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6N6K

Human REXO2 bound to pAG

Functional Information from GO Data
ChainGOidnamespacecontents
A0000175molecular_function3'-5'-RNA exonuclease activity
A0003676molecular_functionnucleic acid binding
B0000175molecular_function3'-5'-RNA exonuclease activity
B0003676molecular_functionnucleic acid binding
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue MLI A 301
ChainResidue
ALYS186
AILE187
BARG97
BPRO102
BGLU151

site_idAC2
Number of Residues6
Detailsbinding site for residue NA D 701
ChainResidue
DA603
DG604
AASP15
AHOH432
AHOH507
AHOH589

site_idAC3
Number of Residues6
Detailsbinding site for residue NA C 701
ChainResidue
BASP15
BHOH326
BHOH398
BHOH471
CA603
CG604

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: ACT_SITE => ECO:0000269|PubMed:30926754, ECO:0000269|PubMed:31588022
ChainResidueDetails
AILE194
BILE194

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:30926754, ECO:0000269|PubMed:31588022, ECO:0007744|PDB:6J7Y, ECO:0007744|PDB:6RCN
ChainResidueDetails
APRO47
ALEU49
BPRO47
BLEU49

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:30926754, ECO:0000269|PubMed:31588022, ECO:0007744|PDB:6RCN
ChainResidueDetails
ATRP147
BTRP147

site_idSWS_FT_FI4
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:30926754, ECO:0007744|PDB:6J7Y
ChainResidueDetails
AGLU199
BGLU199

site_idSWS_FT_FI5
Number of Residues6
DetailsSITE: Important for dinucleotide binding => ECO:0000269|PubMed:30926754, ECO:0000269|PubMed:32365187
ChainResidueDetails
AGLN53
AVAL96
AALA164
BGLN53
BVAL96
BALA164

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
APHE92
BPHE92

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455
ChainResidueDetails
ATYR122
BTYR122

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9D8S4
ChainResidueDetails
ALYS173
BLYS173

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PDB entries from 2024-07-24

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