F0005737cellular_componentcytoplasm
F0006508biological_processproteolysis
F0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
F0008236molecular_functionserine-type peptidase activity
F0009368cellular_componentendopeptidase Clp complex
F0051117molecular_functionATPase binding
G0004176molecular_functionATP-dependent peptidase activity
G0004252molecular_functionserine-type endopeptidase activity
G0005737cellular_componentcytoplasm
G0006508biological_processproteolysis
G0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
G0008236molecular_functionserine-type peptidase activity
G0009368cellular_componentendopeptidase Clp complex
G0051117molecular_functionATPase binding
H0004176molecular_functionATP-dependent peptidase activity
H0004252molecular_functionserine-type endopeptidase activity
H0005737cellular_componentcytoplasm
H0006508biological_processproteolysis
H0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
H0008236molecular_functionserine-type peptidase activity
H0009368cellular_componentendopeptidase Clp complex
H0051117molecular_functionATPase binding
I0004176molecular_functionATP-dependent peptidase activity
I0004252molecular_functionserine-type endopeptidase activity
I0005737cellular_componentcytoplasm
I0006508biological_processproteolysis
I0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
I0008236molecular_functionserine-type peptidase activity
I0009368cellular_componentendopeptidase Clp complex
I0051117molecular_functionATPase binding
J0004176molecular_functionATP-dependent peptidase activity
J0004252molecular_functionserine-type endopeptidase activity
J0005737cellular_componentcytoplasm
J0006508biological_processproteolysis
J0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
J0008236molecular_functionserine-type peptidase activity
J0009368cellular_componentendopeptidase Clp complex
J0051117molecular_functionATPase binding
K0004176molecular_functionATP-dependent peptidase activity
K0004252molecular_functionserine-type endopeptidase activity
K0005737cellular_componentcytoplasm
K0006508biological_processproteolysis
K0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
K0008236molecular_functionserine-type peptidase activity
K0009368cellular_componentendopeptidase Clp complex
K0051117molecular_functionATPase binding
L0004176molecular_functionATP-dependent peptidase activity
L0004252molecular_functionserine-type endopeptidase activity
L0005737cellular_componentcytoplasm
L0006508biological_processproteolysis
L0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
L0008236molecular_functionserine-type peptidase activity
L0009368cellular_componentendopeptidase Clp complex
L0051117molecular_functionATPase binding
M0004176molecular_functionATP-dependent peptidase activity
M0004252molecular_functionserine-type endopeptidase activity
M0005737cellular_componentcytoplasm
M0006508biological_processproteolysis
M0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
M0008236molecular_functionserine-type peptidase activity
M0009368cellular_componentendopeptidase Clp complex
M0051117molecular_functionATPase binding
N0004176molecular_functionATP-dependent peptidase activity
N0004252molecular_functionserine-type endopeptidase activity
N0005737cellular_componentcytoplasm
N0006508biological_processproteolysis
N0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
N0008236molecular_functionserine-type peptidase activity
N0009368cellular_componentendopeptidase Clp complex
N0051117molecular_functionATPase binding
O0004176molecular_functionATP-dependent peptidase activity
O0004252molecular_functionserine-type endopeptidase activity
O0005737cellular_componentcytoplasm
O0006508biological_processproteolysis
O0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
O0008236molecular_functionserine-type peptidase activity
O0009368cellular_componentendopeptidase Clp complex
O0051117molecular_functionATPase binding
P0004176molecular_functionATP-dependent peptidase activity
P0004252molecular_functionserine-type endopeptidase activity
P0005737cellular_componentcytoplasm
P0006508biological_processproteolysis
P0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
P0008236molecular_functionserine-type peptidase activity
P0009368cellular_componentendopeptidase Clp complex
P0051117molecular_functionATPase binding
Q0004176molecular_functionATP-dependent peptidase activity
Q0004252molecular_functionserine-type endopeptidase activity
Q0005737cellular_componentcytoplasm
Q0006508biological_processproteolysis
Q0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
Q0008236molecular_functionserine-type peptidase activity
Q0009368cellular_componentendopeptidase Clp complex
Q0051117molecular_functionATPase binding
R0004176molecular_functionATP-dependent peptidase activity
R0004252molecular_functionserine-type endopeptidase activity
R0005737cellular_componentcytoplasm
R0006508biological_processproteolysis
R0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
R0008236molecular_functionserine-type peptidase activity
R0009368cellular_componentendopeptidase Clp complex
R0051117molecular_functionATPase binding
S0004176molecular_functionATP-dependent peptidase activity
S0004252molecular_functionserine-type endopeptidase activity
S0005737cellular_componentcytoplasm
S0006508biological_processproteolysis
S0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
S0008236molecular_functionserine-type peptidase activity
S0009368cellular_componentendopeptidase Clp complex
S0051117molecular_functionATPase binding
T0004176molecular_functionATP-dependent peptidase activity
T0004252molecular_functionserine-type endopeptidase activity
T0005737cellular_componentcytoplasm
T0006508biological_processproteolysis
T0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
T0008236molecular_functionserine-type peptidase activity
T0009368cellular_componentendopeptidase Clp complex
T0051117molecular_functionATPase binding
U0004176molecular_functionATP-dependent peptidase activity
U0004252molecular_functionserine-type endopeptidase activity
U0005737cellular_componentcytoplasm
U0006508biological_processproteolysis
U0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
U0008236molecular_functionserine-type peptidase activity
U0009368cellular_componentendopeptidase Clp complex
U0051117molecular_functionATPase binding
V0004176molecular_functionATP-dependent peptidase activity
V0004252molecular_functionserine-type endopeptidase activity
V0005737cellular_componentcytoplasm
V0006508biological_processproteolysis
V0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
V0008236molecular_functionserine-type peptidase activity
V0009368cellular_componentendopeptidase Clp complex
V0051117molecular_functionATPase binding
W0004176molecular_functionATP-dependent peptidase activity
W0004252molecular_functionserine-type endopeptidase activity
W0005737cellular_componentcytoplasm
W0006508biological_processproteolysis
W0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
W0008236molecular_functionserine-type peptidase activity
W0009368cellular_componentendopeptidase Clp complex
W0051117molecular_functionATPase binding
X0004176molecular_functionATP-dependent peptidase activity
X0004252molecular_functionserine-type endopeptidase activity
X0005737cellular_componentcytoplasm
X0006508biological_processproteolysis
X0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
X0008236molecular_functionserine-type peptidase activity
X0009368cellular_componentendopeptidase Clp complex
X0051117molecular_functionATPase binding
Y0004176molecular_functionATP-dependent peptidase activity
Y0004252molecular_functionserine-type endopeptidase activity
Y0005737cellular_componentcytoplasm
Y0006508biological_processproteolysis
Y0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
Y0008236molecular_functionserine-type peptidase activity
Y0009368cellular_componentendopeptidase Clp complex
Y0051117molecular_functionATPase binding
Z0004176molecular_functionATP-dependent peptidase activity
Z0004252molecular_functionserine-type endopeptidase activity
Z0005737cellular_componentcytoplasm
Z0006508biological_processproteolysis
Z0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
Z0008236molecular_functionserine-type peptidase activity
Z0009368cellular_componentendopeptidase Clp complex
Z0051117molecular_functionATPase binding
a0004176molecular_functionATP-dependent peptidase activity
a0004252molecular_functionserine-type endopeptidase activity
a0005737cellular_componentcytoplasm
a0006508biological_processproteolysis
a0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
a0008236molecular_functionserine-type peptidase activity
a0009368cellular_componentendopeptidase Clp complex
a0051117molecular_functionATPase binding
b0004176molecular_functionATP-dependent peptidase activity
b0004252molecular_functionserine-type endopeptidase activity
b0005737cellular_componentcytoplasm
b0006508biological_processproteolysis
b0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
b0008236molecular_functionserine-type peptidase activity
b0009368cellular_componentendopeptidase Clp complex
b0051117molecular_functionATPase binding
Functional Information from PROSITE/UniProt
site_idPS00381
Number of Residues12
DetailsCLP_PROTEASE_SER Endopeptidase Clp serine active site. TlcLGqAASMGA
ChainResidueDetails
ATHR94-ALA105

site_idPS00382
Number of Residues14
DetailsCLP_PROTEASE_HIS Endopeptidase Clp histidine active site. RfalPnsrIMIHQP
ChainResidueDetails
AARG116-PRO129

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues28
DetailsACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_00444
ChainResidueDetails
ASER102
BSER102
CSER102
DSER102
ESER102
FSER102
GSER102
HSER102
ISER102
JSER102
KSER102
LSER102
MSER102
NSER102
OSER102
PSER102
QSER102
RSER102
SSER102
TSER102
USER102
VSER102
WSER102
XSER102
YSER102
ZSER102
aSER102
bSER102

site_idSWS_FT_FI2
Number of Residues28
DetailsACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00444
ChainResidueDetails
AHIS127
BHIS127
CHIS127
DHIS127
EHIS127
FHIS127
GHIS127
HHIS127
IHIS127
JHIS127
KHIS127
LHIS127
MHIS127
NHIS127
OHIS127
PHIS127
QHIS127
RHIS127
SHIS127
THIS127
UHIS127
VHIS127
WHIS127
XHIS127
YHIS127
ZHIS127
aHIS127
bHIS127

220472

PDB entries from 2024-05-29

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