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6N83

Crystal structure of human FPPS in complex with an allosteric inhibitor YF-02037

Functional Information from GO Data
ChainGOidnamespacecontents
F0008299biological_processisoprenoid biosynthetic process
F0016765molecular_functiontransferase activity, transferring alkyl or aryl (other than methyl) groups
Functional Information from PDB Data
site_idAC1
Number of Residues14
Detailsbinding site for residue YL6 F 401
ChainResidue
FLYS57
FLYS350
FPO4402
FHOH520
FHOH523
FHOH542
FASN59
FARG60
FSER205
FPHE206
FPHE239
FGLN242
FASP243
FILE348

site_idAC2
Number of Residues7
Detailsbinding site for residue PO4 F 402
ChainResidue
FLYS57
FTYR58
FASN59
FARG60
FYL6401
FHOH501
FHOH504

site_idAC3
Number of Residues2
Detailsbinding site for residue CL F 403
ChainResidue
FPHE203
FLYS229

site_idAC4
Number of Residues1
Detailsbinding site for residue CL F 404
ChainResidue
FASP80

Functional Information from PROSITE/UniProt
site_idPS00444
Number of Residues13
DetailsPOLYPRENYL_SYNTHASE_2 Polyprenyl synthases signature 2. MGefFQIqDDYlD
ChainResidueDetails
FMET235-ASP247

site_idPS00723
Number of Residues15
DetailsPOLYPRENYL_SYNTHASE_1 Polyprenyl synthases signature 1. LVaDDim..DssltRRG
ChainResidueDetails
FLEU100-GLY114

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:16684881, ECO:0007744|PDB:1ZW5
ChainResidueDetails
FGLN96
FASP103
FASP107
FARG113
FLYS57
FARG60

site_idSWS_FT_FI2
Number of Residues5
DetailsBINDING:
ChainResidueDetails
FLYS257
FARG112
FLYS200
FTHR201
FGLN240

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
FLYS266

site_idSWS_FT_FI4
Number of Residues2
DetailsSITE: Important for determining product chain length => ECO:0000250
ChainResidueDetails
FPHE99
FPHE98

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
ChainResidueDetails
FLYS57

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
FLYS287

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PDB entries from 2024-06-12

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