Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6N7Y

Crystal structure of human FPPS in complex with an allosteric inhibitor MIT-01-102

Functional Information from GO Data
ChainGOidnamespacecontents
F0004659molecular_functionprenyltransferase activity
F0008299biological_processisoprenoid biosynthetic process
F0016765molecular_functiontransferase activity, transferring alkyl or aryl (other than methyl) groups
Functional Information from PDB Data
site_idAC1
Number of Residues7
Detailsbinding site for residue GOL F 401
ChainResidue
FGLU158
FLEU161
FGLN162
FHOH519
FHOH524
FHOH535
FHOH549

site_idAC2
Number of Residues7
Detailsbinding site for residue KFA F 402
ChainResidue
FGLN242
FLEU246
FLYS347
FHOH587
FHOH610
FASN59
FSER205

site_idAC3
Number of Residues7
Detailsbinding site for residue PO4 F 403
ChainResidue
FGLY56
FLYS57
FGLN96
FARG113
FHOH508
FHOH521
FHOH591

Functional Information from PROSITE/UniProt
site_idPS00444
Number of Residues13
DetailsPOLYPRENYL_SYNTHASE_2 Polyprenyl synthases signature 2. MGefFQIqDDYlD
ChainResidueDetails
FMET235-ASP247

site_idPS00723
Number of Residues15
DetailsPOLYPRENYL_SYNTHASE_1 Polyprenyl synthases signature 1. LVaDDim..DssltRRG
ChainResidueDetails
FLEU100-GLY114

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:16684881, ECO:0007744|PDB:1ZW5
ChainResidueDetails
FLYS57
FARG60
FGLN96
FASP103
FASP107
FARG113

site_idSWS_FT_FI2
Number of Residues5
DetailsBINDING:
ChainResidueDetails
FARG112
FLYS200
FTHR201
FGLN240
FLYS257

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
FLYS266

site_idSWS_FT_FI4
Number of Residues2
DetailsSITE: Important for determining product chain length => ECO:0000250
ChainResidueDetails
FPHE98
FPHE99

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
ChainResidueDetails
FLYS57

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
FLYS287

227561

PDB entries from 2024-11-20

PDB statisticsPDBj update infoContact PDBjnumon