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6N7Z

Crystal structure of human FPPS in complex with an allosteric inhibitor YF-02037

Functional Information from GO Data
ChainGOidnamespacecontents
F0004659molecular_functionprenyltransferase activity
F0008299biological_processisoprenoid biosynthetic process
F0016765molecular_functiontransferase activity, transferring alkyl or aryl (other than methyl) groups
Functional Information from PDB Data
site_idAC1
Number of Residues7
Detailsbinding site for residue GOL F 401
ChainResidue
FTYR140
FARG141
FTYR153
FGLU158
FGLN162
FHOH522
FHOH530

site_idAC2
Number of Residues7
Detailsbinding site for residue KF7 F 402
ChainResidue
FSER205
FPHE206
FASP243
FHOH512
FHOH535
FLYS57
FASN59

site_idAC3
Number of Residues1
Detailsbinding site for residue CL F 403
ChainResidue
FASP80

Functional Information from PROSITE/UniProt
site_idPS00444
Number of Residues13
DetailsPOLYPRENYL_SYNTHASE_2 Polyprenyl synthases signature 2. MGefFQIqDDYlD
ChainResidueDetails
FMET235-ASP247

site_idPS00723
Number of Residues15
DetailsPOLYPRENYL_SYNTHASE_1 Polyprenyl synthases signature 1. LVaDDim..DssltRRG
ChainResidueDetails
FLEU100-GLY114

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16684881","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ZW5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues5
DetailsBinding site: {}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues1
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues2
DetailsSite: {"description":"Important for determining product chain length","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

239149

PDB entries from 2025-07-23

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