Functional Information from GO Data
| Chain | GOid | namespace | contents |
| C | 0004748 | molecular_function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005971 | cellular_component | ribonucleoside-diphosphate reductase complex |
| C | 0009263 | biological_process | deoxyribonucleotide biosynthetic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| D | 0004748 | molecular_function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005971 | cellular_component | ribonucleoside-diphosphate reductase complex |
| D | 0009263 | biological_process | deoxyribonucleotide biosynthetic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue DTP C 1001 |
| Chain | Residue |
| C | ASP177 |
| C | SER178 |
| C | LEU179 |
| C | ARG207 |
| C | ILE213 |
| C | LYS214 |
| D | LYS194 |
| D | TYR236 |
| D | ALA237 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue DTP C 1002 |
| Chain | Residue |
| C | VAL33 |
| C | HIS34 |
| C | PHE37 |
| C | ASN42 |
| C | ARG90 |
| C | PHE91 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue DTP D 1001 |
| Chain | Residue |
| C | LYS194 |
| C | TYR236 |
| C | ALA237 |
| D | ASP177 |
| D | SER178 |
| D | LEU179 |
| D | ARG207 |
| D | ILE213 |
| D | LYS214 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue DTP D 1002 |
| Chain | Residue |
| D | VAL33 |
| D | HIS34 |
| D | PHE37 |
| D | ASN42 |
| D | ARG90 |
| D | PHE91 |
Functional Information from PROSITE/UniProt
| site_id | PS00089 |
| Number of Residues | 23 |
| Details | RIBORED_LARGE Ribonucleotide reductase large subunit signature. WkkLkafvaehGMYHsyrLCiaP |
| Chain | Residue | Details |
| C | TRP558-PRO580 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000250 |
| Chain | Residue | Details |
| C | ASN380 | |
| C | GLU384 | |
| D | ASN380 | |
| D | GLU384 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Cysteine radical intermediate => ECO:0000250 |
| Chain | Residue | Details |
| C | CYS382 | |
| D | CYS382 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| C | THR153 | |
| D | PRO580 | |
| C | SER169 | |
| C | GLY198 | |
| C | ASN380 | |
| C | PRO580 | |
| D | THR153 | |
| D | SER169 | |
| D | GLY198 | |
| D | ASN380 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | SITE: Important for hydrogen atom transfer => ECO:0000250 |
| Chain | Residue | Details |
| C | CYS170 | |
| C | CYS409 | |
| D | CYS170 | |
| D | CYS409 | |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | SITE: Allosteric effector binding => ECO:0000250 |
| Chain | Residue | Details |
| C | ASP177 | |
| C | ARG207 | |
| D | ASP177 | |
| D | ARG207 | |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | SITE: Important for electron transfer => ECO:0000250 |
| Chain | Residue | Details |
| C | TYR683 | |
| C | TYR684 | |
| D | TYR683 | |
| D | TYR684 | |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | SITE: Interacts with thioredoxin/glutaredoxin => ECO:0000250 |
| Chain | Residue | Details |
| C | CYS695 | |
| C | CYS698 | |
| D | CYS695 | |
| D | CYS698 | |
