6MUV

The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000502	cellular_component	proteasome complex
A	0004175	molecular_function	endopeptidase activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005839	cellular_component	proteasome core complex
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0016787	molecular_function	hydrolase activity
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0051603	biological_process	proteolysis involved in protein catabolic process
B	0000502	cellular_component	proteasome complex
B	0004175	molecular_function	endopeptidase activity
B	0005839	cellular_component	proteasome core complex
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0016787	molecular_function	hydrolase activity
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0051603	biological_process	proteolysis involved in protein catabolic process
C	0000502	cellular_component	proteasome complex
C	0004175	molecular_function	endopeptidase activity
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005839	cellular_component	proteasome core complex
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0016787	molecular_function	hydrolase activity
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0051603	biological_process	proteolysis involved in protein catabolic process
D	0000502	cellular_component	proteasome complex
D	0004175	molecular_function	endopeptidase activity
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005839	cellular_component	proteasome core complex
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0016787	molecular_function	hydrolase activity
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0051603	biological_process	proteolysis involved in protein catabolic process
E	0000502	cellular_component	proteasome complex
E	0004175	molecular_function	endopeptidase activity
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005839	cellular_component	proteasome core complex
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0016787	molecular_function	hydrolase activity
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0051603	biological_process	proteolysis involved in protein catabolic process
F	0000502	cellular_component	proteasome complex
F	0004175	molecular_function	endopeptidase activity
F	0005839	cellular_component	proteasome core complex
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0016787	molecular_function	hydrolase activity
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0051603	biological_process	proteolysis involved in protein catabolic process
G	0000502	cellular_component	proteasome complex
G	0004175	molecular_function	endopeptidase activity
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005839	cellular_component	proteasome core complex
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0016787	molecular_function	hydrolase activity
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0051603	biological_process	proteolysis involved in protein catabolic process
H	0005839	cellular_component	proteasome core complex
H	0051603	biological_process	proteolysis involved in protein catabolic process
I	0004298	molecular_function	threonine-type endopeptidase activity
I	0005839	cellular_component	proteasome core complex
I	0051603	biological_process	proteolysis involved in protein catabolic process
J	0000502	cellular_component	proteasome complex
J	0004175	molecular_function	endopeptidase activity
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005839	cellular_component	proteasome core complex
J	0006511	biological_process	ubiquitin-dependent protein catabolic process
J	0016787	molecular_function	hydrolase activity
J	0019774	cellular_component	proteasome core complex, beta-subunit complex
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0051603	biological_process	proteolysis involved in protein catabolic process
K	0000502	cellular_component	proteasome complex
K	0004175	molecular_function	endopeptidase activity
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005839	cellular_component	proteasome core complex
K	0006511	biological_process	ubiquitin-dependent protein catabolic process
K	0010498	biological_process	proteasomal protein catabolic process
K	0016787	molecular_function	hydrolase activity
K	0019774	cellular_component	proteasome core complex, beta-subunit complex
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0051603	biological_process	proteolysis involved in protein catabolic process
L	0004298	molecular_function	threonine-type endopeptidase activity
L	0005839	cellular_component	proteasome core complex
L	0051603	biological_process	proteolysis involved in protein catabolic process
M	0005839	cellular_component	proteasome core complex
M	0051603	biological_process	proteolysis involved in protein catabolic process
N	0000502	cellular_component	proteasome complex
N	0005634	cellular_component	nucleus
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005839	cellular_component	proteasome core complex
N	0016787	molecular_function	hydrolase activity
N	0019774	cellular_component	proteasome core complex, beta-subunit complex
N	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
N	0051603	biological_process	proteolysis involved in protein catabolic process
O	0000502	cellular_component	proteasome complex
O	0004175	molecular_function	endopeptidase activity
O	0005634	cellular_component	nucleus
O	0005737	cellular_component	cytoplasm
O	0005839	cellular_component	proteasome core complex
O	0006511	biological_process	ubiquitin-dependent protein catabolic process
O	0016787	molecular_function	hydrolase activity
O	0019773	cellular_component	proteasome core complex, alpha-subunit complex
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	0051603	biological_process	proteolysis involved in protein catabolic process
P	0000502	cellular_component	proteasome complex
P	0004175	molecular_function	endopeptidase activity
P	0005839	cellular_component	proteasome core complex
P	0006511	biological_process	ubiquitin-dependent protein catabolic process
P	0016787	molecular_function	hydrolase activity
P	0019773	cellular_component	proteasome core complex, alpha-subunit complex
P	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
P	0051603	biological_process	proteolysis involved in protein catabolic process
Q	0000502	cellular_component	proteasome complex
Q	0004175	molecular_function	endopeptidase activity
Q	0005634	cellular_component	nucleus
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0005839	cellular_component	proteasome core complex
Q	0006511	biological_process	ubiquitin-dependent protein catabolic process
Q	0016787	molecular_function	hydrolase activity
Q	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Q	0051603	biological_process	proteolysis involved in protein catabolic process
R	0000502	cellular_component	proteasome complex
R	0004175	molecular_function	endopeptidase activity
R	0005634	cellular_component	nucleus
R	0005737	cellular_component	cytoplasm
R	0005839	cellular_component	proteasome core complex
R	0006511	biological_process	ubiquitin-dependent protein catabolic process
R	0016787	molecular_function	hydrolase activity
R	0019773	cellular_component	proteasome core complex, alpha-subunit complex
R	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
R	0051603	biological_process	proteolysis involved in protein catabolic process
S	0000502	cellular_component	proteasome complex
S	0004175	molecular_function	endopeptidase activity
S	0005634	cellular_component	nucleus
S	0005737	cellular_component	cytoplasm
S	0005839	cellular_component	proteasome core complex
S	0006511	biological_process	ubiquitin-dependent protein catabolic process
S	0016787	molecular_function	hydrolase activity
S	0019773	cellular_component	proteasome core complex, alpha-subunit complex
S	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
S	0051603	biological_process	proteolysis involved in protein catabolic process
T	0000502	cellular_component	proteasome complex
T	0004175	molecular_function	endopeptidase activity
T	0005839	cellular_component	proteasome core complex
T	0006511	biological_process	ubiquitin-dependent protein catabolic process
T	0016787	molecular_function	hydrolase activity
T	0019773	cellular_component	proteasome core complex, alpha-subunit complex
T	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
T	0051603	biological_process	proteolysis involved in protein catabolic process
U	0000502	cellular_component	proteasome complex
U	0004175	molecular_function	endopeptidase activity
U	0005634	cellular_component	nucleus
U	0005737	cellular_component	cytoplasm
U	0005839	cellular_component	proteasome core complex
U	0006511	biological_process	ubiquitin-dependent protein catabolic process
U	0016787	molecular_function	hydrolase activity
U	0019773	cellular_component	proteasome core complex, alpha-subunit complex
U	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
U	0051603	biological_process	proteolysis involved in protein catabolic process
V	0005839	cellular_component	proteasome core complex
V	0051603	biological_process	proteolysis involved in protein catabolic process
W	0004298	molecular_function	threonine-type endopeptidase activity
W	0005839	cellular_component	proteasome core complex
W	0051603	biological_process	proteolysis involved in protein catabolic process
X	0000502	cellular_component	proteasome complex
X	0004175	molecular_function	endopeptidase activity
X	0005634	cellular_component	nucleus
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0005839	cellular_component	proteasome core complex
X	0006511	biological_process	ubiquitin-dependent protein catabolic process
X	0016787	molecular_function	hydrolase activity
X	0019774	cellular_component	proteasome core complex, beta-subunit complex
X	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
X	0051603	biological_process	proteolysis involved in protein catabolic process
Y	0000502	cellular_component	proteasome complex
Y	0004175	molecular_function	endopeptidase activity
Y	0005634	cellular_component	nucleus
Y	0005737	cellular_component	cytoplasm
Y	0005829	cellular_component	cytosol
Y	0005839	cellular_component	proteasome core complex
Y	0006511	biological_process	ubiquitin-dependent protein catabolic process
Y	0010498	biological_process	proteasomal protein catabolic process
Y	0016787	molecular_function	hydrolase activity
Y	0019774	cellular_component	proteasome core complex, beta-subunit complex
Y	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Y	0051603	biological_process	proteolysis involved in protein catabolic process
Z	0004298	molecular_function	threonine-type endopeptidase activity
Z	0005839	cellular_component	proteasome core complex
Z	0051603	biological_process	proteolysis involved in protein catabolic process
a	0005839	cellular_component	proteasome core complex
a	0051603	biological_process	proteolysis involved in protein catabolic process
b	0000502	cellular_component	proteasome complex
b	0005634	cellular_component	nucleus
b	0005737	cellular_component	cytoplasm
b	0005829	cellular_component	cytosol
b	0005839	cellular_component	proteasome core complex
b	0016787	molecular_function	hydrolase activity
b	0019774	cellular_component	proteasome core complex, beta-subunit complex
b	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
b	0051603	biological_process	proteolysis involved in protein catabolic process
c	0000502	cellular_component	proteasome complex
c	0005654	cellular_component	nucleoplasm
c	0005737	cellular_component	cytoplasm
c	0008537	cellular_component	proteasome activator complex
c	0061133	molecular_function	endopeptidase activator activity
c	0061136	biological_process	regulation of proteasomal protein catabolic process
c	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
d	0000502	cellular_component	proteasome complex
d	0005654	cellular_component	nucleoplasm
d	0005737	cellular_component	cytoplasm
d	0008537	cellular_component	proteasome activator complex
d	0061133	molecular_function	endopeptidase activator activity
d	0061136	biological_process	regulation of proteasomal protein catabolic process
d	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
e	0000502	cellular_component	proteasome complex
e	0005654	cellular_component	nucleoplasm
e	0005737	cellular_component	cytoplasm
e	0008537	cellular_component	proteasome activator complex
e	0061133	molecular_function	endopeptidase activator activity
e	0061136	biological_process	regulation of proteasomal protein catabolic process
e	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
f	0000502	cellular_component	proteasome complex
f	0005654	cellular_component	nucleoplasm
f	0005737	cellular_component	cytoplasm
f	0008537	cellular_component	proteasome activator complex
f	0061133	molecular_function	endopeptidase activator activity
f	0061136	biological_process	regulation of proteasomal protein catabolic process
f	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
g	0000502	cellular_component	proteasome complex
g	0005654	cellular_component	nucleoplasm
g	0005737	cellular_component	cytoplasm
g	0008537	cellular_component	proteasome activator complex
g	0061133	molecular_function	endopeptidase activator activity
g	0061136	biological_process	regulation of proteasomal protein catabolic process
g	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
h	0000502	cellular_component	proteasome complex
h	0005654	cellular_component	nucleoplasm
h	0005737	cellular_component	cytoplasm
h	0008537	cellular_component	proteasome activator complex
h	0061133	molecular_function	endopeptidase activator activity
h	0061136	biological_process	regulation of proteasomal protein catabolic process
h	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
i	0000502	cellular_component	proteasome complex
i	0005654	cellular_component	nucleoplasm
i	0005737	cellular_component	cytoplasm
i	0008537	cellular_component	proteasome activator complex
i	0061133	molecular_function	endopeptidase activator activity
i	0061136	biological_process	regulation of proteasomal protein catabolic process
i	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
j	0000502	cellular_component	proteasome complex
j	0005654	cellular_component	nucleoplasm
j	0005737	cellular_component	cytoplasm
j	0008537	cellular_component	proteasome activator complex
j	0061133	molecular_function	endopeptidase activator activity
j	0061136	biological_process	regulation of proteasomal protein catabolic process
j	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
k	0000502	cellular_component	proteasome complex
k	0005654	cellular_component	nucleoplasm
k	0005737	cellular_component	cytoplasm
k	0008537	cellular_component	proteasome activator complex
k	0061133	molecular_function	endopeptidase activator activity
k	0061136	biological_process	regulation of proteasomal protein catabolic process
k	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
l	0000502	cellular_component	proteasome complex
l	0005654	cellular_component	nucleoplasm
l	0005737	cellular_component	cytoplasm
l	0008537	cellular_component	proteasome activator complex
l	0061133	molecular_function	endopeptidase activator activity
l	0061136	biological_process	regulation of proteasomal protein catabolic process
l	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
m	0000502	cellular_component	proteasome complex
m	0005654	cellular_component	nucleoplasm
m	0005737	cellular_component	cytoplasm
m	0008537	cellular_component	proteasome activator complex
m	0061133	molecular_function	endopeptidase activator activity
m	0061136	biological_process	regulation of proteasomal protein catabolic process
m	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
n	0000502	cellular_component	proteasome complex
n	0005654	cellular_component	nucleoplasm
n	0005737	cellular_component	cytoplasm
n	0008537	cellular_component	proteasome activator complex
n	0061133	molecular_function	endopeptidase activator activity
n	0061136	biological_process	regulation of proteasomal protein catabolic process
n	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
o	0000502	cellular_component	proteasome complex
o	0005654	cellular_component	nucleoplasm
o	0005737	cellular_component	cytoplasm
o	0008537	cellular_component	proteasome activator complex
o	0061133	molecular_function	endopeptidase activator activity
o	0061136	biological_process	regulation of proteasomal protein catabolic process
o	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
p	0000502	cellular_component	proteasome complex
p	0005654	cellular_component	nucleoplasm
p	0005737	cellular_component	cytoplasm
p	0008537	cellular_component	proteasome activator complex
p	0061133	molecular_function	endopeptidase activator activity
p	0061136	biological_process	regulation of proteasomal protein catabolic process
p	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle

Functional Information from PROSITE/UniProt

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdsrtTtFSPeGRlyQVEYAleA

Chain	Residue	Details
C	TYR5-ALA27
E	TYR8-ALA30
D	TYR3-ALA25

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site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. CGLvCqnAVILGADtrategpivadkncs.KlhyiskniwcagaGvaGD

Chain	Residue	Details
I	CYS4-ASP51
J	LEU13-ASP61
M	ILE41-ASP88
L	LEU4-ASP51
b	ILE13-ASP60
K	ILE5-ASP53

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