6N9M
Crystal Structure of Adenosine Deaminase from Salmonella typhimurium with Pentostatin (Deoxycoformycin)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004000 | molecular_function | adenosine deaminase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006154 | biological_process | adenosine catabolic process |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0009117 | biological_process | nucleotide metabolic process |
| A | 0009168 | biological_process | purine ribonucleoside monophosphate biosynthetic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019239 | molecular_function | deaminase activity |
| A | 0043103 | biological_process | hypoxanthine salvage |
| A | 0046103 | biological_process | inosine biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0046936 | molecular_function | 2'-deoxyadenosine deaminase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue DCF A 401 |
| Chain | Residue |
| A | HIS12 |
| A | HIS197 |
| A | GLU200 |
| A | HIS221 |
| A | ASP278 |
| A | ASP279 |
| A | ZN402 |
| A | HOH523 |
| A | HIS14 |
| A | ASP16 |
| A | LEU56 |
| A | LEU60 |
| A | ILE139 |
| A | SER141 |
| A | ALA169 |
| A | GLY170 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 402 |
| Chain | Residue |
| A | HIS12 |
| A | HIS14 |
| A | HIS197 |
| A | ASP278 |
| A | DCF401 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 403 |
| Chain | Residue |
| A | GLU117 |
| A | GLU328 |
| A | HOH568 |
| A | HOH667 |
| A | HOH676 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 404 |
| Chain | Residue |
| A | GLY131 |
| A | GLU133 |
| A | GLU161 |
| A | HOH611 |
| A | HOH675 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue FMT A 405 |
| Chain | Residue |
| A | ARG29 |
| A | ASN32 |
Functional Information from PROSITE/UniProt
| site_id | PS00485 |
| Number of Residues | 7 |
| Details | A_DEAMINASE Adenosine and AMP deaminase signature. SLNTDDP |
| Chain | Residue | Details |
| A | SER274-PRO280 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"HAMAP-Rule","id":"MF_00540","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00540","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2018","submissionDatabase":"PDB data bank","title":"Crystal structure of adenosine deaminase from Salmonella typhimurium complexed with pentostatin (deoxycoformycin) (CASP target).","authors":["Maltseva N.","Kim Y.","Grimshaw S.","Joachimiak A."]}},{"source":"PDB","id":"6N9M","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2018","submissionDatabase":"PDB data bank","title":"Crystal structure of adenosine deaminase from Salmonella typhimurium complexed with pentostatin (deoxycoformycin) (CASP target).","authors":["Maltseva N.","Kim Y.","Grimshaw S.","Joachimiak A."]}},{"source":"PDB","id":"6N9M","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00540","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for catalytic activity","evidences":[{"source":"HAMAP-Rule","id":"MF_00540","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
