6N6K

Human REXO2 bound to pAG

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000175	molecular_function	3'-5'-RNA exonuclease activity
A	0003676	molecular_function	nucleic acid binding
B	0000175	molecular_function	3'-5'-RNA exonuclease activity
B	0003676	molecular_function	nucleic acid binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue MLI A 301

Chain	Residue
A	LYS186
A	ILE187
B	ARG97
B	PRO102
B	GLU151

---

site_id	AC2
Number of Residues	6
Details	binding site for residue NA D 701

Chain	Residue
D	A603
D	G604
A	ASP15
A	HOH432
A	HOH507
A	HOH589

---

site_id	AC3
Number of Residues	6
Details	binding site for residue NA C 701

Chain	Residue
B	ASP15
B	HOH326
B	HOH398
B	HOH471
C	A603
C	G604

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	328
Details	Domain: {"description":"Exonuclease"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PubMed","id":"30926754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31588022","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30926754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31588022","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J7Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RCN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30926754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31588022","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RCN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30926754","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J7Y","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	Site: {"description":"Important for dinucleotide binding","evidences":[{"source":"PubMed","id":"30926754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32365187","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9D8S4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---