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6N89

Cryo-EM structure of the Importin beta:Histone H1.0 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005635cellular_componentnuclear envelope
A0005643cellular_componentnuclear pore
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006404biological_processRNA import into nucleus
A0006606biological_processprotein import into nucleus
A0006607biological_processNLS-bearing protein import into nucleus
A0006610biological_processribosomal protein import into nucleus
A0006886biological_processintracellular protein transport
A0007079biological_processmitotic chromosome movement towards spindle pole
A0007080biological_processmitotic metaphase chromosome alignment
A0008139molecular_functionnuclear localization sequence binding
A0008270molecular_functionzinc ion binding
A0010494cellular_componentcytoplasmic stress granule
A0015031biological_processprotein transport
A0016020cellular_componentmembrane
A0019899molecular_functionenzyme binding
A0019904molecular_functionprotein domain specific binding
A0030953biological_processastral microtubule organization
A0031267molecular_functionsmall GTPase binding
A0031965cellular_componentnuclear membrane
A0032991cellular_componentprotein-containing complex
A0035580cellular_componentspecific granule lumen
A0040001biological_processestablishment of mitotic spindle localization
A0042564cellular_componentNLS-dependent protein nuclear import complex
A0045542biological_processpositive regulation of cholesterol biosynthetic process
A0051879molecular_functionHsp90 protein binding
A0061608molecular_functionnuclear import signal receptor activity
A0061676molecular_functionimportin-alpha family protein binding
A0070062cellular_componentextracellular exosome
A0071782cellular_componentendoplasmic reticulum tubular network
A0090307biological_processmitotic spindle assembly
A1904813cellular_componentficolin-1-rich granule lumen
B0000785cellular_componentchromatin
B0000786cellular_componentnucleosome
B0000791cellular_componenteuchromatin
B0003677molecular_functionDNA binding
B0003680molecular_functionminor groove of adenine-thymine-rich DNA binding
B0003690molecular_functiondouble-stranded DNA binding
B0003723molecular_functionRNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005694cellular_componentchromosome
B0005794cellular_componentGolgi apparatus
B0006334biological_processnucleosome assembly
B0015629cellular_componentactin cytoskeleton
B0016604cellular_componentnuclear body
B0017053cellular_componenttranscription repressor complex
B0030261biological_processchromosome condensation
B0030527molecular_functionstructural constituent of chromatin
B0031490molecular_functionchromatin DNA binding
B0031491molecular_functionnucleosome binding
B0031492molecular_functionnucleosomal DNA binding
B0031507biological_processheterochromatin formation
B0045910biological_processnegative regulation of DNA recombination
B2000679biological_processpositive regulation of transcription regulatory region DNA binding
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:19413330
ChainResidueDetails
BMET1

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N-acetylthreonine; partial; in Histone H1.0, N-terminally processed => ECO:0000269|PubMed:9582379, ECO:0007744|PubMed:19413330
ChainResidueDetails
BTHR2

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Deamidated asparagine; partial => ECO:0000269|PubMed:9582379
ChainResidueDetails
BASN4
ALYS835
ALYS867

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Citrulline => ECO:0000250|UniProtKB:P43275
ChainResidueDetails
BARG42

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: ADP-ribosylserine => ECO:0000269|PubMed:27723750
ChainResidueDetails
BSER104

227111

PDB entries from 2024-11-06

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