6N0Y

Crystal structure of Anaerolinea thermophila mevalonate 5-phosphate decarboxylase complexed with (R)-MVAPP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004163	molecular_function	diphosphomevalonate decarboxylase activity
A	0005829	cellular_component	cytosol
A	0008299	biological_process	isoprenoid biosynthetic process
A	0016831	molecular_function	carboxy-lyase activity
A	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
B	0004163	molecular_function	diphosphomevalonate decarboxylase activity
B	0005829	cellular_component	cytosol
B	0008299	biological_process	isoprenoid biosynthetic process
B	0016831	molecular_function	carboxy-lyase activity
B	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
C	0004163	molecular_function	diphosphomevalonate decarboxylase activity
C	0005829	cellular_component	cytosol
C	0008299	biological_process	isoprenoid biosynthetic process
C	0016831	molecular_function	carboxy-lyase activity
C	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
D	0004163	molecular_function	diphosphomevalonate decarboxylase activity
D	0005829	cellular_component	cytosol
D	0008299	biological_process	isoprenoid biosynthetic process
D	0016831	molecular_function	carboxy-lyase activity
D	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
E	0004163	molecular_function	diphosphomevalonate decarboxylase activity
E	0005829	cellular_component	cytosol
E	0008299	biological_process	isoprenoid biosynthetic process
E	0016831	molecular_function	carboxy-lyase activity
E	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
F	0004163	molecular_function	diphosphomevalonate decarboxylase activity
F	0005829	cellular_component	cytosol
F	0008299	biological_process	isoprenoid biosynthetic process
F	0016831	molecular_function	carboxy-lyase activity
F	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue DP6 A 401

Chain	Residue
A	ALA13
A	ARG143
A	SER190
A	THR191
A	HIS194
A	ASP280
A	ALA281
A	HOH555
A	HOH592
A	HOH615
A	LYS16
A	TYR17
A	ARG26
A	ARG71
A	SER106
A	SER138
A	GLY139
A	SER140

---

site_id	AC2
Number of Residues	17
Details	binding site for residue DP6 B 401

Chain	Residue
B	ALA13
B	TYR17
B	ARG26
B	ARG71
B	ALA104
B	SER106
B	SER138
B	GLY139
B	SER140
B	ARG143
B	SER190
B	THR191
B	HIS194
B	ASP280
B	ALA281
B	HOH521
B	HOH611

---

site_id	AC3
Number of Residues	18
Details	binding site for residue DP6 C 401

Chain	Residue
C	ALA13
C	LYS16
C	TYR17
C	ARG26
C	ARG71
C	ALA104
C	SER106
C	SER138
C	GLY139
C	SER140
C	ARG143
C	SER190
C	THR191
C	HIS194
C	ASP280
C	ALA281
C	HOH528
C	HOH608

---

site_id	AC4
Number of Residues	21
Details	binding site for residue DP6 D 401

Chain	Residue
D	ALA13
D	LYS16
D	TYR17
D	ARG26
D	ARG71
D	ALA104
D	SER106
D	SER138
D	GLY139
D	SER140
D	ARG143
D	SER190
D	THR191
D	HIS194
D	ASP280
D	ALA281
D	HOH502
D	HOH527
D	HOH566
D	HOH583
D	HOH596

---

site_id	AC5
Number of Residues	17
Details	binding site for residue DP6 E 401

Chain	Residue
E	ALA13
E	LYS16
E	TYR17
E	ARG26
E	ARG71
E	SER106
E	SER138
E	GLY139
E	SER140
E	ARG143
E	SER190
E	THR191
E	HIS194
E	ASP280
E	ALA281
E	HOH509
E	HOH558

---

site_id	AC6
Number of Residues	16
Details	binding site for residue DP6 F 401

Chain	Residue
F	SER140
F	ARG143
F	SER190
F	THR191
F	HIS194
F	ASP280
F	HOH536
F	HOH575
F	ALA13
F	LYS16
F	TYR17
F	ARG26
F	ARG71
F	SER106
F	SER138
F	GLY139

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