6N6T

OXA-23 mutant F110A/M221A low pH form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0008658	molecular_function	penicillin binding
A	0016787	molecular_function	hydrolase activity
A	0042597	cellular_component	periplasmic space
A	0046677	biological_process	response to antibiotic
A	0071555	biological_process	cell wall organization

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue FLC A 301

Chain	Residue
A	ALA78
A	HOH414
A	HOH424
A	HOH470
A	HOH495
A	HOH570
A	HOH575
A	SER79
A	SER126
A	ALA127
A	LEU166
A	THR217
A	GLY218
A	TRP219
A	ARG259

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Acyl-ester intermediate => ECO:0000269|PubMed:24012371, ECO:0000269|PubMed:30530607, ECO:0000312|PDB:6N6U, ECO:0007744|PDB:4JF4, ECO:0007744|PDB:6N6V

Chain	Residue	Details
A	SER79

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:24012371, ECO:0000269|PubMed:30530607, ECO:0000312|PDB:6N6U, ECO:0007744|PDB:4JF4, ECO:0007744|PDB:6N6V

Chain	Residue	Details
A	SER79
A	THR217
A	TRP219
A	ARG259

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P13661

Chain	Residue	Details
A	LYS82
A	SER126

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-carboxylysine => ECO:0000269|PubMed:24012371, ECO:0000269|PubMed:30530607, ECO:0000269|PubMed:35420470, ECO:0007744|PDB:4JF5, ECO:0007744|PDB:4JF6, ECO:0007744|PDB:6N6T, ECO:0007744|PDB:6N6W, ECO:0007744|PDB:7T7G

Chain	Residue	Details
A	LYS82

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