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6N1K

Full-length human phenylalanine hydroxylase (PAH) in the resting state

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
A0004497molecular_functionmonooxygenase activity
A0004505molecular_functionphenylalanine 4-monooxygenase activity
A0005506molecular_functioniron ion binding
A0005829cellular_componentcytosol
A0006559biological_processL-phenylalanine catabolic process
A0006571biological_processtyrosine biosynthetic process
A0008152biological_processmetabolic process
A0008652biological_processamino acid biosynthetic process
A0009072biological_processaromatic amino acid metabolic process
A0016491molecular_functionoxidoreductase activity
A0016714molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
A0019293biological_processtyrosine biosynthetic process, by oxidation of phenylalanine
A0042423biological_processcatecholamine biosynthetic process
A0046872molecular_functionmetal ion binding
B0003824molecular_functioncatalytic activity
B0004497molecular_functionmonooxygenase activity
B0004505molecular_functionphenylalanine 4-monooxygenase activity
B0005506molecular_functioniron ion binding
B0005829cellular_componentcytosol
B0006559biological_processL-phenylalanine catabolic process
B0006571biological_processtyrosine biosynthetic process
B0008152biological_processmetabolic process
B0008652biological_processamino acid biosynthetic process
B0009072biological_processaromatic amino acid metabolic process
B0016491molecular_functionoxidoreductase activity
B0016714molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
B0019293biological_processtyrosine biosynthetic process, by oxidation of phenylalanine
B0042423biological_processcatecholamine biosynthetic process
B0046872molecular_functionmetal ion binding
C0003824molecular_functioncatalytic activity
C0004497molecular_functionmonooxygenase activity
C0004505molecular_functionphenylalanine 4-monooxygenase activity
C0005506molecular_functioniron ion binding
C0005829cellular_componentcytosol
C0006559biological_processL-phenylalanine catabolic process
C0006571biological_processtyrosine biosynthetic process
C0008152biological_processmetabolic process
C0008652biological_processamino acid biosynthetic process
C0009072biological_processaromatic amino acid metabolic process
C0016491molecular_functionoxidoreductase activity
C0016714molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
C0019293biological_processtyrosine biosynthetic process, by oxidation of phenylalanine
C0042423biological_processcatecholamine biosynthetic process
C0046872molecular_functionmetal ion binding
D0003824molecular_functioncatalytic activity
D0004497molecular_functionmonooxygenase activity
D0004505molecular_functionphenylalanine 4-monooxygenase activity
D0005506molecular_functioniron ion binding
D0005829cellular_componentcytosol
D0006559biological_processL-phenylalanine catabolic process
D0006571biological_processtyrosine biosynthetic process
D0008152biological_processmetabolic process
D0008652biological_processamino acid biosynthetic process
D0009072biological_processaromatic amino acid metabolic process
D0016491molecular_functionoxidoreductase activity
D0016714molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
D0019293biological_processtyrosine biosynthetic process, by oxidation of phenylalanine
D0042423biological_processcatecholamine biosynthetic process
D0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues1
Detailsbinding site for residue CL A 501
ChainResidue
AARG297

site_idAC2
Number of Residues5
Detailsbinding site for residue FE A 502
ChainResidue
AHIS285
AHIS290
AGLU330
AHOH601
AHOH602

site_idAC3
Number of Residues2
Detailsbinding site for residue CL B 501
ChainResidue
AARG71
BARG297

site_idAC4
Number of Residues5
Detailsbinding site for residue FE B 502
ChainResidue
BHIS290
BGLU330
BHOH601
BHOH602
BHIS285

site_idAC5
Number of Residues4
Detailsbinding site for residue CL C 501
ChainResidue
CARG261
CARG297
CGLN301
DTYR417

site_idAC6
Number of Residues4
Detailsbinding site for residue FE C 502
ChainResidue
CHIS285
CHIS290
CGLU330
CHOH601

site_idAC7
Number of Residues2
Detailsbinding site for residue CL D 501
ChainResidue
DARG297
DGLN301

site_idAC8
Number of Residues5
Detailsbinding site for residue FE D 502
ChainResidue
DHIS285
DHIS290
DGLU330
DHOH601
DHOH602

Functional Information from PROSITE/UniProt
site_idPS00367
Number of Residues12
DetailsBH4_AAA_HYDROXYL_1 Biopterin-dependent aromatic amino acid hydroxylases signature. PDicHELLGHVP
ChainResidueDetails
APRO281-PRO292

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P04176
ChainResidueDetails
AHIS285
DHIS285
DHIS290
DGLU330
AHIS290
AGLU330
BHIS285
BHIS290
BGLU330
CHIS285
CHIS290
CGLU330

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:12185072, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER16
BSER16
CSER16
DSER16

218853

PDB entries from 2024-04-24

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