Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6N0X

Crystal structure of Anaerolinea thermophila mevalonate 5-phosphate decarboxylase complexed with (R)-MVAP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004163	molecular_function	diphosphomevalonate decarboxylase activity
A	0005524	molecular_function	ATP binding
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0008299	biological_process	isoprenoid biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation
A	0016829	molecular_function	lyase activity
A	0016831	molecular_function	carboxy-lyase activity
A	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
B	0000166	molecular_function	nucleotide binding
B	0004163	molecular_function	diphosphomevalonate decarboxylase activity
B	0005524	molecular_function	ATP binding
B	0005829	cellular_component	cytosol
B	0006629	biological_process	lipid metabolic process
B	0008299	biological_process	isoprenoid biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016310	biological_process	phosphorylation
B	0016829	molecular_function	lyase activity
B	0016831	molecular_function	carboxy-lyase activity
B	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
C	0000166	molecular_function	nucleotide binding
C	0004163	molecular_function	diphosphomevalonate decarboxylase activity
C	0005524	molecular_function	ATP binding
C	0005829	cellular_component	cytosol
C	0006629	biological_process	lipid metabolic process
C	0008299	biological_process	isoprenoid biosynthetic process
C	0016301	molecular_function	kinase activity
C	0016310	biological_process	phosphorylation
C	0016829	molecular_function	lyase activity
C	0016831	molecular_function	carboxy-lyase activity
C	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
D	0000166	molecular_function	nucleotide binding
D	0004163	molecular_function	diphosphomevalonate decarboxylase activity
D	0005524	molecular_function	ATP binding
D	0005829	cellular_component	cytosol
D	0006629	biological_process	lipid metabolic process
D	0008299	biological_process	isoprenoid biosynthetic process
D	0016301	molecular_function	kinase activity
D	0016310	biological_process	phosphorylation
D	0016829	molecular_function	lyase activity
D	0016831	molecular_function	carboxy-lyase activity
D	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
E	0000166	molecular_function	nucleotide binding
E	0004163	molecular_function	diphosphomevalonate decarboxylase activity
E	0005524	molecular_function	ATP binding
E	0005829	cellular_component	cytosol
E	0006629	biological_process	lipid metabolic process
E	0008299	biological_process	isoprenoid biosynthetic process
E	0016301	molecular_function	kinase activity
E	0016310	biological_process	phosphorylation
E	0016829	molecular_function	lyase activity
E	0016831	molecular_function	carboxy-lyase activity
E	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
F	0000166	molecular_function	nucleotide binding
F	0004163	molecular_function	diphosphomevalonate decarboxylase activity
F	0005524	molecular_function	ATP binding
F	0005829	cellular_component	cytosol
F	0006629	biological_process	lipid metabolic process
F	0008299	biological_process	isoprenoid biosynthetic process
F	0016301	molecular_function	kinase activity
F	0016310	biological_process	phosphorylation
F	0016829	molecular_function	lyase activity
F	0016831	molecular_function	carboxy-lyase activity
F	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue PMV A 1001

Chain	Residue
A	ALA13
A	ASP280
A	HOH1112
A	HOH1126
A	HOH1130
A	HOH1202
A	HOH1294
A	LYS16
A	TYR17
A	SER138
A	GLY139
A	SER140
A	ARG143
A	SER190
A	HIS194

site_id	AC2
Number of Residues	17
Details	binding site for residue PMV B 401

Chain	Residue
B	ALA13
B	LYS16
B	TYR17
B	SER106
B	SER138
B	GLY139
B	SER140
B	ARG143
B	SER190
B	HIS194
B	ASP280
B	HOH522
B	HOH536
B	HOH547
B	HOH557
B	HOH683
B	HOH716

site_id	AC3
Number of Residues	15
Details	binding site for residue PMV C 401

Chain	Residue
C	ALA13
C	LYS16
C	TYR17
C	SER138
C	GLY139
C	SER140
C	ARG143
C	SER190
C	HIS194
C	ASP280
C	HOH530
C	HOH532
C	HOH535
C	HOH578
C	HOH682

site_id	AC4
Number of Residues	14
Details	binding site for residue PMV D 401

Chain	Residue
D	ALA13
D	LYS16
D	TYR17
D	SER138
D	GLY139
D	SER140
D	ARG143
D	SER190
D	HIS194
D	ASP280
D	HOH509
D	HOH523
D	HOH534
D	HOH705

site_id	AC5
Number of Residues	15
Details	binding site for residue PMV E 401

Chain	Residue
E	ALA13
E	LYS16
E	TYR17
E	SER106
E	SER138
E	GLY139
E	SER140
E	ARG143
E	SER190
E	HIS194
E	ASP280
E	HOH512
E	HOH540
E	HOH579
E	HOH655

site_id	AC6
Number of Residues	14
Details	binding site for residue PMV F 401

Chain	Residue
F	ALA13
F	LYS16
F	TYR17
F	SER138
F	GLY139
F	SER140
F	ARG143
F	SER190
F	HIS194
F	ASP280
F	HOH536
F	HOH541
F	HOH637
F	HOH655

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)