6MWS

crystal structure of the reduced Grx1 from Saccharomyces cerevisiae

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004364	molecular_function	glutathione transferase activity
A	0004602	molecular_function	glutathione peroxidase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0010731	biological_process	protein glutathionylation
A	0015038	molecular_function	glutathione disulfide oxidoreductase activity
A	0016491	molecular_function	oxidoreductase activity
A	0016740	molecular_function	transferase activity
A	0034599	biological_process	cellular response to oxidative stress
A	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue SO4 A 201

Chain	Residue
A	LYS40
A	GLN72
A	ARG73
A	THR74
A	ARG95
A	HOH325
A	HOH371

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Functional Information from PROSITE/UniProt

site_id	PS00195
Number of Residues	17
Details	GLUTAREDOXIN_1 Glutaredoxin active site. VAsktyCPYChaAlntL

Chain	Residue	Details
A	VAL21-LEU37

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:17327665, ECO:0000269|PubMed:18473363

Chain	Residue	Details
A	LYS24
A	GLN63
A	VAL75
A	ASN88

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: S-glutathionyl cysteine; alternate => ECO:0000269|PubMed:17327665, ECO:0000269|PubMed:18473363

Chain	Residue	Details
A	CYS27

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047

Chain	Residue	Details
A	LYS11

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