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6N3L

Identification of novel, potent and selective GCN2 inhibitors as first-in-class anti-tumor agents

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
B0004672molecular_functionprotein kinase activity
B0005524molecular_functionATP binding
B0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues19
Detailsbinding site for residue KAV A 2501
ChainResidue
ALEU596
ATYR804
ACYS805
AALA807
AMET844
AHIS846
APHE855
AILE864
AGLY865
AASP866
APHE867
AVAL604
AALA617
ALYS619
AGLU636
ALEU640
ALEU643
AMET802
AGLU803

site_idAC2
Number of Residues21
Detailsbinding site for residue KAV B 2501
ChainResidue
BLEU596
BVAL604
BALA617
BLYS619
BGLU636
BLEU640
BLEU643
BILE648
BVAL649
BMET802
BGLU803
BTYR804
BCYS805
BILE839
BMET844
BHIS846
BPHE855
BILE864
BGLY865
BASP866
BPHE867

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGAFGAVIkVqnkldgcc..........YAVK
ChainResidueDetails
ALEU596-LYS619

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
ChainResidueDetails
AASN848
BASN848

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
ALEU596
ALYS619
BLEU596
BLYS619

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ATHR871
BTHR871

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by autocatalysis => ECO:0000250|UniProtKB:Q9QZ05
ChainResidueDetails
AALA899
BALA899

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by autocatalysis => ECO:0000250
ChainResidueDetails
AALA904
BALA904

218853

PDB entries from 2024-04-24

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