6N7L
Crystal structure of an alcohol dehydrogenase from Elizabethkingia anophelis NUHP1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004022 | molecular_function | alcohol dehydrogenase (NAD+) activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004022 | molecular_function | alcohol dehydrogenase (NAD+) activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004022 | molecular_function | alcohol dehydrogenase (NAD+) activity |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0004022 | molecular_function | alcohol dehydrogenase (NAD+) activity |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0000166 | molecular_function | nucleotide binding |
| E | 0004022 | molecular_function | alcohol dehydrogenase (NAD+) activity |
| E | 0008270 | molecular_function | zinc ion binding |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0000166 | molecular_function | nucleotide binding |
| F | 0004022 | molecular_function | alcohol dehydrogenase (NAD+) activity |
| F | 0008270 | molecular_function | zinc ion binding |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| F | 0046872 | molecular_function | metal ion binding |
| G | 0000166 | molecular_function | nucleotide binding |
| G | 0004022 | molecular_function | alcohol dehydrogenase (NAD+) activity |
| G | 0008270 | molecular_function | zinc ion binding |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| G | 0046872 | molecular_function | metal ion binding |
| H | 0000166 | molecular_function | nucleotide binding |
| H | 0004022 | molecular_function | alcohol dehydrogenase (NAD+) activity |
| H | 0008270 | molecular_function | zinc ion binding |
| H | 0016491 | molecular_function | oxidoreductase activity |
| H | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| H | 0046872 | molecular_function | metal ion binding |
| I | 0000166 | molecular_function | nucleotide binding |
| I | 0004022 | molecular_function | alcohol dehydrogenase (NAD+) activity |
| I | 0008270 | molecular_function | zinc ion binding |
| I | 0016491 | molecular_function | oxidoreductase activity |
| I | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| I | 0046872 | molecular_function | metal ion binding |
| J | 0000166 | molecular_function | nucleotide binding |
| J | 0004022 | molecular_function | alcohol dehydrogenase (NAD+) activity |
| J | 0008270 | molecular_function | zinc ion binding |
| J | 0016491 | molecular_function | oxidoreductase activity |
| J | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| J | 0046872 | molecular_function | metal ion binding |
| K | 0000166 | molecular_function | nucleotide binding |
| K | 0004022 | molecular_function | alcohol dehydrogenase (NAD+) activity |
| K | 0008270 | molecular_function | zinc ion binding |
| K | 0016491 | molecular_function | oxidoreductase activity |
| K | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| K | 0046872 | molecular_function | metal ion binding |
| L | 0000166 | molecular_function | nucleotide binding |
| L | 0004022 | molecular_function | alcohol dehydrogenase (NAD+) activity |
| L | 0008270 | molecular_function | zinc ion binding |
| L | 0016491 | molecular_function | oxidoreductase activity |
| L | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| L | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 401 |
| Chain | Residue |
| A | ASP301 |
| A | PHE302 |
| A | GLU305 |
| A | LEU307 |
| A | HOH577 |
| A | HOH702 |
| C | GLY169 |
| C | HIS194 |
| site_id | AC2 |
| Number of Residues | 34 |
| Details | binding site for residue NAD A 402 |
| Chain | Residue |
| A | HIS44 |
| A | THR45 |
| A | HIS48 |
| A | CYS152 |
| A | THR156 |
| A | SER175 |
| A | GLY176 |
| A | ILE177 |
| A | GLY178 |
| A | GLY179 |
| A | LEU180 |
| A | ASP199 |
| A | VAL200 |
| A | LYS204 |
| A | THR241 |
| A | ALA242 |
| A | VAL243 |
| A | ALA247 |
| A | ASN264 |
| A | GLY265 |
| A | LEU266 |
| A | SER288 |
| A | ILE289 |
| A | VAL290 |
| A | ARG335 |
| A | EDO407 |
| A | ZN413 |
| A | HOH559 |
| A | HOH574 |
| A | HOH576 |
| A | HOH629 |
| A | HOH658 |
| D | VAL279 |
| A | CYS43 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 403 |
| Chain | Residue |
| A | LYS162 |
| A | GLU163 |
| A | HOH564 |
| A | HOH588 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 404 |
| Chain | Residue |
| A | ALA56 |
| A | TYR118 |
| A | HOH534 |
| A | HOH546 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 405 |
| Chain | Residue |
| A | GLY97 |
| A | CYS102 |
| A | ARG293 |
| A | EDO409 |
| B | GLY97 |
| B | ARG293 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 406 |
| Chain | Residue |
| A | ILE246 |
| A | LYS249 |
| A | PHE271 |
| A | GLU272 |
| A | HOH510 |
| J | LYS220 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 407 |
| Chain | Residue |
| A | ALA219 |
| A | ILE246 |
| A | GLN250 |
| A | NAD402 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 408 |
| Chain | Residue |
| A | VAL23 |
| A | LYS59 |
| A | PRO61 |
| A | ILE63 |
| A | ASP121 |
| A | HOH639 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 409 |
| Chain | Residue |
| A | ARG133 |
| A | TYR134 |
| A | ARG293 |
| A | EDO405 |
| A | HOH570 |
| B | GLY97 |
| B | CYS98 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 410 |
| Chain | Residue |
| A | CYS98 |
| A | CYS99 |
| A | ASP100 |
| A | ILE103 |
| B | GLN297 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 411 |
| Chain | Residue |
| A | THR216 |
| A | TYR227 |
| A | HOH608 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 412 |
| Chain | Residue |
| A | LYS189 |
| A | ALA190 |
| A | HOH509 |
| A | HOH516 |
| C | LYS189 |
| C | ALA190 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 413 |
| Chain | Residue |
| A | CYS43 |
| A | HIS66 |
| A | CYS152 |
| A | NAD402 |
| A | HOH567 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 414 |
| Chain | Residue |
| A | GLY97 |
| A | CYS99 |
| A | CYS102 |
| A | CYS110 |
| A | CYS96 |
| site_id | AD6 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 415 |
| Chain | Residue |
| A | LYS139 |
| site_id | AD7 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 401 |
| Chain | Residue |
| B | ASP301 |
| B | PHE302 |
| B | GLU305 |
| B | LEU307 |
| B | HOH503 |
| B | HOH662 |
| D | GLY169 |
| D | HIS194 |
| site_id | AD8 |
| Number of Residues | 37 |
| Details | binding site for residue NAD B 402 |
| Chain | Residue |
| B | CYS43 |
| B | HIS44 |
| B | THR45 |
| B | HIS48 |
| B | CYS152 |
| B | THR156 |
| B | SER175 |
| B | GLY176 |
| B | ILE177 |
| B | GLY178 |
| B | GLY179 |
| B | LEU180 |
| B | ASP199 |
| B | VAL200 |
| B | LYS204 |
| B | THR241 |
| B | ALA242 |
| B | VAL243 |
| B | ALA247 |
| B | ASN264 |
| B | GLY265 |
| B | LEU266 |
| B | SER288 |
| B | ILE289 |
| B | VAL290 |
| B | ARG335 |
| B | EDO407 |
| B | ZN409 |
| B | HOH554 |
| B | HOH559 |
| B | HOH582 |
| B | HOH595 |
| B | HOH597 |
| B | HOH624 |
| B | HOH636 |
| B | HOH641 |
| C | VAL279 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 403 |
| Chain | Residue |
| B | ALA56 |
| B | ASN115 |
| B | TYR118 |
| B | HOH531 |
| B | HOH665 |
| C | EDO408 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 404 |
| Chain | Residue |
| B | PRO245 |
| B | LYS249 |
| B | GLU272 |
| B | HOH577 |
| G | LYS220 |
| site_id | AE2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 405 |
| Chain | Residue |
| B | MET6 |
| B | ARG26 |
| B | ASP121 |
| B | HOH661 |
| site_id | AE3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 406 |
| Chain | Residue |
| B | LYS189 |
| B | GLY192 |
| B | HOH507 |
| D | LYS189 |
| D | GLY192 |
| D | HOH622 |
| D | HOH643 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 407 |
| Chain | Residue |
| B | ALA219 |
| B | ILE246 |
| B | GLN250 |
| B | NAD402 |
| site_id | AE5 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 408 |
| Chain | Residue |
| B | LYS59 |
| B | ASP121 |
| site_id | AE6 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 409 |
| Chain | Residue |
| B | CYS43 |
| B | HIS66 |
| B | CYS152 |
| B | NAD402 |
| B | HOH643 |
| site_id | AE7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 410 |
| Chain | Residue |
| B | CYS96 |
| B | CYS99 |
| B | CYS102 |
| B | CYS110 |
| site_id | AE8 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 411 |
| Chain | Residue |
| B | LYS139 |
| site_id | AE9 |
| Number of Residues | 7 |
| Details | binding site for residue EDO C 401 |
| Chain | Residue |
| A | GLY169 |
| A | HIS194 |
| C | ASP301 |
| C | GLU305 |
| C | HOH568 |
| C | HOH687 |
| C | HOH732 |
| site_id | AF1 |
| Number of Residues | 37 |
| Details | binding site for residue NAD C 402 |
| Chain | Residue |
| B | VAL279 |
| C | CYS43 |
| C | HIS44 |
| C | THR45 |
| C | HIS48 |
| C | CYS152 |
| C | THR156 |
| C | SER175 |
| C | GLY176 |
| C | ILE177 |
| C | GLY178 |
| C | GLY179 |
| C | LEU180 |
| C | ASP199 |
| C | VAL200 |
| C | LYS204 |
| C | THR241 |
| C | ALA242 |
| C | VAL243 |
| C | SER244 |
| C | ALA247 |
| C | ASN264 |
| C | GLY265 |
| C | LEU266 |
| C | SER288 |
| C | ILE289 |
| C | VAL290 |
| C | ARG335 |
| C | ZN414 |
| C | HOH520 |
| C | HOH555 |
| C | HOH571 |
| C | HOH573 |
| C | HOH608 |
| C | HOH629 |
| C | HOH680 |
| C | HOH703 |
| site_id | AF2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO C 403 |
| Chain | Residue |
| C | ALA56 |
| C | ASN115 |
| C | TYR118 |
| C | HOH503 |
| C | HOH549 |
| site_id | AF3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO C 404 |
| Chain | Residue |
| C | MET6 |
| C | ARG26 |
| C | ASP121 |
| C | HOH548 |
| C | HOH694 |
| site_id | AF4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO C 405 |
| Chain | Residue |
| C | THR216 |
| C | THR222 |
| C | TYR227 |
| C | HOH509 |
| C | HOH600 |
| site_id | AF5 |
| Number of Residues | 7 |
| Details | binding site for residue EDO C 406 |
| Chain | Residue |
| B | TYR101 |
| B | GLU111 |
| C | HIS229 |
| C | ARG256 |
| C | ARG257 |
| C | LYS281 |
| C | HOH512 |
| site_id | AF6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 407 |
| Chain | Residue |
| C | CYS96 |
| C | ALA112 |
| C | HOH599 |
| C | HOH731 |
| site_id | AF7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO C 408 |
| Chain | Residue |
| B | EDO403 |
| C | ARG257 |
| C | PHE276 |
| C | LYS281 |
| C | HOH512 |
| site_id | AF8 |
| Number of Residues | 2 |
| Details | binding site for residue EDO C 409 |
| Chain | Residue |
| C | MET38 |
| C | ASP339 |
| site_id | AF9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 410 |
| Chain | Residue |
| C | LYS59 |
| C | ASP121 |
| C | HOH691 |
| site_id | AG1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO C 411 |
| Chain | Residue |
| C | LYS162 |
| C | GLU163 |
| C | ARG286 |
| C | HOH616 |
| C | HOH672 |
| site_id | AG2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 412 |
| Chain | Residue |
| C | LYS209 |
| C | ALA213 |
| C | ASP214 |
| C | THR216 |
| site_id | AG3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO C 413 |
| Chain | Residue |
| C | ALA219 |
| C | ILE246 |
| C | GLN250 |
| C | HOH555 |
| F | SER270 |
| F | GLU272 |
| F | EDO404 |
| site_id | AG4 |
| Number of Residues | 5 |
| Details | binding site for residue ZN C 414 |
| Chain | Residue |
| C | CYS43 |
| C | HIS66 |
| C | CYS152 |
| C | NAD402 |
| C | HOH630 |
| site_id | AG5 |
| Number of Residues | 5 |
| Details | binding site for residue ZN C 415 |
| Chain | Residue |
| C | CYS96 |
| C | GLY97 |
| C | CYS99 |
| C | CYS102 |
| C | CYS110 |
| site_id | AG6 |
| Number of Residues | 1 |
| Details | binding site for residue CL C 416 |
| Chain | Residue |
| C | LYS139 |
| site_id | AG7 |
| Number of Residues | 40 |
| Details | binding site for residue NAD D 501 |
| Chain | Residue |
| A | VAL279 |
| D | CYS43 |
| D | HIS44 |
| D | THR45 |
| D | HIS48 |
| D | CYS152 |
| D | THR156 |
| D | SER175 |
| D | GLY176 |
| D | ILE177 |
| D | GLY178 |
| D | GLY179 |
| D | LEU180 |
| D | ASP199 |
| D | VAL200 |
| D | LYS204 |
| D | THR241 |
| D | ALA242 |
| D | VAL243 |
| D | SER244 |
| D | ILE246 |
| D | ALA247 |
| D | ASN264 |
| D | GLY265 |
| D | LEU266 |
| D | SER288 |
| D | ILE289 |
| D | VAL290 |
| D | MET327 |
| D | ARG335 |
| D | ZN510 |
| D | HOH633 |
| D | HOH642 |
| D | HOH647 |
| D | HOH669 |
| D | HOH671 |
| D | HOH677 |
| D | HOH679 |
| D | HOH723 |
| D | HOH758 |
| site_id | AG8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 502 |
| Chain | Residue |
| D | ALA56 |
| D | TYR118 |
| D | HOH640 |
| D | HOH661 |
| site_id | AG9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO D 503 |
| Chain | Residue |
| C | GLY97 |
| C | CYS102 |
| D | GLY97 |
| D | CYS102 |
| D | ARG293 |
| D | HOH683 |
| site_id | AH1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 504 |
| Chain | Residue |
| B | GLY169 |
| B | HIS194 |
| D | GLU305 |
| D | HOH722 |
| site_id | AH2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 505 |
| Chain | Residue |
| D | VAL23 |
| D | LYS59 |
| D | PRO61 |
| D | ASP121 |
| site_id | AH3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 506 |
| Chain | Residue |
| D | ARG26 |
| D | ASP121 |
| D | HOH721 |
| site_id | AH4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 507 |
| Chain | Residue |
| D | MET38 |
| D | ASP339 |
| D | GLY342 |
| site_id | AH5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 508 |
| Chain | Residue |
| A | HOH667 |
| D | LYS162 |
| D | GLU163 |
| D | HOH638 |
| site_id | AH6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO D 509 |
| Chain | Residue |
| D | ASP203 |
| D | LEU207 |
| D | LYS210 |
| D | ASP333 |
| D | HOH731 |
| site_id | AH7 |
| Number of Residues | 5 |
| Details | binding site for residue ZN D 510 |
| Chain | Residue |
| D | CYS43 |
| D | HIS66 |
| D | CYS152 |
| D | NAD501 |
| D | HOH669 |
| site_id | AH8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 511 |
| Chain | Residue |
| D | CYS96 |
| D | CYS99 |
| D | CYS102 |
| D | CYS110 |
| site_id | AH9 |
| Number of Residues | 1 |
| Details | binding site for residue CL D 512 |
| Chain | Residue |
| D | LYS139 |
| site_id | AI1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO E 401 |
| Chain | Residue |
| E | GLU305 |
| G | GLY169 |
| G | HIS194 |
| G | HOH676 |
| site_id | AI2 |
| Number of Residues | 32 |
| Details | binding site for residue NAD E 402 |
| Chain | Residue |
| E | CYS43 |
| E | HIS44 |
| E | THR45 |
| E | HIS48 |
| E | CYS152 |
| E | THR156 |
| E | SER175 |
| E | GLY176 |
| E | ILE177 |
| E | GLY178 |
| E | GLY179 |
| E | LEU180 |
| E | ASP199 |
| E | VAL200 |
| E | THR241 |
| E | ALA242 |
| E | VAL243 |
| E | ALA247 |
| E | ASN264 |
| E | GLY265 |
| E | LEU266 |
| E | SER288 |
| E | ILE289 |
| E | VAL290 |
| E | ARG335 |
| E | ZN411 |
| E | HOH507 |
| E | HOH528 |
| E | HOH557 |
| E | HOH567 |
| E | HOH614 |
| H | VAL279 |
| site_id | AI3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO E 403 |
| Chain | Residue |
| E | ASP100 |
| E | THR104 |
| E | TRP106 |
| E | HOH612 |
| H | LYS258 |
| site_id | AI4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO E 404 |
| Chain | Residue |
| E | ALA56 |
| E | ASN115 |
| E | TYR118 |
| site_id | AI5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO E 405 |
| Chain | Residue |
| E | GLY97 |
| E | CYS102 |
| E | ARG293 |
| F | GLY97 |
| F | CYS102 |
| F | ARG293 |
| site_id | AI6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO E 406 |
| Chain | Residue |
| E | PRO245 |
| E | LYS249 |
| E | GLU272 |
| E | HOH627 |
| E | HOH643 |
| site_id | AI7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO E 407 |
| Chain | Residue |
| E | VAL142 |
| E | ASN143 |
| E | ILE147 |
| E | ASN304 |
| E | CL413 |
| site_id | AI8 |
| Number of Residues | 1 |
| Details | binding site for residue EDO E 408 |
| Chain | Residue |
| E | ARG257 |
| site_id | AI9 |
| Number of Residues | 7 |
| Details | binding site for residue EDO E 409 |
| Chain | Residue |
| E | LYS189 |
| E | GLY192 |
| E | HOH513 |
| G | LYS189 |
| G | GLY192 |
| G | HOH635 |
| G | HOH721 |
| site_id | AJ1 |
| Number of Residues | 7 |
| Details | binding site for residue EDO E 410 |
| Chain | Residue |
| E | GLY169 |
| E | HIS194 |
| E | HOH501 |
| E | HOH536 |
| G | PHE302 |
| G | GLU305 |
| G | LEU307 |
| site_id | AJ2 |
| Number of Residues | 5 |
| Details | binding site for residue ZN E 411 |
| Chain | Residue |
| E | CYS43 |
| E | HIS66 |
| E | CYS152 |
| E | NAD402 |
| E | HOH603 |
| site_id | AJ3 |
| Number of Residues | 5 |
| Details | binding site for residue ZN E 412 |
| Chain | Residue |
| E | CYS96 |
| E | GLY97 |
| E | CYS99 |
| E | CYS102 |
| E | CYS110 |
| site_id | AJ4 |
| Number of Residues | 2 |
| Details | binding site for residue CL E 413 |
| Chain | Residue |
| E | LYS139 |
| E | EDO407 |
| site_id | AJ5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO F 401 |
| Chain | Residue |
| F | ASP301 |
| F | GLU305 |
| F | HOH558 |
| F | HOH599 |
| H | GLY169 |
| H | HIS194 |
| site_id | AJ6 |
| Number of Residues | 38 |
| Details | binding site for residue NAD F 402 |
| Chain | Residue |
| F | CYS43 |
| F | HIS44 |
| F | THR45 |
| F | HIS48 |
| F | CYS152 |
| F | THR156 |
| F | SER175 |
| F | GLY176 |
| F | ILE177 |
| F | GLY178 |
| F | GLY179 |
| F | LEU180 |
| F | ASP199 |
| F | VAL200 |
| F | LYS204 |
| F | THR241 |
| F | ALA242 |
| F | VAL243 |
| F | ALA247 |
| F | ASN264 |
| F | GLY265 |
| F | LEU266 |
| F | SER288 |
| F | ILE289 |
| F | VAL290 |
| F | ARG335 |
| F | EDO405 |
| F | ZN412 |
| F | HOH520 |
| F | HOH551 |
| F | HOH580 |
| F | HOH595 |
| F | HOH602 |
| F | HOH619 |
| F | HOH626 |
| F | HOH634 |
| F | HOH649 |
| G | VAL279 |
| site_id | AJ7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO F 403 |
| Chain | Residue |
| F | ASN115 |
| F | TYR118 |
| F | HOH552 |
| site_id | AJ8 |
| Number of Residues | 7 |
| Details | binding site for residue EDO F 404 |
| Chain | Residue |
| C | LYS220 |
| C | EDO413 |
| F | ILE246 |
| F | LYS249 |
| F | PHE271 |
| F | GLU272 |
| F | HOH503 |
| site_id | AJ9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO F 405 |
| Chain | Residue |
| F | ALA219 |
| F | ILE246 |
| F | GLN250 |
| F | NAD402 |
| site_id | AK1 |
| Number of Residues | 2 |
| Details | binding site for residue EDO F 406 |
| Chain | Residue |
| F | LYS59 |
| F | ASP121 |
| site_id | AK2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO F 407 |
| Chain | Residue |
| F | LYS162 |
| F | GLU163 |
| F | HOH628 |
| G | HOH732 |
| site_id | AK3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO F 408 |
| Chain | Residue |
| F | LYS189 |
| H | LYS189 |
| H | ALA190 |
| site_id | AK4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO F 409 |
| Chain | Residue |
| F | ARG257 |
| F | LYS281 |
| F | HOH506 |
| site_id | AK5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO F 410 |
| Chain | Residue |
| F | THR216 |
| F | TYR227 |
| F | HOH518 |
| site_id | AK6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO F 411 |
| Chain | Residue |
| F | HIS236 |
| F | ARG256 |
| F | ARG257 |
| F | LYS258 |
| F | HOH565 |
| F | HOH582 |
| G | TYR101 |
| site_id | AK7 |
| Number of Residues | 5 |
| Details | binding site for residue ZN F 412 |
| Chain | Residue |
| F | CYS43 |
| F | HIS66 |
| F | CYS152 |
| F | NAD402 |
| F | HOH580 |
| site_id | AK8 |
| Number of Residues | 5 |
| Details | binding site for residue ZN F 413 |
| Chain | Residue |
| F | CYS96 |
| F | GLY97 |
| F | CYS99 |
| F | CYS102 |
| F | CYS110 |
| site_id | AK9 |
| Number of Residues | 1 |
| Details | binding site for residue CL F 414 |
| Chain | Residue |
| F | LYS139 |
| site_id | AL1 |
| Number of Residues | 36 |
| Details | binding site for residue NAD G 501 |
| Chain | Residue |
| F | VAL279 |
| G | CYS43 |
| G | HIS44 |
| G | THR45 |
| G | HIS48 |
| G | CYS152 |
| G | THR156 |
| G | GLY176 |
| G | ILE177 |
| G | GLY178 |
| G | GLY179 |
| G | LEU180 |
| G | ASP199 |
| G | VAL200 |
| G | LYS204 |
| G | THR241 |
| G | ALA242 |
| G | VAL243 |
| G | SER244 |
| G | ALA247 |
| G | ASN264 |
| G | GLY265 |
| G | LEU266 |
| G | SER288 |
| G | ILE289 |
| G | VAL290 |
| G | ARG335 |
| G | ZN509 |
| G | HOH604 |
| G | HOH638 |
| G | HOH662 |
| G | HOH680 |
| G | HOH707 |
| G | HOH709 |
| G | HOH712 |
| G | HOH723 |
| site_id | AL2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO G 502 |
| Chain | Residue |
| G | GLY97 |
| G | CYS102 |
| G | ARG293 |
| H | GLY97 |
| H | CYS102 |
| H | ARG293 |
| site_id | AL3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO G 503 |
| Chain | Residue |
| B | PRO268 |
| G | THR222 |
| G | ASP223 |
| G | THR226 |
| G | TYR227 |
| G | LYS230 |
| site_id | AL4 |
| Number of Residues | 2 |
| Details | binding site for residue EDO G 504 |
| Chain | Residue |
| G | LYS59 |
| G | ASP121 |
| site_id | AL5 |
| Number of Residues | 2 |
| Details | binding site for residue EDO G 505 |
| Chain | Residue |
| G | ARG257 |
| G | HOH643 |
| site_id | AL6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO G 506 |
| Chain | Residue |
| G | MET38 |
| G | ASP339 |
| G | ALA341 |
| site_id | AL7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO G 507 |
| Chain | Residue |
| G | LYS209 |
| G | ALA213 |
| G | ASP214 |
| G | THR216 |
| site_id | AL8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO G 508 |
| Chain | Residue |
| G | THR216 |
| G | VAL217 |
| G | ASN218 |
| G | TYR227 |
| site_id | AL9 |
| Number of Residues | 5 |
| Details | binding site for residue ZN G 509 |
| Chain | Residue |
| G | CYS43 |
| G | HIS66 |
| G | CYS152 |
| G | NAD501 |
| G | HOH685 |
| site_id | AM1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN G 510 |
| Chain | Residue |
| G | CYS96 |
| G | CYS99 |
| G | CYS102 |
| G | CYS110 |
| site_id | AM2 |
| Number of Residues | 1 |
| Details | binding site for residue CL G 511 |
| Chain | Residue |
| G | LYS139 |
| site_id | AM3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO H 701 |
| Chain | Residue |
| E | HIS229 |
| E | ARG256 |
| E | ARG257 |
| E | LYS281 |
| E | HOH602 |
| H | TYR101 |
| H | GLU111 |
| site_id | AM4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO H 702 |
| Chain | Residue |
| F | GLY169 |
| F | HIS194 |
| H | GLU305 |
| H | HOH919 |
| H | HOH932 |
| site_id | AM5 |
| Number of Residues | 37 |
| Details | binding site for residue NAD H 703 |
| Chain | Residue |
| E | VAL279 |
| H | CYS43 |
| H | HIS44 |
| H | THR45 |
| H | HIS48 |
| H | CYS152 |
| H | THR156 |
| H | SER175 |
| H | GLY176 |
| H | ILE177 |
| H | GLY178 |
| H | GLY179 |
| H | LEU180 |
| H | ASP199 |
| H | VAL200 |
| H | LYS204 |
| H | THR241 |
| H | ALA242 |
| H | VAL243 |
| H | SER244 |
| H | ILE246 |
| H | ALA247 |
| H | ASN264 |
| H | GLY265 |
| H | LEU266 |
| H | SER288 |
| H | ILE289 |
| H | VAL290 |
| H | ARG335 |
| H | EDO705 |
| H | ZN708 |
| H | HOH827 |
| H | HOH836 |
| H | HOH880 |
| H | HOH892 |
| H | HOH904 |
| H | HOH945 |
| site_id | AM6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO H 704 |
| Chain | Residue |
| H | ALA56 |
| H | TYR118 |
| H | HOH854 |
| site_id | AM7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO H 705 |
| Chain | Residue |
| H | ALA219 |
| H | LYS220 |
| H | GLN250 |
| H | NAD703 |
| site_id | AM8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO H 707 |
| Chain | Residue |
| H | MET38 |
| H | ASP339 |
| H | GLY342 |
| site_id | AM9 |
| Number of Residues | 5 |
| Details | binding site for residue ZN H 708 |
| Chain | Residue |
| H | CYS43 |
| H | HIS66 |
| H | CYS152 |
| H | NAD703 |
| H | HOH880 |
| site_id | AN1 |
| Number of Residues | 5 |
| Details | binding site for residue ZN H 709 |
| Chain | Residue |
| H | CYS96 |
| H | GLY97 |
| H | CYS99 |
| H | CYS102 |
| H | CYS110 |
| site_id | AN2 |
| Number of Residues | 1 |
| Details | binding site for residue CL H 710 |
| Chain | Residue |
| H | LYS139 |
| site_id | AN3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO I 401 |
| Chain | Residue |
| I | ASP301 |
| I | GLU305 |
| I | HOH530 |
| K | GLY169 |
| K | HIS194 |
| site_id | AN4 |
| Number of Residues | 31 |
| Details | binding site for residue NAD I 402 |
| Chain | Residue |
| I | CYS43 |
| I | HIS44 |
| I | THR45 |
| I | HIS48 |
| I | CYS152 |
| I | THR156 |
| I | GLY176 |
| I | ILE177 |
| I | GLY178 |
| I | GLY179 |
| I | LEU180 |
| I | ASP199 |
| I | VAL200 |
| I | THR241 |
| I | ALA242 |
| I | VAL243 |
| I | ALA247 |
| I | ASN264 |
| I | GLY265 |
| I | LEU266 |
| I | SER288 |
| I | ILE289 |
| I | VAL290 |
| I | ARG335 |
| I | ZN408 |
| I | HOH519 |
| I | HOH526 |
| I | HOH528 |
| I | HOH547 |
| I | HOH556 |
| L | VAL279 |
| site_id | AN5 |
| Number of Residues | 7 |
| Details | binding site for residue EDO I 403 |
| Chain | Residue |
| I | GLY97 |
| I | CYS102 |
| I | ARG293 |
| I | HOH508 |
| J | GLY97 |
| J | CYS102 |
| J | ARG293 |
| site_id | AN6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO I 404 |
| Chain | Residue |
| H | THR5 |
| I | PRO245 |
| I | ILE246 |
| I | LYS249 |
| I | PHE271 |
| I | GLU272 |
| site_id | AN7 |
| Number of Residues | 2 |
| Details | binding site for residue EDO I 405 |
| Chain | Residue |
| I | GLY105 |
| J | THR104 |
| site_id | AN8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO I 406 |
| Chain | Residue |
| I | LYS189 |
| I | GLY192 |
| I | HOH509 |
| I | HOH534 |
| K | LYS189 |
| K | HOH508 |
| site_id | AN9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO I 407 |
| Chain | Residue |
| I | LEU280 |
| I | HOH537 |
| L | ALA56 |
| L | TYR118 |
| site_id | AO1 |
| Number of Residues | 6 |
| Details | binding site for residue ZN I 408 |
| Chain | Residue |
| I | CYS43 |
| I | THR45 |
| I | HIS66 |
| I | CYS152 |
| I | NAD402 |
| I | HOH531 |
| site_id | AO2 |
| Number of Residues | 5 |
| Details | binding site for residue ZN I 409 |
| Chain | Residue |
| I | CYS96 |
| I | GLY97 |
| I | CYS99 |
| I | CYS102 |
| I | CYS110 |
| site_id | AO3 |
| Number of Residues | 1 |
| Details | binding site for residue CL I 410 |
| Chain | Residue |
| I | LYS139 |
| site_id | AO4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO J 401 |
| Chain | Residue |
| J | GLU305 |
| L | GLY169 |
| L | HIS194 |
| L | HOH540 |
| site_id | AO5 |
| Number of Residues | 39 |
| Details | binding site for residue NAD J 402 |
| Chain | Residue |
| J | CYS43 |
| J | HIS44 |
| J | THR45 |
| J | HIS48 |
| J | CYS152 |
| J | THR156 |
| J | SER175 |
| J | GLY176 |
| J | ILE177 |
| J | GLY178 |
| J | GLY179 |
| J | LEU180 |
| J | ASP199 |
| J | VAL200 |
| J | LYS204 |
| J | THR241 |
| J | ALA242 |
| J | VAL243 |
| J | SER244 |
| J | ILE246 |
| J | ALA247 |
| J | ASN264 |
| J | GLY265 |
| J | LEU266 |
| J | SER288 |
| J | ILE289 |
| J | VAL290 |
| J | MET327 |
| J | ARG335 |
| J | ZN409 |
| J | HOH520 |
| J | HOH523 |
| J | HOH535 |
| J | HOH577 |
| J | HOH583 |
| J | HOH589 |
| J | HOH611 |
| J | HOH614 |
| K | VAL279 |
| site_id | AO6 |
| Number of Residues | 2 |
| Details | binding site for residue EDO J 403 |
| Chain | Residue |
| J | LYS59 |
| J | ASP121 |
| site_id | AO7 |
| Number of Residues | 2 |
| Details | binding site for residue EDO J 404 |
| Chain | Residue |
| I | GLN297 |
| J | ASP100 |
| site_id | AO8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO J 405 |
| Chain | Residue |
| J | ASN115 |
| J | TYR118 |
| J | HOH623 |
| K | LEU280 |
| site_id | AO9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO J 406 |
| Chain | Residue |
| J | LYS189 |
| J | ALA190 |
| J | GLY192 |
| L | LYS189 |
| L | ALA190 |
| L | GLY192 |
| site_id | AP1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO J 407 |
| Chain | Residue |
| J | VAL217 |
| J | ASN218 |
| J | TYR227 |
| J | HOH571 |
| J | HOH613 |
| site_id | AP2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO J 408 |
| Chain | Residue |
| J | THR104 |
| K | LYS258 |
| site_id | AP3 |
| Number of Residues | 5 |
| Details | binding site for residue ZN J 409 |
| Chain | Residue |
| J | CYS43 |
| J | HIS66 |
| J | CYS152 |
| J | NAD402 |
| J | HOH570 |
| site_id | AP4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN J 410 |
| Chain | Residue |
| J | CYS96 |
| J | CYS99 |
| J | CYS102 |
| J | CYS110 |
| site_id | AP5 |
| Number of Residues | 1 |
| Details | binding site for residue CL J 411 |
| Chain | Residue |
| J | LYS139 |
| site_id | AP6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO K 401 |
| Chain | Residue |
| I | GLY169 |
| I | HIS194 |
| I | HOH545 |
| K | ASP301 |
| K | GLU305 |
| site_id | AP7 |
| Number of Residues | 35 |
| Details | binding site for residue NAD K 402 |
| Chain | Residue |
| J | VAL279 |
| K | CYS43 |
| K | HIS44 |
| K | THR45 |
| K | HIS48 |
| K | CYS152 |
| K | THR156 |
| K | SER175 |
| K | GLY176 |
| K | ILE177 |
| K | GLY178 |
| K | GLY179 |
| K | LEU180 |
| K | ASP199 |
| K | VAL200 |
| K | LYS204 |
| K | THR241 |
| K | ALA242 |
| K | VAL243 |
| K | ALA247 |
| K | ASN264 |
| K | GLY265 |
| K | LEU266 |
| K | SER288 |
| K | ILE289 |
| K | VAL290 |
| K | ARG335 |
| K | EDO404 |
| K | ZN406 |
| K | HOH532 |
| K | HOH546 |
| K | HOH553 |
| K | HOH554 |
| K | HOH593 |
| K | HOH596 |
| site_id | AP8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO K 403 |
| Chain | Residue |
| K | ALA56 |
| K | TYR118 |
| K | HOH558 |
| site_id | AP9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO K 404 |
| Chain | Residue |
| K | ALA219 |
| K | ILE246 |
| K | GLN250 |
| K | NAD402 |
| site_id | AQ1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO K 405 |
| Chain | Residue |
| K | VAL23 |
| K | LYS59 |
| K | ASP121 |
| site_id | AQ2 |
| Number of Residues | 5 |
| Details | binding site for residue ZN K 406 |
| Chain | Residue |
| K | CYS43 |
| K | HIS66 |
| K | CYS152 |
| K | NAD402 |
| K | HOH617 |
| site_id | AQ3 |
| Number of Residues | 5 |
| Details | binding site for residue ZN K 407 |
| Chain | Residue |
| K | CYS96 |
| K | GLY97 |
| K | CYS99 |
| K | CYS102 |
| K | CYS110 |
| site_id | AQ4 |
| Number of Residues | 1 |
| Details | binding site for residue CL K 408 |
| Chain | Residue |
| K | LYS139 |
| site_id | AQ5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO L 401 |
| Chain | Residue |
| J | GLY169 |
| J | HIS194 |
| L | PHE302 |
| L | GLU305 |
| L | HOH537 |
| site_id | AQ6 |
| Number of Residues | 33 |
| Details | binding site for residue NAD L 402 |
| Chain | Residue |
| I | VAL279 |
| L | CYS43 |
| L | HIS44 |
| L | THR45 |
| L | HIS48 |
| L | CYS152 |
| L | THR156 |
| L | GLY176 |
| L | ILE177 |
| L | GLY178 |
| L | GLY179 |
| L | LEU180 |
| L | ASP199 |
| L | VAL200 |
| L | LYS204 |
| L | THR241 |
| L | ALA242 |
| L | VAL243 |
| L | SER244 |
| L | ILE246 |
| L | ALA247 |
| L | ASN264 |
| L | GLY265 |
| L | LEU266 |
| L | SER288 |
| L | ILE289 |
| L | VAL290 |
| L | ARG335 |
| L | ZN405 |
| L | HOH513 |
| L | HOH545 |
| L | HOH555 |
| L | HOH560 |
| site_id | AQ7 |
| Number of Residues | 7 |
| Details | binding site for residue EDO L 403 |
| Chain | Residue |
| K | GLY97 |
| K | CYS102 |
| K | ARG293 |
| K | HOH505 |
| L | GLY97 |
| L | CYS102 |
| L | ARG293 |
| site_id | AQ8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO L 404 |
| Chain | Residue |
| L | LYS162 |
| L | GLU163 |
| L | GLU165 |
| site_id | AQ9 |
| Number of Residues | 5 |
| Details | binding site for residue ZN L 405 |
| Chain | Residue |
| L | CYS43 |
| L | HIS66 |
| L | CYS152 |
| L | NAD402 |
| L | HOH555 |
| site_id | AR1 |
| Number of Residues | 5 |
| Details | binding site for residue ZN L 406 |
| Chain | Residue |
| L | CYS96 |
| L | GLY97 |
| L | CYS99 |
| L | CYS102 |
| L | CYS110 |
| site_id | AR2 |
| Number of Residues | 1 |
| Details | binding site for residue CL L 407 |
| Chain | Residue |
| L | LYS139 |
| site_id | AR3 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide EDO H 706 and LYS I 220 |
| Chain | Residue |
| H | VAL23 |
| H | LYS59 |
| H | PRO61 |
| H | ASP121 |
| H | VAL200 |
| H | ASN218 |
| H | ALA219 |
| H | THR221 |
| H | THR222 |
| H | EDO705 |
| I | ASN218 |
| I | ALA219 |
| I | THR221 |
| I | THR222 |
Functional Information from PROSITE/UniProt
| site_id | PS00059 |
| Number of Residues | 15 |
| Details | ADH_ZINC Zinc-containing alcohol dehydrogenases signature. GHEgVGIvvacGpdA |
| Chain | Residue | Details |
| A | GLY65-ALA79 |
