6N9G
Crystal Structure of RGS7-Gbeta5 dimer
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001965 | molecular_function | G-protein alpha-subunit binding |
| A | 0005096 | molecular_function | GTPase activator activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0008277 | biological_process | regulation of G protein-coupled receptor signaling pathway |
| A | 0009968 | biological_process | negative regulation of signal transduction |
| A | 0016020 | cellular_component | membrane |
| A | 0035556 | biological_process | intracellular signal transduction |
| A | 0043005 | cellular_component | neuron projection |
| A | 0045744 | biological_process | negative regulation of G protein-coupled receptor signaling pathway |
| B | 0001965 | molecular_function | G-protein alpha-subunit binding |
| B | 0005096 | molecular_function | GTPase activator activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0008277 | biological_process | regulation of G protein-coupled receptor signaling pathway |
| B | 0009968 | biological_process | negative regulation of signal transduction |
| B | 0016020 | cellular_component | membrane |
| B | 0035556 | biological_process | intracellular signal transduction |
| B | 0043005 | cellular_component | neuron projection |
| B | 0045744 | biological_process | negative regulation of G protein-coupled receptor signaling pathway |
| C | 0007165 | biological_process | signal transduction |
| D | 0007165 | biological_process | signal transduction |
Functional Information from PROSITE/UniProt
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. IVSSsqDgKVIVWDS |
| Chain | Residue | Details |
| C | ILE78-SER92 | |
| C | ILE168-VAL182 | |
| C | LEU298-VAL312 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 150 |
| Details | Domain: {"description":"DEP","evidences":[{"source":"PROSITE-ProRule","id":"PRU00066","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 122 |
| Details | Domain: {"description":"G protein gamma"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 230 |
| Details | Domain: {"description":"RGS","evidences":[{"source":"PROSITE-ProRule","id":"PRU00171","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P49802","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 78 |
| Details | Repeat: {"description":"WD 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 78 |
| Details | Repeat: {"description":"WD 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 82 |
| Details | Repeat: {"description":"WD 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 84 |
| Details | Repeat: {"description":"WD 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 78 |
| Details | Repeat: {"description":"WD 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 84 |
| Details | Repeat: {"description":"WD 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 58 |
| Details | Repeat: {"description":"WD 7"} |
| Chain | Residue | Details |
