6N4E

hPGDS complexed with a quinoline-3-carboxamide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0001516	biological_process	prostaglandin biosynthetic process
A	0004364	molecular_function	glutathione transferase activity
A	0004667	molecular_function	prostaglandin-D synthase activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006693	biological_process	prostaglandin metabolic process
A	0007165	biological_process	signal transduction
A	0007626	biological_process	locomotory behavior
A	0016740	molecular_function	transferase activity
A	0016853	molecular_function	isomerase activity
A	0042803	molecular_function	protein homodimerization activity
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0046872	molecular_function	metal ion binding
A	2000255	biological_process	negative regulation of male germ cell proliferation

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue GSH A 201

Chain	Residue
A	TYR8
A	HOH356
A	HOH382
A	ARG14
A	TRP39
A	LYS43
A	LYS50
A	ILE51
A	GLN63
A	SER64
A	ASP97

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site_id	AC2
Number of Residues	12
Details	binding site for residue KCD A 202

Chain	Residue
A	PHE9
A	GLY13
A	ARG14
A	GLN36
A	MET99
A	TRP104
A	TYR152
A	ILE155
A	CYS156
A	LEU199
A	HOH313
A	HOH319

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518

Chain	Residue	Details
A	TYR8
A	ARG14
A	TRP39
A	GLY49
A	GLN63

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