6MV4

CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR IXa

Functional Information from GO Data

Chain	GOid	namespace	contents
H	0004252	molecular_function	serine-type endopeptidase activity
H	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue SO4 H 301

Chain	Residue
H	LYS132
H	ARG165
H	LYS230
H	SO4302
H	HOH443
H	HOH491
H	HOH535

---

site_id	AC2
Number of Residues	7
Details	binding site for residue SO4 H 302

Chain	Residue
H	SO4301
H	HOH424
H	HOH467
H	HOH487
H	HOH508
H	ASN129
H	LYS132

---

site_id	AC3
Number of Residues	5
Details	binding site for residue SO4 H 303

Chain	Residue
H	LYS126
H	ARG233
H	HOH416
H	HOH419
H	HOH466

---

site_id	AC4
Number of Residues	6
Details	binding site for residue SO4 H 304

Chain	Residue
H	GLU127
H	TYR128
H	ILE129
L	CYS88
L	ASN92
L	HOH208

---

site_id	AC5
Number of Residues	7
Details	binding site for residue SO4 H 305

Chain	Residue
H	ASN178
H	ASN178
H	ARG233
H	ARG233
H	HOH493
H	HOH542
H	HOH681

---

site_id	AC6
Number of Residues	7
Details	binding site for residue SO4 H 306

Chain	Residue
H	ASN97
H	PHE174
H	THR175
H	TYR177
H	HOH496
H	HOH587
H	HOH594

---

site_id	AC7
Number of Residues	8
Details	binding site for residue EDO H 307

Chain	Residue
H	GLY19
H	GLU20
H	TYR157
H	LEU158
H	ARG159
H	HOH422
H	HOH503
H	HOH591

---

site_id	AC8
Number of Residues	3
Details	binding site for residue EDO H 308

Chain	Residue
H	LEU162
H	LEU162
H	HOH431

---

site_id	AC9
Number of Residues	4
Details	binding site for residue FMT H 309

Chain	Residue
H	HOH423
H	HOH485
H	HOH496
H	HOH592

---

site_id	AD1
Number of Residues	12
Details	binding site for residue PBZ H 310

Chain	Residue
H	ASP189
H	SER190
H	CYS191
H	GLN192
H	SER195
H	TRP215
H	GLY216
H	GLU217
H	CYS220
H	GLY226
H	HOH523
H	HOH569

---

site_id	AD2
Number of Residues	7
Details	binding site for residue CA H 311

Chain	Residue
H	GLU70
H	ASN72
H	ILE73
H	GLU75
H	GLU77
H	GLU80
H	HOH411

---

site_id	AD3
Number of Residues	7
Details	binding site for residue NA H 312

Chain	Residue
H	PHE184
H	HIS185
H	GLY187
H	MET221
H	LYS224
H	HOH543
H	HOH593

---

site_id	AD4
Number of Residues	3
Details	binding site for residue CL H 313

Chain	Residue
H	LYS241
H	HOH459
H	HOH765

---

site_id	AD5
Number of Residues	2
Details	binding site for residue CL H 314

Chain	Residue
H	ARG188
H	HOH541

---

site_id	AD6
Number of Residues	2
Details	binding site for residue CL H 315

Chain	Residue
H	PHE133
H	HIS185

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VTAAHC

Chain	Residue	Details
H	VAL53-CYS58

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPHV

Chain	Residue	Details
H	ASP189-VAL200

---

site_id	PS01186
Number of Residues	16
Details	EGF_2 EGF-like domain signature 2. CsCteGYrlaenqksC

Chain	Residue	Details
L	CYS109-CYS124

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	232
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"20004170","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"659613","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"659613","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10467148","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20004170","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20080729","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20121197","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20121198","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1RFN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WPH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WPI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WPJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WPK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WPM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KCG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LC3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LC5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10467148","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20004170","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20080729","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20121197","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20121198","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2WPH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WPI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WPJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WPK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WPM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KCG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LC3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LC5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---