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6MT3

Crystal Structure of HLA-B*18:01 in complex with NP338 influenza peptide

Functional Information from GO Data
ChainGOidnamespacecontents
C0000139cellular_componentGolgi membrane
C0001913biological_processT cell mediated cytotoxicity
C0001916biological_processpositive regulation of T cell mediated cytotoxicity
C0002237biological_processresponse to molecule of bacterial origin
C0002376biological_processimmune system process
C0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
C0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
C0002502biological_processpeptide antigen assembly with MHC class I protein complex
C0002503biological_processpeptide antigen assembly with MHC class II protein complex
C0002726biological_processpositive regulation of T cell cytokine production
C0005198molecular_functionstructural molecule activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005765cellular_componentlysosomal membrane
C0005783cellular_componentendoplasmic reticulum
C0005788cellular_componentendoplasmic reticulum lumen
C0005794cellular_componentGolgi apparatus
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005925cellular_componentfocal adhesion
C0006826biological_processiron ion transport
C0006879biological_processintracellular iron ion homeostasis
C0006955biological_processimmune response
C0007608biological_processsensory perception of smell
C0007611biological_processlearning or memory
C0009897cellular_componentexternal side of plasma membrane
C0009986cellular_componentcell surface
C0010977biological_processnegative regulation of neuron projection development
C0012507cellular_componentER to Golgi transport vesicle membrane
C0016020cellular_componentmembrane
C0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
C0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
C0023026molecular_functionMHC class II protein complex binding
C0030670cellular_componentphagocytic vesicle membrane
C0031901cellular_componentearly endosome membrane
C0031902cellular_componentlate endosome membrane
C0031905cellular_componentearly endosome lumen
C0032092biological_processpositive regulation of protein binding
C0033077biological_processT cell differentiation in thymus
C0034756biological_processregulation of iron ion transport
C0035580cellular_componentspecific granule lumen
C0042026biological_processprotein refolding
C0042605molecular_functionpeptide antigen binding
C0042612cellular_componentMHC class I protein complex
C0042613cellular_componentMHC class II protein complex
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0042824cellular_componentMHC class I peptide loading complex
C0045646biological_processregulation of erythrocyte differentiation
C0048260biological_processpositive regulation of receptor-mediated endocytosis
C0050680biological_processnegative regulation of epithelial cell proliferation
C0050768biological_processnegative regulation of neurogenesis
C0050778biological_processpositive regulation of immune response
C0050870biological_processpositive regulation of T cell activation
C0051289biological_processprotein homotetramerization
C0055038cellular_componentrecycling endosome membrane
C0060586biological_processmulticellular organismal-level iron ion homeostasis
C0070062cellular_componentextracellular exosome
C0071281biological_processcellular response to iron ion
C0071283biological_processcellular response to iron(III) ion
C0071316biological_processcellular response to nicotine
C1900121biological_processnegative regulation of receptor binding
C1900122biological_processpositive regulation of receptor binding
C1904434biological_processpositive regulation of ferrous iron binding
C1904437biological_processpositive regulation of transferrin receptor binding
C1904724cellular_componenttertiary granule lumen
C1990000biological_processamyloid fibril formation
C1990712cellular_componentHFE-transferrin receptor complex
C2000774biological_processpositive regulation of cellular senescence
C2000978biological_processnegative regulation of forebrain neuron differentiation
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH
ChainResidueDetails
CTYR78-HIS84
ATYR257-HIS263

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
ChainResidueDetails
CGLN2
ATYR84
ATHR143
ALYS146
AVAL152
ATYR159
AHIS171

site_idSWS_FT_FI2
Number of Residues1
DetailsCARBOHYD: N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443
ChainResidueDetails
CILE1

site_idSWS_FT_FI3
Number of Residues6
DetailsCARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
ChainResidueDetails
CLYS19
CLYS41
CLYS48
CLYS58
CLYS91
CLYS94

218853

PDB entries from 2024-04-24

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