Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6MZE

Structural Basis of Tubulin Recruitment and Assembly by Microtubule Polymerases with Tumor Overexpressed Gene (TOG) Domain Arrays

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000278	biological_process	mitotic cell cycle
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0005929	cellular_component	cilium
A	0007017	biological_process	microtubule-based process
A	0016787	molecular_function	hydrolase activity
A	0031514	cellular_component	motile cilium
A	0042995	cellular_component	cell projection
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000278	biological_process	mitotic cell cycle
B	0001764	biological_process	neuron migration
B	0003924	molecular_function	GTPase activity
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0007017	biological_process	microtubule-based process
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0000226	biological_process	microtubule cytoskeleton organization
C	0000278	biological_process	mitotic cell cycle
C	0005200	molecular_function	structural constituent of cytoskeleton
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0005929	cellular_component	cilium
C	0007017	biological_process	microtubule-based process
C	0016787	molecular_function	hydrolase activity
C	0031514	cellular_component	motile cilium
C	0042995	cellular_component	cell projection
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0000226	biological_process	microtubule cytoskeleton organization
D	0000278	biological_process	mitotic cell cycle
D	0001764	biological_process	neuron migration
D	0003924	molecular_function	GTPase activity
D	0005200	molecular_function	structural constituent of cytoskeleton
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005737	cellular_component	cytoplasm
D	0005856	cellular_component	cytoskeleton
D	0005874	cellular_component	microtubule
D	0007017	biological_process	microtubule-based process
D	0046872	molecular_function	metal ion binding
E	0000022	biological_process	mitotic spindle elongation
E	0000776	cellular_component	kinetochore
E	0005737	cellular_component	cytoplasm
E	0005816	cellular_component	spindle pole body
E	0005856	cellular_component	cytoskeleton
E	0005881	cellular_component	cytoplasmic microtubule
E	0007051	biological_process	spindle organization
E	0015631	molecular_function	tubulin binding
E	0030951	biological_process	establishment or maintenance of microtubule cytoskeleton polarity
E	0031109	biological_process	microtubule polymerization or depolymerization
E	0044732	cellular_component	mitotic spindle pole body
E	0046785	biological_process	microtubule polymerization
E	0051010	molecular_function	microtubule plus-end binding
E	0051315	biological_process	attachment of mitotic spindle microtubules to kinetochore
E	0061863	molecular_function	microtubule plus end polymerase
E	0099070	cellular_component	static microtubule bundle
E	1990498	cellular_component	mitotic spindle microtubule
E	1990571	biological_process	meiotic centromere clustering
H	0000166	molecular_function	nucleotide binding
H	0000226	biological_process	microtubule cytoskeleton organization
H	0000278	biological_process	mitotic cell cycle
H	0005200	molecular_function	structural constituent of cytoskeleton
H	0005525	molecular_function	GTP binding
H	0005737	cellular_component	cytoplasm
H	0005856	cellular_component	cytoskeleton
H	0005874	cellular_component	microtubule
H	0005929	cellular_component	cilium
H	0007017	biological_process	microtubule-based process
H	0016787	molecular_function	hydrolase activity
H	0031514	cellular_component	motile cilium
H	0042995	cellular_component	cell projection
H	0046872	molecular_function	metal ion binding
I	0000166	molecular_function	nucleotide binding
I	0000226	biological_process	microtubule cytoskeleton organization
I	0000278	biological_process	mitotic cell cycle
I	0001764	biological_process	neuron migration
I	0003924	molecular_function	GTPase activity
I	0005200	molecular_function	structural constituent of cytoskeleton
I	0005515	molecular_function	protein binding
I	0005525	molecular_function	GTP binding
I	0005737	cellular_component	cytoplasm
I	0005856	cellular_component	cytoskeleton
I	0005874	cellular_component	microtubule
I	0007017	biological_process	microtubule-based process
I	0046872	molecular_function	metal ion binding
J	0000166	molecular_function	nucleotide binding
J	0000226	biological_process	microtubule cytoskeleton organization
J	0000278	biological_process	mitotic cell cycle
J	0005200	molecular_function	structural constituent of cytoskeleton
J	0005525	molecular_function	GTP binding
J	0005737	cellular_component	cytoplasm
J	0005856	cellular_component	cytoskeleton
J	0005874	cellular_component	microtubule
J	0005929	cellular_component	cilium
J	0007017	biological_process	microtubule-based process
J	0016787	molecular_function	hydrolase activity
J	0031514	cellular_component	motile cilium
J	0042995	cellular_component	cell projection
J	0046872	molecular_function	metal ion binding
K	0000166	molecular_function	nucleotide binding
K	0000226	biological_process	microtubule cytoskeleton organization
K	0000278	biological_process	mitotic cell cycle
K	0001764	biological_process	neuron migration
K	0003924	molecular_function	GTPase activity
K	0005200	molecular_function	structural constituent of cytoskeleton
K	0005515	molecular_function	protein binding
K	0005525	molecular_function	GTP binding
K	0005737	cellular_component	cytoplasm
K	0005856	cellular_component	cytoskeleton
K	0005874	cellular_component	microtubule
K	0007017	biological_process	microtubule-based process
K	0046872	molecular_function	metal ion binding
L	0000022	biological_process	mitotic spindle elongation
L	0000776	cellular_component	kinetochore
L	0005737	cellular_component	cytoplasm
L	0005816	cellular_component	spindle pole body
L	0005856	cellular_component	cytoskeleton
L	0005881	cellular_component	cytoplasmic microtubule
L	0007051	biological_process	spindle organization
L	0015631	molecular_function	tubulin binding
L	0030951	biological_process	establishment or maintenance of microtubule cytoskeleton polarity
L	0031109	biological_process	microtubule polymerization or depolymerization
L	0044732	cellular_component	mitotic spindle pole body
L	0046785	biological_process	microtubule polymerization
L	0051010	molecular_function	microtubule plus-end binding
L	0051315	biological_process	attachment of mitotic spindle microtubules to kinetochore
L	0061863	molecular_function	microtubule plus end polymerase
L	0099070	cellular_component	static microtubule bundle
L	1990498	cellular_component	mitotic spindle microtubule
L	1990571	biological_process	meiotic centromere clustering
O	0000166	molecular_function	nucleotide binding
O	0000226	biological_process	microtubule cytoskeleton organization
O	0000278	biological_process	mitotic cell cycle
O	0005200	molecular_function	structural constituent of cytoskeleton
O	0005525	molecular_function	GTP binding
O	0005737	cellular_component	cytoplasm
O	0005856	cellular_component	cytoskeleton
O	0005874	cellular_component	microtubule
O	0005929	cellular_component	cilium
O	0007017	biological_process	microtubule-based process
O	0016787	molecular_function	hydrolase activity
O	0031514	cellular_component	motile cilium
O	0042995	cellular_component	cell projection
O	0046872	molecular_function	metal ion binding
P	0000166	molecular_function	nucleotide binding
P	0000226	biological_process	microtubule cytoskeleton organization
P	0000278	biological_process	mitotic cell cycle
P	0001764	biological_process	neuron migration
P	0003924	molecular_function	GTPase activity
P	0005200	molecular_function	structural constituent of cytoskeleton
P	0005515	molecular_function	protein binding
P	0005525	molecular_function	GTP binding
P	0005737	cellular_component	cytoplasm
P	0005856	cellular_component	cytoskeleton
P	0005874	cellular_component	microtubule
P	0007017	biological_process	microtubule-based process
P	0046872	molecular_function	metal ion binding
Q	0000166	molecular_function	nucleotide binding
Q	0000226	biological_process	microtubule cytoskeleton organization
Q	0000278	biological_process	mitotic cell cycle
Q	0005200	molecular_function	structural constituent of cytoskeleton
Q	0005525	molecular_function	GTP binding
Q	0005737	cellular_component	cytoplasm
Q	0005856	cellular_component	cytoskeleton
Q	0005874	cellular_component	microtubule
Q	0005929	cellular_component	cilium
Q	0007017	biological_process	microtubule-based process
Q	0016787	molecular_function	hydrolase activity
Q	0031514	cellular_component	motile cilium
Q	0042995	cellular_component	cell projection
Q	0046872	molecular_function	metal ion binding
R	0000166	molecular_function	nucleotide binding
R	0000226	biological_process	microtubule cytoskeleton organization
R	0000278	biological_process	mitotic cell cycle
R	0001764	biological_process	neuron migration
R	0003924	molecular_function	GTPase activity
R	0005200	molecular_function	structural constituent of cytoskeleton
R	0005515	molecular_function	protein binding
R	0005525	molecular_function	GTP binding
R	0005737	cellular_component	cytoplasm
R	0005856	cellular_component	cytoskeleton
R	0005874	cellular_component	microtubule
R	0007017	biological_process	microtubule-based process
R	0046872	molecular_function	metal ion binding
S	0000022	biological_process	mitotic spindle elongation
S	0000776	cellular_component	kinetochore
S	0005737	cellular_component	cytoplasm
S	0005816	cellular_component	spindle pole body
S	0005856	cellular_component	cytoskeleton
S	0005881	cellular_component	cytoplasmic microtubule
S	0007051	biological_process	spindle organization
S	0015631	molecular_function	tubulin binding
S	0030951	biological_process	establishment or maintenance of microtubule cytoskeleton polarity
S	0031109	biological_process	microtubule polymerization or depolymerization
S	0044732	cellular_component	mitotic spindle pole body
S	0046785	biological_process	microtubule polymerization
S	0051010	molecular_function	microtubule plus-end binding
S	0051315	biological_process	attachment of mitotic spindle microtubules to kinetochore
S	0061863	molecular_function	microtubule plus end polymerase
S	0099070	cellular_component	static microtubule bundle
S	1990498	cellular_component	mitotic spindle microtubule
S	1990571	biological_process	meiotic centromere clustering
V	0000166	molecular_function	nucleotide binding
V	0000226	biological_process	microtubule cytoskeleton organization
V	0000278	biological_process	mitotic cell cycle
V	0005200	molecular_function	structural constituent of cytoskeleton
V	0005525	molecular_function	GTP binding
V	0005737	cellular_component	cytoplasm
V	0005856	cellular_component	cytoskeleton
V	0005874	cellular_component	microtubule
V	0005929	cellular_component	cilium
V	0007017	biological_process	microtubule-based process
V	0016787	molecular_function	hydrolase activity
V	0031514	cellular_component	motile cilium
V	0042995	cellular_component	cell projection
V	0046872	molecular_function	metal ion binding
W	0000166	molecular_function	nucleotide binding
W	0000226	biological_process	microtubule cytoskeleton organization
W	0000278	biological_process	mitotic cell cycle
W	0001764	biological_process	neuron migration
W	0003924	molecular_function	GTPase activity
W	0005200	molecular_function	structural constituent of cytoskeleton
W	0005515	molecular_function	protein binding
W	0005525	molecular_function	GTP binding
W	0005737	cellular_component	cytoplasm
W	0005856	cellular_component	cytoskeleton
W	0005874	cellular_component	microtubule
W	0007017	biological_process	microtubule-based process
W	0046872	molecular_function	metal ion binding
X	0000166	molecular_function	nucleotide binding
X	0000226	biological_process	microtubule cytoskeleton organization
X	0000278	biological_process	mitotic cell cycle
X	0005200	molecular_function	structural constituent of cytoskeleton
X	0005525	molecular_function	GTP binding
X	0005737	cellular_component	cytoplasm
X	0005856	cellular_component	cytoskeleton
X	0005874	cellular_component	microtubule
X	0005929	cellular_component	cilium
X	0007017	biological_process	microtubule-based process
X	0016787	molecular_function	hydrolase activity
X	0031514	cellular_component	motile cilium
X	0042995	cellular_component	cell projection
X	0046872	molecular_function	metal ion binding
Y	0000166	molecular_function	nucleotide binding
Y	0000226	biological_process	microtubule cytoskeleton organization
Y	0000278	biological_process	mitotic cell cycle
Y	0001764	biological_process	neuron migration
Y	0003924	molecular_function	GTPase activity
Y	0005200	molecular_function	structural constituent of cytoskeleton
Y	0005515	molecular_function	protein binding
Y	0005525	molecular_function	GTP binding
Y	0005737	cellular_component	cytoplasm
Y	0005856	cellular_component	cytoskeleton
Y	0005874	cellular_component	microtubule
Y	0007017	biological_process	microtubule-based process
Y	0046872	molecular_function	metal ion binding
Z	0000022	biological_process	mitotic spindle elongation
Z	0000776	cellular_component	kinetochore
Z	0005737	cellular_component	cytoplasm
Z	0005816	cellular_component	spindle pole body
Z	0005856	cellular_component	cytoskeleton
Z	0005881	cellular_component	cytoplasmic microtubule
Z	0007051	biological_process	spindle organization
Z	0015631	molecular_function	tubulin binding
Z	0030951	biological_process	establishment or maintenance of microtubule cytoskeleton polarity
Z	0031109	biological_process	microtubule polymerization or depolymerization
Z	0044732	cellular_component	mitotic spindle pole body
Z	0046785	biological_process	microtubule polymerization
Z	0051010	molecular_function	microtubule plus-end binding
Z	0051315	biological_process	attachment of mitotic spindle microtubules to kinetochore
Z	0061863	molecular_function	microtubule plus end polymerase
Z	0099070	cellular_component	static microtubule bundle
Z	1990498	cellular_component	mitotic spindle microtubule
Z	1990571	biological_process	meiotic centromere clustering

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	binding site for residue GTP A 600

Chain	Residue
A	GLY10
A	GLY143
A	GLY144
A	THR145
A	GLY146
A	ILE171
A	VAL177
A	GLU183
A	ASN206
A	TYR224
A	ASN228
A	GLN11
A	ILE231
A	MG601
B	LYS254
A	ALA12
A	GLN15
A	ASP98
A	ALA99
A	ALA100
A	ASN101
A	SER140

site_id	AC2
Number of Residues	2
Details	binding site for residue MG A 601

Chain	Residue
A	GLU71
A	GTP600

site_id	AC3
Number of Residues	16
Details	binding site for residue GDP B 600

Chain	Residue
B	GLY10
B	GLN11
B	CYS12
B	GLN15
B	SER140
B	GLY143
B	GLY144
B	THR145
B	GLY146
B	PRO173
B	VAL177
B	GLU183
B	ASN206
B	TYR224
B	ASN228
B	MG601

site_id	AC4
Number of Residues	2
Details	binding site for residue MG B 601

Chain	Residue
B	GLN11
B	GDP600

site_id	AC5
Number of Residues	21
Details	binding site for residue GTP C 600

Chain	Residue
C	GLY10
C	GLN11
C	ALA12
C	GLN15
C	ASP98
C	ALA99
C	ALA100
C	ASN101
C	SER140
C	GLY143
C	GLY144
C	THR145
C	GLY146
C	VAL177
C	GLU183
C	ASN206
C	TYR224
C	ASN228
C	ILE231
C	MG601
D	LYS254

site_id	AC6
Number of Residues	2
Details	binding site for residue MG C 601

Chain	Residue
C	GLU71
C	GTP600

site_id	AC7
Number of Residues	16
Details	binding site for residue GDP D 600

Chain	Residue
D	GLY10
D	GLN11
D	CYS12
D	GLN15
D	SER140
D	GLY143
D	GLY144
D	THR145
D	GLY146
D	PRO173
D	VAL177
D	GLU183
D	ASN206
D	TYR224
D	ASN228
D	MG601

site_id	AC8
Number of Residues	1
Details	binding site for residue MG D 601

Chain	Residue
D	GDP600

site_id	AC9
Number of Residues	22
Details	binding site for residue GTP H 600

Chain	Residue
H	TYR224
H	ASN228
H	ILE231
H	MG601
I	LYS254
H	GLY10
H	GLN11
H	ALA12
H	GLN15
H	ILE16
H	ASP98
H	ALA99
H	ALA100
H	ASN101
H	SER140
H	GLY143
H	GLY144
H	THR145
H	GLY146
H	VAL177
H	GLU183
H	ASN206

site_id	AD1
Number of Residues	2
Details	binding site for residue MG H 601

Chain	Residue
H	GLU71
H	GTP600

site_id	AD2
Number of Residues	16
Details	binding site for residue GDP I 600

Chain	Residue
I	GLY10
I	GLN11
I	CYS12
I	GLN15
I	SER140
I	GLY143
I	GLY144
I	THR145
I	GLY146
I	PRO173
I	VAL177
I	GLU183
I	ASN206
I	TYR224
I	ASN228
I	MG601

site_id	AD3
Number of Residues	3
Details	binding site for residue MG I 601

Chain	Residue
I	GLN11
I	ASP69
I	GDP600

site_id	AD4
Number of Residues	22
Details	binding site for residue GTP J 600

Chain	Residue
J	GLY10
J	GLN11
J	ALA12
J	GLN15
J	ASP98
J	ALA99
J	ALA100
J	ASN101
J	SER140
J	GLY143
J	GLY144
J	THR145
J	GLY146
J	ILE171
J	VAL177
J	GLU183
J	ASN206
J	TYR224
J	ASN228
J	ILE231
J	MG601
K	LYS254

site_id	AD5
Number of Residues	2
Details	binding site for residue MG J 601

Chain	Residue
J	GLU71
J	GTP600

site_id	AD6
Number of Residues	16
Details	binding site for residue GDP K 600

Chain	Residue
K	GLY10
K	GLN11
K	CYS12
K	GLN15
K	SER140
K	GLY143
K	GLY144
K	THR145
K	GLY146
K	PRO173
K	VAL177
K	GLU183
K	ASN206
K	TYR224
K	ASN228
K	MG601

site_id	AD7
Number of Residues	4
Details	binding site for residue MG K 601

Chain	Residue
K	GLN11
K	ASP69
K	GLU71
K	GDP600

site_id	AD8
Number of Residues	22
Details	binding site for residue GTP O 600

Chain	Residue
O	GLY10
O	GLN11
O	ALA12
O	GLN15
O	ASP98
O	ALA99
O	ALA100
O	ASN101
O	SER140
O	GLY143
O	GLY144
O	THR145
O	GLY146
O	ILE171
O	VAL177
O	GLU183
O	ASN206
O	TYR224
O	ASN228
O	ILE231
O	MG601
P	LYS254

site_id	AD9
Number of Residues	2
Details	binding site for residue MG O 601

Chain	Residue
O	GLU71
O	GTP600

site_id	AE1
Number of Residues	16
Details	binding site for residue GDP P 600

Chain	Residue
P	GLY10
P	GLN11
P	CYS12
P	GLN15
P	SER140
P	GLY143
P	GLY144
P	THR145
P	GLY146
P	PRO173
P	VAL177
P	GLU183
P	ASN206
P	TYR224
P	ASN228
P	MG601

site_id	AE2
Number of Residues	2
Details	binding site for residue MG P 601

Chain	Residue
P	GLN11
P	GDP600

site_id	AE3
Number of Residues	22
Details	binding site for residue GTP Q 600

Chain	Residue
Q	GLY10
Q	GLN11
Q	ALA12
Q	GLN15
Q	ASP98
Q	ALA99
Q	ALA100
Q	ASN101
Q	SER140
Q	GLY143
Q	GLY144
Q	THR145
Q	GLY146
Q	ILE171
Q	VAL177
Q	GLU183
Q	ASN206
Q	TYR224
Q	ASN228
Q	ILE231
Q	MG601
R	LYS254

site_id	AE4
Number of Residues	2
Details	binding site for residue MG Q 601

Chain	Residue
Q	GLU71
Q	GTP600

site_id	AE5
Number of Residues	16
Details	binding site for residue GDP R 600

Chain	Residue
R	GLY10
R	GLN11
R	CYS12
R	GLN15
R	SER140
R	GLY143
R	GLY144
R	THR145
R	GLY146
R	PRO173
R	VAL177
R	GLU183
R	ASN206
R	TYR224
R	ASN228
R	MG601

site_id	AE6
Number of Residues	3
Details	binding site for residue MG R 601

Chain	Residue
R	GLN11
R	ASP69
R	GDP600

site_id	AE7
Number of Residues	22
Details	binding site for residue GTP V 600

Chain	Residue
V	GLY10
V	GLN11
V	ALA12
V	GLN15
V	ASP98
V	ALA99
V	ALA100
V	ASN101
V	SER140
V	GLY143
V	GLY144
V	THR145
V	GLY146
V	ILE171
V	VAL177
V	GLU183
V	ASN206
V	TYR224
V	ASN228
V	ILE231
V	MG601
W	LYS254

site_id	AE8
Number of Residues	2
Details	binding site for residue MG V 601

Chain	Residue
V	GLU71
V	GTP600

site_id	AE9
Number of Residues	16
Details	binding site for residue GDP W 600

Chain	Residue
W	GLY10
W	GLN11
W	CYS12
W	GLN15
W	SER140
W	GLY143
W	GLY144
W	THR145
W	GLY146
W	PRO173
W	VAL177
W	GLU183
W	ASN206
W	TYR224
W	ASN228
W	MG601

site_id	AF1
Number of Residues	3
Details	binding site for residue MG W 601

Chain	Residue
W	ASP69
W	GLU71
W	GDP600

site_id	AF2
Number of Residues	22
Details	binding site for residue GTP X 600

Chain	Residue
X	GLY10
X	GLN11
X	ALA12
X	GLN15
X	ASP98
X	ALA99
X	ALA100
X	ASN101
X	SER140
X	GLY143
X	GLY144
X	THR145
X	GLY146
X	ILE171
X	VAL177
X	GLU183
X	ASN206
X	TYR224
X	ASN228
X	ILE231
X	MG601
Y	LYS254

site_id	AF3
Number of Residues	2
Details	binding site for residue MG X 601

Chain	Residue
X	GLU71
X	GTP600

site_id	AF4
Number of Residues	16
Details	binding site for residue GDP Y 600

Chain	Residue
Y	GLY10
Y	GLN11
Y	CYS12
Y	GLN15
Y	SER140
Y	GLY143
Y	GLY144
Y	THR145
Y	GLY146
Y	PRO173
Y	VAL177
Y	GLU183
Y	ASN206
Y	TYR224
Y	ASN228
Y	MG601

site_id	AF5
Number of Residues	2
Details	binding site for residue MG Y 601

Chain	Residue
Y	GLN11
Y	GDP600

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
B	GLY142-GLY148
A	GLY142-GLY148

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
B	MET1-ILE4

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	56
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:Q13509

Chain	Residue	Details
B	GLN11
D	GLY144
D	THR145
D	GLY146
D	ASN206
D	ASN228
I	GLN11
I	SER140
I	GLY144
I	THR145
I	GLY146
B	SER140
I	ASN206
I	ASN228
K	GLN11
K	SER140
K	GLY144
K	THR145
K	GLY146
K	ASN206
K	ASN228
P	GLN11
B	GLY144
P	SER140
P	GLY144
P	THR145
P	GLY146
P	ASN206
P	ASN228
R	GLN11
R	SER140
R	GLY144
R	THR145
B	THR145
R	GLY146
R	ASN206
R	ASN228
W	GLN11
W	SER140
W	GLY144
W	THR145
W	GLY146
W	ASN206
W	ASN228
B	GLY146
Y	GLN11
Y	SER140
Y	GLY144
Y	THR145
Y	GLY146
Y	ASN206
Y	ASN228
B	ASN206
B	ASN228
D	GLN11
D	SER140

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P68363

Chain	Residue	Details
B	GLU71
C	GLU71
C	SER140
C	GLY144
C	THR145
C	THR179
C	ASN206
C	ASN228
H	GLN11
H	GLU71
H	SER140
D	GLU71
H	GLY144
H	THR145
H	THR179
H	ASN206
H	ASN228
J	GLN11
J	GLU71
J	SER140
J	GLY144
J	THR145
I	GLU71
J	THR179
J	ASN206
J	ASN228
O	GLN11
O	GLU71
O	SER140
O	GLY144
O	THR145
O	THR179
O	ASN206
K	GLU71
O	ASN228
Q	GLN11
Q	GLU71
Q	SER140
Q	GLY144
Q	THR145
Q	THR179
Q	ASN206
Q	ASN228
V	GLN11
P	GLU71
V	GLU71
V	SER140
V	GLY144
V	THR145
V	THR179
V	ASN206
V	ASN228
X	GLN11
X	GLU71
X	SER140
R	GLU71
X	GLY144
X	THR145
X	THR179
X	ASN206
X	ASN228
W	GLU71
Y	GLU71
C	GLN11

site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P99024

Chain	Residue	Details
B	SER40
D	SER40
I	SER40
K	SER40
P	SER40
R	SER40
W	SER40
Y	SER40

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:P99024

Chain	Residue	Details
B	LYS60
D	LYS60
I	LYS60
K	LYS60
P	LYS60
R	LYS60
W	LYS60
Y	LYS60

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: Phosphoserine; by CDK1 => ECO:0000250\|UniProtKB:Q13885

Chain	Residue	Details
B	SER174
D	SER174
I	SER174
K	SER174
P	SER174
R	SER174
W	SER174
Y	SER174

site_id	SWS_FT_FI6
Number of Residues	16
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:P07437

Chain	Residue	Details
B	THR287
P	THR292
R	THR287
R	THR292
W	THR287
W	THR292
Y	THR287
Y	THR292
B	THR292
D	THR287
D	THR292
I	THR287
I	THR292
K	THR287
K	THR292
P	THR287

site_id	SWS_FT_FI7
Number of Residues	8
Details	MOD_RES: Omega-N-methylarginine => ECO:0000250\|UniProtKB:P07437

Chain	Residue	Details
B	ARG320
D	ARG320
I	ARG320
K	ARG320
P	ARG320
R	ARG320
W	ARG320
Y	ARG320

site_id	SWS_FT_FI8
Number of Residues	8
Details	MOD_RES: 5-glutamyl polyglutamate => ECO:0000250\|UniProtKB:Q2T9S0

Chain	Residue	Details
B	GLU448
D	GLU448
I	GLU448
K	GLU448
P	GLU448
R	GLU448
W	GLU448
Y	GLU448

site_id	SWS_FT_FI9
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250\|UniProtKB:P07437

Chain	Residue	Details
B	LYS60
D	LYS60
I	LYS60
K	LYS60
P	LYS60
R	LYS60
W	LYS60
Y	LYS60

site_id	SWS_FT_FI10
Number of Residues	16
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250\|UniProtKB:P07437

Chain	Residue	Details
P	LYS326
R	LYS326
W	LYS326
Y	LYS326
B	LYS326
D	LYS326
I	LYS326
K	LYS326

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)