6N13
UbcH7-Ub Complex with R0RBR Parkin and phosphoubiquitin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016567 | biological_process | protein ubiquitination |
| C | 0000151 | cellular_component | ubiquitin ligase complex |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0000209 | biological_process | protein polyubiquitination |
| C | 0003713 | molecular_function | transcription coactivator activity |
| C | 0003723 | molecular_function | RNA binding |
| C | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| C | 0008283 | biological_process | cell population proliferation |
| C | 0016567 | biological_process | protein ubiquitination |
| C | 0016740 | molecular_function | transferase activity |
| C | 0019787 | molecular_function | ubiquitin-like protein transferase activity |
| C | 0019899 | molecular_function | enzyme binding |
| C | 0031398 | biological_process | positive regulation of protein ubiquitination |
| C | 0031625 | molecular_function | ubiquitin protein ligase binding |
| C | 0032446 | biological_process | protein modification by small protein conjugation |
| C | 0036211 | biological_process | protein modification process |
| C | 0044770 | biological_process | cell cycle phase transition |
| C | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| C | 0061631 | molecular_function | ubiquitin conjugating enzyme activity |
| C | 0070979 | biological_process | protein K11-linked ubiquitination |
| C | 0071383 | biological_process | cellular response to steroid hormone stimulus |
| C | 0071385 | biological_process | cellular response to glucocorticoid stimulus |
| C | 0097027 | molecular_function | ubiquitin-protein transferase activator activity |
| C | 1903955 | biological_process | positive regulation of protein targeting to mitochondrion |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 501 |
| Chain | Residue |
| B | CYS253 |
| B | HIS257 |
| B | CYS289 |
| B | CYS293 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue ZN B 502 |
| Chain | Residue |
| B | GLU370 |
| B | HIS373 |
| B | CYS377 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue ZN B 503 |
| Chain | Residue |
| B | CYS449 |
| B | CYS457 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 504 |
| Chain | Residue |
| B | CYS166 |
| B | CYS169 |
| B | CYS196 |
| B | CYS201 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 505 |
| Chain | Residue |
| B | CYS238 |
| B | CYS241 |
| B | CYS260 |
| B | CYS263 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 506 |
| Chain | Residue |
| B | CYS337 |
| B | CYS352 |
| B | LEU358 |
| B | GLY359 |
| B | CYS360 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 507 |
| Chain | Residue |
| B | CYS418 |
| B | ARG420 |
| B | CYS421 |
| B | CYS436 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 508 |
| Chain | Residue |
| B | CYS150 |
| B | CYS154 |
| B | CYS212 |
| B | HIS215 |
Functional Information from PROSITE/UniProt
| site_id | PS00299 |
| Number of Residues | 26 |
| Details | UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD |
| Chain | Residue | Details |
| A | LYS27-ASP52 | |
| D | LYS727-ASP752 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | SITE: Interacts with activating enzyme |
| Chain | Residue | Details |
| D | ARG754 | |
| D | ARG772 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | SITE: Essential for function |
| Chain | Residue | Details |
| D | HIS768 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291 |
| Chain | Residue | Details |
| D | SER765 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457 |
| Chain | Residue | Details |
| D | THR766 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: ADP-ribosylglycine => ECO:0000269|PubMed:28525742 |
| Chain | Residue | Details |
| D | GLY776 | |
| B | CYS449 | |
| B | CYS457 | |
| B | HIS461 | |
| B | CYS241 | |
| B | CYS253 | |
| B | HIS257 | |
| B | CYS260 | |
| B | CYS263 | |
| B | CYS289 | |
| B | CYS293 | |
| B | HIS373 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 |
| Chain | Residue | Details |
| D | LYS706 | |
| B | CYS436 | |
| B | CYS441 | |
| B | CYS446 | |
| B | CYS337 | |
| B | CYS352 | |
| B | CYS360 | |
| B | CYS365 | |
| B | CYS368 | |
| B | CYS377 | |
| B | CYS418 | |
| B | CYS421 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) |
| Chain | Residue | Details |
| B | THR175 | |
| D | GLY776 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 |
| Chain | Residue | Details |
| D | LYS711 | |
| D | LYS748 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 |
| Chain | Residue | Details |
| D | LYS727 | |
| B | LYS369 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 |
| Chain | Residue | Details |
| D | LYS729 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 |
| Chain | Residue | Details |
| D | LYS733 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 |
| Chain | Residue | Details |
| D | LYS763 |
Catalytic Information from CSA
