6MTW

Lysosomal Phospholipase A2 in complex with Zinc

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004622	molecular_function	lysophospholipase activity
A	0004623	molecular_function	phospholipase A2 activity
A	0005543	molecular_function	phospholipid binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005654	cellular_component	nucleoplasm
A	0005764	cellular_component	lysosome
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006644	biological_process	phospholipid metabolic process
A	0006650	biological_process	glycerophospholipid metabolic process
A	0006651	biological_process	diacylglycerol biosynthetic process
A	0006658	biological_process	phosphatidylserine metabolic process
A	0006672	biological_process	ceramide metabolic process
A	0008270	molecular_function	zinc ion binding
A	0008374	molecular_function	O-acyltransferase activity
A	0008970	molecular_function	phospholipase A1 activity
A	0009062	biological_process	fatty acid catabolic process
A	0016020	cellular_component	membrane
A	0016042	biological_process	lipid catabolic process
A	0016411	molecular_function	acylglycerol O-acyltransferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016787	molecular_function	hydrolase activity
A	0034638	biological_process	phosphatidylcholine catabolic process
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0046338	biological_process	phosphatidylethanolamine catabolic process
A	0046470	biological_process	phosphatidylcholine metabolic process
A	0046471	biological_process	phosphatidylglycerol metabolic process
A	0046872	molecular_function	metal ion binding
A	0047499	molecular_function	calcium-independent phospholipase A2 activity
A	0052739	molecular_function	phosphatidylserine 1-acylhydrolase activity
A	0052740	molecular_function	1-acyl-2-lysophosphatidylserine acylhydrolase activity
A	0070062	cellular_component	extracellular exosome
A	0102545	molecular_function	phosphatidyl phospholipase B activity
B	0004622	molecular_function	lysophospholipase activity
B	0004623	molecular_function	phospholipase A2 activity
B	0005543	molecular_function	phospholipid binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005654	cellular_component	nucleoplasm
B	0005764	cellular_component	lysosome
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0006644	biological_process	phospholipid metabolic process
B	0006650	biological_process	glycerophospholipid metabolic process
B	0006651	biological_process	diacylglycerol biosynthetic process
B	0006658	biological_process	phosphatidylserine metabolic process
B	0006672	biological_process	ceramide metabolic process
B	0008270	molecular_function	zinc ion binding
B	0008374	molecular_function	O-acyltransferase activity
B	0008970	molecular_function	phospholipase A1 activity
B	0009062	biological_process	fatty acid catabolic process
B	0016020	cellular_component	membrane
B	0016042	biological_process	lipid catabolic process
B	0016411	molecular_function	acylglycerol O-acyltransferase activity
B	0016746	molecular_function	acyltransferase activity
B	0016787	molecular_function	hydrolase activity
B	0034638	biological_process	phosphatidylcholine catabolic process
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0046338	biological_process	phosphatidylethanolamine catabolic process
B	0046470	biological_process	phosphatidylcholine metabolic process
B	0046471	biological_process	phosphatidylglycerol metabolic process
B	0046872	molecular_function	metal ion binding
B	0047499	molecular_function	calcium-independent phospholipase A2 activity
B	0052739	molecular_function	phosphatidylserine 1-acylhydrolase activity
B	0052740	molecular_function	1-acyl-2-lysophosphatidylserine acylhydrolase activity
B	0070062	cellular_component	extracellular exosome
B	0102545	molecular_function	phosphatidyl phospholipase B activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Acyl-ester intermediate => ECO:0000255, ECO:0000269|PubMed:25727495, ECO:0007744|PDB:4X97

Chain	Residue	Details
A	SER165
B	SER165

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site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Charge relay system => ECO:0000305|PubMed:25727495

Chain	Residue	Details
A	ASP327
A	HIS359
B	ASP327
B	HIS359

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000305|PubMed:25727495, ECO:0007744|PDB:4X97

Chain	Residue	Details
A	ASP13
B	ASP13

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site_id	SWS_FT_FI4
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:30830753

Chain	Residue	Details
A	SER165
A	ASP307
A	CYS322
A	HIS359
B	SER165
B	ASP307
B	CYS322
B	HIS359

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0000305|PubMed:25727495, ECO:0007744|PDB:4X95

Chain	Residue	Details
A	MET166
B	MET166

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site_id	SWS_FT_FI6
Number of Residues	8
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:25727495, ECO:0007744|PDB:4X90, ECO:0007744|PDB:4X91, ECO:0007744|PDB:4X92, ECO:0007744|PDB:4X93, ECO:0007744|PDB:4X94, ECO:0007744|PDB:4X95, ECO:0007744|PDB:4X97

Chain	Residue	Details
A	ASN66
A	ASN240
A	ASN256
A	ASN365
B	ASN66
B	ASN240
B	ASN256
B	ASN365

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