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6N7G

Cryo-EM structure of tetrameric Ptch1 in complex with ShhNp (form I)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0001658biological_processbranching involved in ureteric bud morphogenesis
A0001701biological_processin utero embryonic development
A0001709biological_processcell fate determination
A0001841biological_processneural tube formation
A0001843biological_processneural tube closure
A0003007biological_processheart morphogenesis
A0005113molecular_functionpatched binding
A0005119molecular_functionsmoothened binding
A0005515molecular_functionprotein binding
A0005794cellular_componentGolgi apparatus
A0005886cellular_componentplasma membrane
A0005901cellular_componentcaveola
A0005929cellular_componentcilium
A0007165biological_processsignal transduction
A0007224biological_processsmoothened signaling pathway
A0007286biological_processspermatid development
A0007346biological_processregulation of mitotic cell cycle
A0007389biological_processpattern specification process
A0007420biological_processbrain development
A0008158molecular_functionhedgehog receptor activity
A0008201molecular_functionheparin binding
A0008285biological_processnegative regulation of cell population proliferation
A0008544biological_processepidermis development
A0008589biological_processregulation of smoothened signaling pathway
A0009410biological_processresponse to xenobiotic stimulus
A0009612biological_processresponse to mechanical stimulus
A0009887biological_processanimal organ morphogenesis
A0009953biological_processdorsal/ventral pattern formation
A0009957biological_processepidermal cell fate specification
A0010157biological_processresponse to chlorate
A0010839biological_processnegative regulation of keratinocyte proliferation
A0010875biological_processpositive regulation of cholesterol efflux
A0014070biological_processresponse to organic cyclic compound
A0015485molecular_functioncholesterol binding
A0016020cellular_componentmembrane
A0016485biological_processprotein processing
A0021522biological_processspinal cord motor neuron differentiation
A0021532biological_processneural tube patterning
A0021904biological_processdorsal/ventral neural tube patterning
A0021997biological_processneural plate axis specification
A0030326biological_processembryonic limb morphogenesis
A0030332molecular_functioncyclin binding
A0030496cellular_componentmidbody
A0030666cellular_componentendocytic vesicle membrane
A0030850biological_processprostate gland development
A0030879biological_processmammary gland development
A0032355biological_processresponse to estradiol
A0032526biological_processresponse to retinoic acid
A0032880biological_processregulation of protein localization
A0035108biological_processlimb morphogenesis
A0035137biological_processhindlimb morphogenesis
A0040008biological_processregulation of growth
A0040015biological_processnegative regulation of multicellular organism growth
A0042127biological_processregulation of cell population proliferation
A0042593biological_processglucose homeostasis
A0043231cellular_componentintracellular membrane-bounded organelle
A0043433biological_processnegative regulation of DNA-binding transcription factor activity
A0043616biological_processkeratinocyte proliferation
A0044294cellular_componentdendritic growth cone
A0044295cellular_componentaxonal growth cone
A0044877molecular_functionprotein-containing complex binding
A0045177cellular_componentapical part of cell
A0045606biological_processpositive regulation of epidermal cell differentiation
A0045668biological_processnegative regulation of osteoblast differentiation
A0045879biological_processnegative regulation of smoothened signaling pathway
A0045892biological_processnegative regulation of DNA-templated transcription
A0045893biological_processpositive regulation of DNA-templated transcription
A0048471cellular_componentperinuclear region of cytoplasm
A0048568biological_processembryonic organ development
A0048745biological_processsmooth muscle tissue development
A0050673biological_processepithelial cell proliferation
A0050680biological_processnegative regulation of epithelial cell proliferation
A0051782biological_processnegative regulation of cell division
A0060037biological_processpharyngeal system development
A0060170cellular_componentciliary membrane
A0060603biological_processmammary gland duct morphogenesis
A0060644biological_processmammary gland epithelial cell differentiation
A0061005biological_processcell differentiation involved in kidney development
A0061053biological_processsomite development
A0071397biological_processcellular response to cholesterol
A0071679biological_processcommissural neuron axon guidance
A0072089biological_processstem cell proliferation
A0072203biological_processcell proliferation involved in metanephros development
A0072205biological_processmetanephric collecting duct development
A0072659biological_processprotein localization to plasma membrane
A0097108molecular_functionhedgehog family protein binding
A0097421biological_processliver regeneration
A2000647biological_processnegative regulation of stem cell proliferation
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0001658biological_processbranching involved in ureteric bud morphogenesis
B0001701biological_processin utero embryonic development
B0001709biological_processcell fate determination
B0001841biological_processneural tube formation
B0001843biological_processneural tube closure
B0003007biological_processheart morphogenesis
B0005113molecular_functionpatched binding
B0005119molecular_functionsmoothened binding
B0005515molecular_functionprotein binding
B0005794cellular_componentGolgi apparatus
B0005886cellular_componentplasma membrane
B0005901cellular_componentcaveola
B0005929cellular_componentcilium
B0007165biological_processsignal transduction
B0007224biological_processsmoothened signaling pathway
B0007286biological_processspermatid development
B0007346biological_processregulation of mitotic cell cycle
B0007389biological_processpattern specification process
B0007420biological_processbrain development
B0008158molecular_functionhedgehog receptor activity
B0008201molecular_functionheparin binding
B0008285biological_processnegative regulation of cell population proliferation
B0008544biological_processepidermis development
B0008589biological_processregulation of smoothened signaling pathway
B0009410biological_processresponse to xenobiotic stimulus
B0009612biological_processresponse to mechanical stimulus
B0009887biological_processanimal organ morphogenesis
B0009953biological_processdorsal/ventral pattern formation
B0009957biological_processepidermal cell fate specification
B0010157biological_processresponse to chlorate
B0010839biological_processnegative regulation of keratinocyte proliferation
B0010875biological_processpositive regulation of cholesterol efflux
B0014070biological_processresponse to organic cyclic compound
B0015485molecular_functioncholesterol binding
B0016020cellular_componentmembrane
B0016485biological_processprotein processing
B0021522biological_processspinal cord motor neuron differentiation
B0021532biological_processneural tube patterning
B0021904biological_processdorsal/ventral neural tube patterning
B0021997biological_processneural plate axis specification
B0030326biological_processembryonic limb morphogenesis
B0030332molecular_functioncyclin binding
B0030496cellular_componentmidbody
B0030666cellular_componentendocytic vesicle membrane
B0030850biological_processprostate gland development
B0030879biological_processmammary gland development
B0032355biological_processresponse to estradiol
B0032526biological_processresponse to retinoic acid
B0032880biological_processregulation of protein localization
B0035108biological_processlimb morphogenesis
B0035137biological_processhindlimb morphogenesis
B0040008biological_processregulation of growth
B0040015biological_processnegative regulation of multicellular organism growth
B0042127biological_processregulation of cell population proliferation
B0042593biological_processglucose homeostasis
B0043231cellular_componentintracellular membrane-bounded organelle
B0043433biological_processnegative regulation of DNA-binding transcription factor activity
B0043616biological_processkeratinocyte proliferation
B0044294cellular_componentdendritic growth cone
B0044295cellular_componentaxonal growth cone
B0044877molecular_functionprotein-containing complex binding
B0045177cellular_componentapical part of cell
B0045606biological_processpositive regulation of epidermal cell differentiation
B0045668biological_processnegative regulation of osteoblast differentiation
B0045879biological_processnegative regulation of smoothened signaling pathway
B0045892biological_processnegative regulation of DNA-templated transcription
B0045893biological_processpositive regulation of DNA-templated transcription
B0048471cellular_componentperinuclear region of cytoplasm
B0048568biological_processembryonic organ development
B0048745biological_processsmooth muscle tissue development
B0050673biological_processepithelial cell proliferation
B0050680biological_processnegative regulation of epithelial cell proliferation
B0051782biological_processnegative regulation of cell division
B0060037biological_processpharyngeal system development
B0060170cellular_componentciliary membrane
B0060603biological_processmammary gland duct morphogenesis
B0060644biological_processmammary gland epithelial cell differentiation
B0061005biological_processcell differentiation involved in kidney development
B0061053biological_processsomite development
B0071397biological_processcellular response to cholesterol
B0071679biological_processcommissural neuron axon guidance
B0072089biological_processstem cell proliferation
B0072203biological_processcell proliferation involved in metanephros development
B0072205biological_processmetanephric collecting duct development
B0072659biological_processprotein localization to plasma membrane
B0097108molecular_functionhedgehog family protein binding
B0097421biological_processliver regeneration
B2000647biological_processnegative regulation of stem cell proliferation
C0007267biological_processcell-cell signaling
C0007275biological_processmulticellular organism development
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0001658biological_processbranching involved in ureteric bud morphogenesis
D0001701biological_processin utero embryonic development
D0001709biological_processcell fate determination
D0001841biological_processneural tube formation
D0001843biological_processneural tube closure
D0003007biological_processheart morphogenesis
D0005113molecular_functionpatched binding
D0005119molecular_functionsmoothened binding
D0005515molecular_functionprotein binding
D0005794cellular_componentGolgi apparatus
D0005886cellular_componentplasma membrane
D0005901cellular_componentcaveola
D0005929cellular_componentcilium
D0007165biological_processsignal transduction
D0007224biological_processsmoothened signaling pathway
D0007286biological_processspermatid development
D0007346biological_processregulation of mitotic cell cycle
D0007389biological_processpattern specification process
D0007420biological_processbrain development
D0008158molecular_functionhedgehog receptor activity
D0008201molecular_functionheparin binding
D0008285biological_processnegative regulation of cell population proliferation
D0008544biological_processepidermis development
D0008589biological_processregulation of smoothened signaling pathway
D0009410biological_processresponse to xenobiotic stimulus
D0009612biological_processresponse to mechanical stimulus
D0009887biological_processanimal organ morphogenesis
D0009953biological_processdorsal/ventral pattern formation
D0009957biological_processepidermal cell fate specification
D0010157biological_processresponse to chlorate
D0010839biological_processnegative regulation of keratinocyte proliferation
D0010875biological_processpositive regulation of cholesterol efflux
D0014070biological_processresponse to organic cyclic compound
D0015485molecular_functioncholesterol binding
D0016020cellular_componentmembrane
D0016485biological_processprotein processing
D0021522biological_processspinal cord motor neuron differentiation
D0021532biological_processneural tube patterning
D0021904biological_processdorsal/ventral neural tube patterning
D0021997biological_processneural plate axis specification
D0030326biological_processembryonic limb morphogenesis
D0030332molecular_functioncyclin binding
D0030496cellular_componentmidbody
D0030666cellular_componentendocytic vesicle membrane
D0030850biological_processprostate gland development
D0030879biological_processmammary gland development
D0032355biological_processresponse to estradiol
D0032526biological_processresponse to retinoic acid
D0032880biological_processregulation of protein localization
D0035108biological_processlimb morphogenesis
D0035137biological_processhindlimb morphogenesis
D0040008biological_processregulation of growth
D0040015biological_processnegative regulation of multicellular organism growth
D0042127biological_processregulation of cell population proliferation
D0042593biological_processglucose homeostasis
D0043231cellular_componentintracellular membrane-bounded organelle
D0043433biological_processnegative regulation of DNA-binding transcription factor activity
D0043616biological_processkeratinocyte proliferation
D0044294cellular_componentdendritic growth cone
D0044295cellular_componentaxonal growth cone
D0044877molecular_functionprotein-containing complex binding
D0045177cellular_componentapical part of cell
D0045606biological_processpositive regulation of epidermal cell differentiation
D0045668biological_processnegative regulation of osteoblast differentiation
D0045879biological_processnegative regulation of smoothened signaling pathway
D0045892biological_processnegative regulation of DNA-templated transcription
D0045893biological_processpositive regulation of DNA-templated transcription
D0048471cellular_componentperinuclear region of cytoplasm
D0048568biological_processembryonic organ development
D0048745biological_processsmooth muscle tissue development
D0050673biological_processepithelial cell proliferation
D0050680biological_processnegative regulation of epithelial cell proliferation
D0051782biological_processnegative regulation of cell division
D0060037biological_processpharyngeal system development
D0060170cellular_componentciliary membrane
D0060603biological_processmammary gland duct morphogenesis
D0060644biological_processmammary gland epithelial cell differentiation
D0061005biological_processcell differentiation involved in kidney development
D0061053biological_processsomite development
D0071397biological_processcellular response to cholesterol
D0071679biological_processcommissural neuron axon guidance
D0072089biological_processstem cell proliferation
D0072203biological_processcell proliferation involved in metanephros development
D0072205biological_processmetanephric collecting duct development
D0072659biological_processprotein localization to plasma membrane
D0097108molecular_functionhedgehog family protein binding
D0097421biological_processliver regeneration
D2000647biological_processnegative regulation of stem cell proliferation
E0000122biological_processnegative regulation of transcription by RNA polymerase II
E0001658biological_processbranching involved in ureteric bud morphogenesis
E0001701biological_processin utero embryonic development
E0001709biological_processcell fate determination
E0001841biological_processneural tube formation
E0001843biological_processneural tube closure
E0003007biological_processheart morphogenesis
E0005113molecular_functionpatched binding
E0005119molecular_functionsmoothened binding
E0005515molecular_functionprotein binding
E0005794cellular_componentGolgi apparatus
E0005886cellular_componentplasma membrane
E0005901cellular_componentcaveola
E0005929cellular_componentcilium
E0007165biological_processsignal transduction
E0007224biological_processsmoothened signaling pathway
E0007286biological_processspermatid development
E0007346biological_processregulation of mitotic cell cycle
E0007389biological_processpattern specification process
E0007420biological_processbrain development
E0008158molecular_functionhedgehog receptor activity
E0008201molecular_functionheparin binding
E0008285biological_processnegative regulation of cell population proliferation
E0008544biological_processepidermis development
E0008589biological_processregulation of smoothened signaling pathway
E0009410biological_processresponse to xenobiotic stimulus
E0009612biological_processresponse to mechanical stimulus
E0009887biological_processanimal organ morphogenesis
E0009953biological_processdorsal/ventral pattern formation
E0009957biological_processepidermal cell fate specification
E0010157biological_processresponse to chlorate
E0010839biological_processnegative regulation of keratinocyte proliferation
E0010875biological_processpositive regulation of cholesterol efflux
E0014070biological_processresponse to organic cyclic compound
E0015485molecular_functioncholesterol binding
E0016020cellular_componentmembrane
E0016485biological_processprotein processing
E0021522biological_processspinal cord motor neuron differentiation
E0021532biological_processneural tube patterning
E0021904biological_processdorsal/ventral neural tube patterning
E0021997biological_processneural plate axis specification
E0030326biological_processembryonic limb morphogenesis
E0030332molecular_functioncyclin binding
E0030496cellular_componentmidbody
E0030666cellular_componentendocytic vesicle membrane
E0030850biological_processprostate gland development
E0030879biological_processmammary gland development
E0032355biological_processresponse to estradiol
E0032526biological_processresponse to retinoic acid
E0032880biological_processregulation of protein localization
E0035108biological_processlimb morphogenesis
E0035137biological_processhindlimb morphogenesis
E0040008biological_processregulation of growth
E0040015biological_processnegative regulation of multicellular organism growth
E0042127biological_processregulation of cell population proliferation
E0042593biological_processglucose homeostasis
E0043231cellular_componentintracellular membrane-bounded organelle
E0043433biological_processnegative regulation of DNA-binding transcription factor activity
E0043616biological_processkeratinocyte proliferation
E0044294cellular_componentdendritic growth cone
E0044295cellular_componentaxonal growth cone
E0044877molecular_functionprotein-containing complex binding
E0045177cellular_componentapical part of cell
E0045606biological_processpositive regulation of epidermal cell differentiation
E0045668biological_processnegative regulation of osteoblast differentiation
E0045879biological_processnegative regulation of smoothened signaling pathway
E0045892biological_processnegative regulation of DNA-templated transcription
E0045893biological_processpositive regulation of DNA-templated transcription
E0048471cellular_componentperinuclear region of cytoplasm
E0048568biological_processembryonic organ development
E0048745biological_processsmooth muscle tissue development
E0050673biological_processepithelial cell proliferation
E0050680biological_processnegative regulation of epithelial cell proliferation
E0051782biological_processnegative regulation of cell division
E0060037biological_processpharyngeal system development
E0060170cellular_componentciliary membrane
E0060603biological_processmammary gland duct morphogenesis
E0060644biological_processmammary gland epithelial cell differentiation
E0061005biological_processcell differentiation involved in kidney development
E0061053biological_processsomite development
E0071397biological_processcellular response to cholesterol
E0071679biological_processcommissural neuron axon guidance
E0072089biological_processstem cell proliferation
E0072203biological_processcell proliferation involved in metanephros development
E0072205biological_processmetanephric collecting duct development
E0072659biological_processprotein localization to plasma membrane
E0097108molecular_functionhedgehog family protein binding
E0097421biological_processliver regeneration
E2000647biological_processnegative regulation of stem cell proliferation
F0007267biological_processcell-cell signaling
F0007275biological_processmulticellular organism development
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues14
DetailsBINDING: BINDING => ECO:0000269|PubMed:20504762, ECO:0007744|PDB:3MXW
ChainResidueDetails
CGLU89
FASP95
FTHR125
FGLU126
FASP129
FASP131
DSER523-SER547
DASP599-LYS748
DASN1049-ILE1055
DLEU1105-HIS1121
EMET1-LYS100
CGLU90
ELEU458-ALA472
ESER523-SER547
EASP599-LYS748
EASN1049-ILE1055
ELEU1105-HIS1121
CASP95
CTHR125
CGLU126
CASP129
CASP131
FGLU89
FGLU90

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:10753901, ECO:0000269|PubMed:20504762, ECO:0007744|PDB:3M1N, ECO:0007744|PDB:3MXW
ChainResidueDetails
CHIS140
AVAL1084-PHE1104
AMET1122-ALA1141
AVAL1155-LEU1175
BPHE101-LEU121
BVAL437-MET457
BGLY473-ILE493
BVAL502-PHE522
BVAL548-PRO568
BALA578-MET598
BALA749-THR769
CASP147
BLEU1028-LEU1048
BILE1056-ILE1076
BVAL1084-PHE1104
BMET1122-ALA1141
BVAL1155-LEU1175
DPHE101-LEU121
DVAL437-MET457
DGLY473-ILE493
DVAL502-PHE522
DVAL548-PRO568
CHIS182
DALA578-MET598
DALA749-THR769
DLEU1028-LEU1048
DILE1056-ILE1076
DVAL1084-PHE1104
DMET1122-ALA1141
DVAL1155-LEU1175
EPHE101-LEU121
EVAL437-MET457
EGLY473-ILE493
FHIS140
EVAL502-PHE522
EVAL548-PRO568
EALA578-MET598
EALA749-THR769
ELEU1028-LEU1048
EILE1056-ILE1076
EVAL1084-PHE1104
EMET1122-ALA1141
EVAL1155-LEU1175
FASP147
FHIS182
AALA749-THR769
ALEU1028-LEU1048
AILE1056-ILE1076

site_idSWS_FT_FI3
Number of Residues2
DetailsSITE: Cleavage; by autolysis => ECO:0000250|UniProtKB:Q02936
ChainResidueDetails
CGLY197
BARG770-TRP1027
BLYS1077-VAL1083
BGLY1142-ALA1154
DGLU122-ASP436
DSER494-GLN501
DALA569-ALA577
DARG770-TRP1027
DLYS1077-VAL1083
DGLY1142-ALA1154
EGLU122-ASP436
FGLY197
ESER494-GLN501
EALA569-ALA577
EARG770-TRP1027
ELYS1077-VAL1083
EGLY1142-ALA1154
AALA569-ALA577
AARG770-TRP1027
ALYS1077-VAL1083
AGLY1142-ALA1154
BGLU122-ASP436
BSER494-GLN501
BALA569-ALA577

site_idSWS_FT_FI4
Number of Residues2
DetailsLIPID: N-palmitoyl cysteine => ECO:0000269|PubMed:18534984, ECO:0000269|PubMed:31875564, ECO:0000269|PubMed:9593755
ChainResidueDetails
CCYS24
FCYS24
DTHR1195
ETHR1195

site_idSWS_FT_FI5
Number of Residues2
DetailsLIPID: Cholesterol glycine ester => ECO:0000250|UniProtKB:Q62226
ChainResidueDetails
CGLY197
FGLY197
DSER1197
ESER1197

site_idSWS_FT_FI6
Number of Residues24
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN141
BASN414
BASN875
BASN1000
DASN141
DASN312
DASN349
DASN414
DASN875
DASN1000
EASN141
AASN312
EASN312
EASN349
EASN414
EASN875
EASN1000
AASN349
AASN414
AASN875
AASN1000
BASN141
BASN312
BASN349

223166

PDB entries from 2024-07-31

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