6NAB
Crystal structure of prolyl-tRNA synthetase from Naegleria fowleri in complex with proline and adenosine monophophsphate (AMP)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004827 | molecular_function | proline-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006433 | biological_process | prolyl-tRNA aminoacylation |
| A | 0016874 | molecular_function | ligase activity |
| A | 0017101 | cellular_component | aminoacyl-tRNA synthetase multienzyme complex |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004827 | molecular_function | proline-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006412 | biological_process | translation |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006433 | biological_process | prolyl-tRNA aminoacylation |
| B | 0016874 | molecular_function | ligase activity |
| B | 0017101 | cellular_component | aminoacyl-tRNA synthetase multienzyme complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue AMP A 601 |
| Chain | Residue |
| A | ARG142 |
| A | THR230 |
| A | GLY262 |
| A | LEU263 |
| A | SER264 |
| A | ARG266 |
| A | PRO602 |
| A | HOH701 |
| A | HOH733 |
| A | HOH798 |
| A | HOH852 |
| A | GLU144 |
| A | PHE151 |
| A | ILE152 |
| A | ARG153 |
| A | SER154 |
| A | PHE157 |
| A | GLN227 |
| A | GLY229 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue PRO A 602 |
| Chain | Residue |
| A | THR111 |
| A | GLU113 |
| A | ARG142 |
| A | TRP159 |
| A | GLU161 |
| A | PHE206 |
| A | HIS232 |
| A | SER260 |
| A | TRP261 |
| A | GLY262 |
| A | AMP601 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 603 |
| Chain | Residue |
| A | HOH701 |
| A | HOH714 |
| A | HOH733 |
| A | HOH780 |
| A | HOH1008 |
| A | HOH1111 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 604 |
| Chain | Residue |
| A | ARG286 |
| A | LYS387 |
| A | ASP391 |
| A | HOH784 |
| A | HOH809 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 605 |
| Chain | Residue |
| A | TYR30 |
| A | TYR31 |
| A | VAL33 |
| A | SER34 |
| A | GLY35 |
| A | CYS36 |
| A | TYR37 |
| B | HIS492 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 606 |
| Chain | Residue |
| A | ARG367 |
| A | GLU372 |
| A | TRP374 |
| A | LYS392 |
| A | HOH876 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 607 |
| Chain | Residue |
| A | PHE14 |
| A | SER15 |
| A | TYR505 |
| A | HOH777 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 608 |
| Chain | Residue |
| A | VAL274 |
| A | GLY276 |
| A | ASP277 |
| A | LYS400 |
| A | HOH773 |
| A | HOH822 |
| A | HOH908 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 609 |
| Chain | Residue |
| A | ARG40 |
| A | PRO41 |
| A | HOH855 |
| A | HOH923 |
| B | LEU132 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 610 |
| Chain | Residue |
| A | LYS74 |
| A | TRP93 |
| B | GLY98 |
| site_id | AD2 |
| Number of Residues | 19 |
| Details | binding site for residue AMP B 601 |
| Chain | Residue |
| B | ARG142 |
| B | GLU144 |
| B | PHE151 |
| B | ILE152 |
| B | ARG153 |
| B | SER154 |
| B | PHE157 |
| B | GLN227 |
| B | GLY229 |
| B | THR230 |
| B | GLY262 |
| B | LEU263 |
| B | SER264 |
| B | ARG266 |
| B | PRO602 |
| B | HOH707 |
| B | HOH786 |
| B | HOH849 |
| B | HOH941 |
| site_id | AD3 |
| Number of Residues | 11 |
| Details | binding site for residue PRO B 602 |
| Chain | Residue |
| B | SER260 |
| B | TRP261 |
| B | GLY262 |
| B | AMP601 |
| B | THR111 |
| B | GLU113 |
| B | ARG142 |
| B | TRP159 |
| B | GLU161 |
| B | PHE206 |
| B | HIS232 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 603 |
| Chain | Residue |
| B | HOH707 |
| B | HOH761 |
| B | HOH786 |
| B | HOH788 |
| B | HOH949 |
| B | HOH1053 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 604 |
| Chain | Residue |
| B | ARG286 |
| B | LYS387 |
| B | ASP391 |
| B | HOH746 |
| site_id | AD6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 605 |
| Chain | Residue |
| B | TYR30 |
| B | TYR31 |
| B | VAL33 |
| B | SER34 |
| B | GLY35 |
| B | CYS36 |
| B | TYR37 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 606 |
| Chain | Residue |
| B | ARG367 |
| B | GLU372 |
| B | TRP374 |
| B | LYS392 |
| site_id | AD8 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 607 |
| Chain | Residue |
| B | PHE14 |
| B | SER15 |
| B | TYR18 |
| B | MET273 |
| B | TYR505 |
| B | HOH732 |
| B | HOH816 |
| site_id | AD9 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 608 |
| Chain | Residue |
| B | LYS10 |
| B | VAL274 |
| B | GLY276 |
| B | LYS400 |
| B | HOH752 |
| B | HOH799 |
| B | HOH834 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 609 |
| Chain | Residue |
| A | TRP123 |
| A | LEU132 |
| B | ARG40 |
| B | PRO41 |
| B | HOH888 |
