6MSB

Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0000502	cellular_component	proteasome complex
a	0005198	molecular_function	structural molecule activity
a	0005515	molecular_function	protein binding
a	0005576	cellular_component	extracellular region
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0005829	cellular_component	cytosol
a	0005838	cellular_component	proteasome regulatory particle
a	0006511	biological_process	ubiquitin-dependent protein catabolic process
a	0007127	biological_process	meiosis I
a	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
a	0016020	cellular_component	membrane
a	0022624	cellular_component	proteasome accessory complex
a	0034774	cellular_component	secretory granule lumen
a	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
a	1904813	cellular_component	ficolin-1-rich granule lumen
A	0000166	molecular_function	nucleotide binding
A	0000502	cellular_component	proteasome complex
A	0000932	cellular_component	P-body
A	0001649	biological_process	osteoblast differentiation
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0008540	cellular_component	proteasome regulatory particle, base subcomplex
A	0016020	cellular_component	membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0022624	cellular_component	proteasome accessory complex
A	0034774	cellular_component	secretory granule lumen
A	0036402	molecular_function	proteasome-activating activity
A	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	1901800	biological_process	positive regulation of proteasomal protein catabolic process
A	1904813	cellular_component	ficolin-1-rich granule lumen
b	0000502	cellular_component	proteasome complex
b	0003723	molecular_function	RNA binding
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005829	cellular_component	cytosol
b	0008540	cellular_component	proteasome regulatory particle, base subcomplex
b	0022624	cellular_component	proteasome accessory complex
b	0031593	molecular_function	polyubiquitin modification-dependent protein binding
b	0042802	molecular_function	identical protein binding
b	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
b	0060090	molecular_function	molecular adaptor activity
B	0000166	molecular_function	nucleotide binding
B	0000502	cellular_component	proteasome complex
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005838	cellular_component	proteasome regulatory particle
B	0008540	cellular_component	proteasome regulatory particle, base subcomplex
B	0016020	cellular_component	membrane
B	0016887	molecular_function	ATP hydrolysis activity
B	0022624	cellular_component	proteasome accessory complex
B	0036402	molecular_function	proteasome-activating activity
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	1901800	biological_process	positive regulation of proteasomal protein catabolic process
c	0000502	cellular_component	proteasome complex
c	0000724	biological_process	double-strand break repair via homologous recombination
c	0005515	molecular_function	protein binding
c	0005576	cellular_component	extracellular region
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0005829	cellular_component	cytosol
c	0006281	biological_process	DNA repair
c	0006303	biological_process	double-strand break repair via nonhomologous end joining
c	0006508	biological_process	proteolysis
c	0006511	biological_process	ubiquitin-dependent protein catabolic process
c	0006974	biological_process	DNA damage response
c	0008233	molecular_function	peptidase activity
c	0008237	molecular_function	metallopeptidase activity
c	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
c	0016579	biological_process	protein deubiquitination
c	0016787	molecular_function	hydrolase activity
c	0022624	cellular_component	proteasome accessory complex
c	0031597	cellular_component	cytosolic proteasome complex
c	0034774	cellular_component	secretory granule lumen
c	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
c	0045471	biological_process	response to ethanol
c	0046872	molecular_function	metal ion binding
c	0061133	molecular_function	endopeptidase activator activity
c	0061136	biological_process	regulation of proteasomal protein catabolic process
c	0061578	molecular_function	K63-linked deubiquitinase activity
c	0070536	biological_process	protein K63-linked deubiquitination
c	0070628	molecular_function	proteasome binding
c	0140492	molecular_function	metal-dependent deubiquitinase activity
c	1904813	cellular_component	ficolin-1-rich granule lumen
C	0000166	molecular_function	nucleotide binding
C	0000502	cellular_component	proteasome complex
C	0005102	molecular_function	signaling receptor binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005838	cellular_component	proteasome regulatory particle
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0008134	molecular_function	transcription factor binding
C	0008540	cellular_component	proteasome regulatory particle, base subcomplex
C	0016020	cellular_component	membrane
C	0016234	cellular_component	inclusion body
C	0016887	molecular_function	ATP hydrolysis activity
C	0017025	molecular_function	TBP-class protein binding
C	0022624	cellular_component	proteasome accessory complex
C	0031410	cellular_component	cytoplasmic vesicle
C	0031531	molecular_function	thyrotropin-releasing hormone receptor binding
C	0031595	cellular_component	nuclear proteasome complex
C	0031597	cellular_component	cytosolic proteasome complex
C	0036402	molecular_function	proteasome-activating activity
C	0043069	biological_process	negative regulation of programmed cell death
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0070062	cellular_component	extracellular exosome
C	0072562	cellular_component	blood microparticle
C	0090261	biological_process	positive regulation of inclusion body assembly
C	0140296	molecular_function	general transcription initiation factor binding
C	0140297	molecular_function	DNA-binding transcription factor binding
C	1901800	biological_process	positive regulation of proteasomal protein catabolic process
d	0000502	cellular_component	proteasome complex
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005654	cellular_component	nucleoplasm
d	0005829	cellular_component	cytosol
d	0005838	cellular_component	proteasome regulatory particle
d	0006508	biological_process	proteolysis
d	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
d	0022624	cellular_component	proteasome accessory complex
d	0032991	cellular_component	protein-containing complex
d	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0000166	molecular_function	nucleotide binding
D	0000502	cellular_component	proteasome complex
D	0001824	biological_process	blastocyst development
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006508	biological_process	proteolysis
D	0008540	cellular_component	proteasome regulatory particle, base subcomplex
D	0016020	cellular_component	membrane
D	0016887	molecular_function	ATP hydrolysis activity
D	0022624	cellular_component	proteasome accessory complex
D	0036064	cellular_component	ciliary basal body
D	0036402	molecular_function	proteasome-activating activity
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	1901800	biological_process	positive regulation of proteasomal protein catabolic process
e	0000502	cellular_component	proteasome complex
e	0000724	biological_process	double-strand break repair via homologous recombination
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005829	cellular_component	cytosol
e	0006406	biological_process	mRNA export from nucleus
e	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
e	0032039	cellular_component	integrator complex
e	0032991	cellular_component	protein-containing complex
e	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
e	0043248	biological_process	proteasome assembly
E	0000166	molecular_function	nucleotide binding
E	0000502	cellular_component	proteasome complex
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0008540	cellular_component	proteasome regulatory particle, base subcomplex
E	0016020	cellular_component	membrane
E	0016234	cellular_component	inclusion body
E	0016887	molecular_function	ATP hydrolysis activity
E	0022624	cellular_component	proteasome accessory complex
E	0030674	molecular_function	protein-macromolecule adaptor activity
E	0031597	cellular_component	cytosolic proteasome complex
E	0036402	molecular_function	proteasome-activating activity
E	0036503	biological_process	ERAD pathway
E	0042802	molecular_function	identical protein binding
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
E	0070062	cellular_component	extracellular exosome
E	0090261	biological_process	positive regulation of inclusion body assembly
E	1901800	biological_process	positive regulation of proteasomal protein catabolic process
f	0000502	cellular_component	proteasome complex
f	0005515	molecular_function	protein binding
f	0005576	cellular_component	extracellular region
f	0005634	cellular_component	nucleus
f	0005654	cellular_component	nucleoplasm
f	0005829	cellular_component	cytosol
f	0005838	cellular_component	proteasome regulatory particle
f	0008540	cellular_component	proteasome regulatory particle, base subcomplex
f	0016020	cellular_component	membrane
f	0022624	cellular_component	proteasome accessory complex
f	0030234	molecular_function	enzyme regulator activity
f	0034515	cellular_component	proteasome storage granule
f	0034774	cellular_component	secretory granule lumen
f	0042176	biological_process	regulation of protein catabolic process
f	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
f	0070062	cellular_component	extracellular exosome
f	1904813	cellular_component	ficolin-1-rich granule lumen
F	0000166	molecular_function	nucleotide binding
F	0000502	cellular_component	proteasome complex
F	0000932	cellular_component	P-body
F	0001824	biological_process	blastocyst development
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0008540	cellular_component	proteasome regulatory particle, base subcomplex
F	0016020	cellular_component	membrane
F	0016887	molecular_function	ATP hydrolysis activity
F	0022624	cellular_component	proteasome accessory complex
F	0034774	cellular_component	secretory granule lumen
F	0036402	molecular_function	proteasome-activating activity
F	0042802	molecular_function	identical protein binding
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0043921	biological_process	modulation by host of viral transcription
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	1901800	biological_process	positive regulation of proteasomal protein catabolic process
F	1904813	cellular_component	ficolin-1-rich granule lumen
g	0000502	cellular_component	proteasome complex
g	0000932	cellular_component	P-body
g	0003723	molecular_function	RNA binding
g	0004175	molecular_function	endopeptidase activity
g	0005515	molecular_function	protein binding
g	0005634	cellular_component	nucleus
g	0005654	cellular_component	nucleoplasm
g	0005737	cellular_component	cytoplasm
g	0005739	cellular_component	mitochondrion
g	0005829	cellular_component	cytosol
g	0005839	cellular_component	proteasome core complex
g	0005840	cellular_component	ribosome
g	0005929	cellular_component	cilium
g	0006511	biological_process	ubiquitin-dependent protein catabolic process
g	0016363	cellular_component	nuclear matrix
g	0019773	cellular_component	proteasome core complex, alpha-subunit complex
g	0030016	cellular_component	myofibril
g	0030017	cellular_component	sarcomere
g	0035639	molecular_function	purine ribonucleoside triphosphate binding
g	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
g	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
g	0050727	biological_process	regulation of inflammatory response
g	0051059	molecular_function	NF-kappaB binding
g	0051603	biological_process	proteolysis involved in protein catabolic process
g	0070062	cellular_component	extracellular exosome
G	0000502	cellular_component	proteasome complex
G	0000932	cellular_component	P-body
G	0003723	molecular_function	RNA binding
G	0004175	molecular_function	endopeptidase activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005829	cellular_component	cytosol
G	0005839	cellular_component	proteasome core complex
G	0005840	cellular_component	ribosome
G	0005929	cellular_component	cilium
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0016363	cellular_component	nuclear matrix
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0030016	cellular_component	myofibril
G	0030017	cellular_component	sarcomere
G	0035639	molecular_function	purine ribonucleoside triphosphate binding
G	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0050727	biological_process	regulation of inflammatory response
G	0051059	molecular_function	NF-kappaB binding
G	0051603	biological_process	proteolysis involved in protein catabolic process
G	0070062	cellular_component	extracellular exosome
h	0000502	cellular_component	proteasome complex
h	0000932	cellular_component	P-body
h	0005515	molecular_function	protein binding
h	0005576	cellular_component	extracellular region
h	0005634	cellular_component	nucleus
h	0005654	cellular_component	nucleoplasm
h	0005737	cellular_component	cytoplasm
h	0005829	cellular_component	cytosol
h	0005839	cellular_component	proteasome core complex
h	0006511	biological_process	ubiquitin-dependent protein catabolic process
h	0009615	biological_process	response to virus
h	0019773	cellular_component	proteasome core complex, alpha-subunit complex
h	0034774	cellular_component	secretory granule lumen
h	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
h	0051603	biological_process	proteolysis involved in protein catabolic process
h	0070062	cellular_component	extracellular exosome
h	1904813	cellular_component	ficolin-1-rich granule lumen
H	0000502	cellular_component	proteasome complex
H	0000932	cellular_component	P-body
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005839	cellular_component	proteasome core complex
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
H	0009615	biological_process	response to virus
H	0019773	cellular_component	proteasome core complex, alpha-subunit complex
H	0034774	cellular_component	secretory granule lumen
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0051603	biological_process	proteolysis involved in protein catabolic process
H	0070062	cellular_component	extracellular exosome
H	1904813	cellular_component	ficolin-1-rich granule lumen
i	0000502	cellular_component	proteasome complex
i	0000932	cellular_component	P-body
i	0005515	molecular_function	protein binding
i	0005634	cellular_component	nucleus
i	0005654	cellular_component	nucleoplasm
i	0005737	cellular_component	cytoplasm
i	0005829	cellular_component	cytosol
i	0005839	cellular_component	proteasome core complex
i	0006511	biological_process	ubiquitin-dependent protein catabolic process
i	0019773	cellular_component	proteasome core complex, alpha-subunit complex
i	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
i	0051603	biological_process	proteolysis involved in protein catabolic process
i	0070062	cellular_component	extracellular exosome
I	0000502	cellular_component	proteasome complex
I	0000932	cellular_component	P-body
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005839	cellular_component	proteasome core complex
I	0006511	biological_process	ubiquitin-dependent protein catabolic process
I	0019773	cellular_component	proteasome core complex, alpha-subunit complex
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0051603	biological_process	proteolysis involved in protein catabolic process
I	0070062	cellular_component	extracellular exosome
j	0000502	cellular_component	proteasome complex
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0005654	cellular_component	nucleoplasm
j	0005737	cellular_component	cytoplasm
j	0005829	cellular_component	cytosol
j	0005839	cellular_component	proteasome core complex
j	0006511	biological_process	ubiquitin-dependent protein catabolic process
j	0019773	cellular_component	proteasome core complex, alpha-subunit complex
j	0042802	molecular_function	identical protein binding
j	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
j	0051603	biological_process	proteolysis involved in protein catabolic process
j	0070062	cellular_component	extracellular exosome
J	0000502	cellular_component	proteasome complex
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005839	cellular_component	proteasome core complex
J	0006511	biological_process	ubiquitin-dependent protein catabolic process
J	0019773	cellular_component	proteasome core complex, alpha-subunit complex
J	0042802	molecular_function	identical protein binding
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0051603	biological_process	proteolysis involved in protein catabolic process
J	0070062	cellular_component	extracellular exosome
k	0000502	cellular_component	proteasome complex
k	0005515	molecular_function	protein binding
k	0005576	cellular_component	extracellular region
k	0005634	cellular_component	nucleus
k	0005654	cellular_component	nucleoplasm
k	0005737	cellular_component	cytoplasm
k	0005829	cellular_component	cytosol
k	0005839	cellular_component	proteasome core complex
k	0006511	biological_process	ubiquitin-dependent protein catabolic process
k	0019773	cellular_component	proteasome core complex, alpha-subunit complex
k	0034774	cellular_component	secretory granule lumen
k	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
k	0051603	biological_process	proteolysis involved in protein catabolic process
k	0070062	cellular_component	extracellular exosome
k	1904813	cellular_component	ficolin-1-rich granule lumen
K	0000502	cellular_component	proteasome complex
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005839	cellular_component	proteasome core complex
K	0006511	biological_process	ubiquitin-dependent protein catabolic process
K	0019773	cellular_component	proteasome core complex, alpha-subunit complex
K	0034774	cellular_component	secretory granule lumen
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0051603	biological_process	proteolysis involved in protein catabolic process
K	0070062	cellular_component	extracellular exosome
K	1904813	cellular_component	ficolin-1-rich granule lumen
l	0000502	cellular_component	proteasome complex
l	0001530	molecular_function	lipopolysaccharide binding
l	0002376	biological_process	immune system process
l	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
l	0005515	molecular_function	protein binding
l	0005634	cellular_component	nucleus
l	0005654	cellular_component	nucleoplasm
l	0005737	cellular_component	cytoplasm
l	0005813	cellular_component	centrosome
l	0005829	cellular_component	cytosol
l	0005839	cellular_component	proteasome core complex
l	0006511	biological_process	ubiquitin-dependent protein catabolic process
l	0019773	cellular_component	proteasome core complex, alpha-subunit complex
l	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
l	0051603	biological_process	proteolysis involved in protein catabolic process
l	0070062	cellular_component	extracellular exosome
L	0000502	cellular_component	proteasome complex
L	0001530	molecular_function	lipopolysaccharide binding
L	0002376	biological_process	immune system process
L	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005813	cellular_component	centrosome
L	0005829	cellular_component	cytosol
L	0005839	cellular_component	proteasome core complex
L	0006511	biological_process	ubiquitin-dependent protein catabolic process
L	0019773	cellular_component	proteasome core complex, alpha-subunit complex
L	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
L	0051603	biological_process	proteolysis involved in protein catabolic process
L	0070062	cellular_component	extracellular exosome
m	0000502	cellular_component	proteasome complex
m	0005515	molecular_function	protein binding
m	0005634	cellular_component	nucleus
m	0005654	cellular_component	nucleoplasm
m	0005737	cellular_component	cytoplasm
m	0005829	cellular_component	cytosol
m	0005839	cellular_component	proteasome core complex
m	0006511	biological_process	ubiquitin-dependent protein catabolic process
m	0019773	cellular_component	proteasome core complex, alpha-subunit complex
m	0031625	molecular_function	ubiquitin protein ligase binding
m	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
m	0051603	biological_process	proteolysis involved in protein catabolic process
m	0070062	cellular_component	extracellular exosome
M	0000502	cellular_component	proteasome complex
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0005839	cellular_component	proteasome core complex
M	0006511	biological_process	ubiquitin-dependent protein catabolic process
M	0019773	cellular_component	proteasome core complex, alpha-subunit complex
M	0031625	molecular_function	ubiquitin protein ligase binding
M	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
M	0051603	biological_process	proteolysis involved in protein catabolic process
M	0070062	cellular_component	extracellular exosome
n	0000502	cellular_component	proteasome complex
n	0004175	molecular_function	endopeptidase activity
n	0004298	molecular_function	threonine-type endopeptidase activity
n	0005515	molecular_function	protein binding
n	0005634	cellular_component	nucleus
n	0005654	cellular_component	nucleoplasm
n	0005737	cellular_component	cytoplasm
n	0005739	cellular_component	mitochondrion
n	0005829	cellular_component	cytosol
n	0005839	cellular_component	proteasome core complex
n	0006508	biological_process	proteolysis
n	0008233	molecular_function	peptidase activity
n	0016787	molecular_function	hydrolase activity
n	0019774	cellular_component	proteasome core complex, beta-subunit complex
n	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
n	0045296	molecular_function	cadherin binding
n	0051603	biological_process	proteolysis involved in protein catabolic process
n	0070062	cellular_component	extracellular exosome
N	0000502	cellular_component	proteasome complex
N	0004175	molecular_function	endopeptidase activity
N	0004298	molecular_function	threonine-type endopeptidase activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005737	cellular_component	cytoplasm
N	0005739	cellular_component	mitochondrion
N	0005829	cellular_component	cytosol
N	0005839	cellular_component	proteasome core complex
N	0006508	biological_process	proteolysis
N	0008233	molecular_function	peptidase activity
N	0016787	molecular_function	hydrolase activity
N	0019774	cellular_component	proteasome core complex, beta-subunit complex
N	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
N	0045296	molecular_function	cadherin binding
N	0051603	biological_process	proteolysis involved in protein catabolic process
N	0070062	cellular_component	extracellular exosome
o	0000502	cellular_component	proteasome complex
o	0004175	molecular_function	endopeptidase activity
o	0004298	molecular_function	threonine-type endopeptidase activity
o	0005515	molecular_function	protein binding
o	0005576	cellular_component	extracellular region
o	0005634	cellular_component	nucleus
o	0005654	cellular_component	nucleoplasm
o	0005737	cellular_component	cytoplasm
o	0005829	cellular_component	cytosol
o	0005839	cellular_component	proteasome core complex
o	0005929	cellular_component	cilium
o	0006508	biological_process	proteolysis
o	0008233	molecular_function	peptidase activity
o	0016604	cellular_component	nuclear body
o	0016787	molecular_function	hydrolase activity
o	0019774	cellular_component	proteasome core complex, beta-subunit complex
o	0034774	cellular_component	secretory granule lumen
o	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
o	0051603	biological_process	proteolysis involved in protein catabolic process
o	1904813	cellular_component	ficolin-1-rich granule lumen
O	0000502	cellular_component	proteasome complex
O	0004175	molecular_function	endopeptidase activity
O	0004298	molecular_function	threonine-type endopeptidase activity
O	0005515	molecular_function	protein binding
O	0005576	cellular_component	extracellular region
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005839	cellular_component	proteasome core complex
O	0005929	cellular_component	cilium
O	0006508	biological_process	proteolysis
O	0008233	molecular_function	peptidase activity
O	0016604	cellular_component	nuclear body
O	0016787	molecular_function	hydrolase activity
O	0019774	cellular_component	proteasome core complex, beta-subunit complex
O	0034774	cellular_component	secretory granule lumen
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	0051603	biological_process	proteolysis involved in protein catabolic process
O	1904813	cellular_component	ficolin-1-rich granule lumen
p	0000502	cellular_component	proteasome complex
p	0005515	molecular_function	protein binding
p	0005634	cellular_component	nucleus
p	0005654	cellular_component	nucleoplasm
p	0005737	cellular_component	cytoplasm
p	0005829	cellular_component	cytosol
p	0005839	cellular_component	proteasome core complex
p	0019774	cellular_component	proteasome core complex, beta-subunit complex
p	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
p	0051603	biological_process	proteolysis involved in protein catabolic process
p	0070062	cellular_component	extracellular exosome
P	0000502	cellular_component	proteasome complex
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005839	cellular_component	proteasome core complex
P	0019774	cellular_component	proteasome core complex, beta-subunit complex
P	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
P	0051603	biological_process	proteolysis involved in protein catabolic process
P	0070062	cellular_component	extracellular exosome
q	0000502	cellular_component	proteasome complex
q	0005515	molecular_function	protein binding
q	0005634	cellular_component	nucleus
q	0005654	cellular_component	nucleoplasm
q	0005737	cellular_component	cytoplasm
q	0005829	cellular_component	cytosol
q	0005839	cellular_component	proteasome core complex
q	0010498	biological_process	proteasomal protein catabolic process
q	0016020	cellular_component	membrane
q	0019774	cellular_component	proteasome core complex, beta-subunit complex
q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
q	0051603	biological_process	proteolysis involved in protein catabolic process
q	0070062	cellular_component	extracellular exosome
Q	0000502	cellular_component	proteasome complex
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0005839	cellular_component	proteasome core complex
Q	0010498	biological_process	proteasomal protein catabolic process
Q	0016020	cellular_component	membrane
Q	0019774	cellular_component	proteasome core complex, beta-subunit complex
Q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Q	0051603	biological_process	proteolysis involved in protein catabolic process
Q	0070062	cellular_component	extracellular exosome
r	0000502	cellular_component	proteasome complex
r	0004175	molecular_function	endopeptidase activity
r	0004298	molecular_function	threonine-type endopeptidase activity
r	0005515	molecular_function	protein binding
r	0005634	cellular_component	nucleus
r	0005654	cellular_component	nucleoplasm
r	0005737	cellular_component	cytoplasm
r	0005813	cellular_component	centrosome
r	0005829	cellular_component	cytosol
r	0005839	cellular_component	proteasome core complex
r	0006508	biological_process	proteolysis
r	0006979	biological_process	response to oxidative stress
r	0008233	molecular_function	peptidase activity
r	0016787	molecular_function	hydrolase activity
r	0019774	cellular_component	proteasome core complex, beta-subunit complex
r	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
r	0043248	biological_process	proteasome assembly
r	0051603	biological_process	proteolysis involved in protein catabolic process
r	0070062	cellular_component	extracellular exosome
R	0000502	cellular_component	proteasome complex
R	0004175	molecular_function	endopeptidase activity
R	0004298	molecular_function	threonine-type endopeptidase activity
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005813	cellular_component	centrosome
R	0005829	cellular_component	cytosol
R	0005839	cellular_component	proteasome core complex
R	0006508	biological_process	proteolysis
R	0006979	biological_process	response to oxidative stress
R	0008233	molecular_function	peptidase activity
R	0016787	molecular_function	hydrolase activity
R	0019774	cellular_component	proteasome core complex, beta-subunit complex
R	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
R	0043248	biological_process	proteasome assembly
R	0051603	biological_process	proteolysis involved in protein catabolic process
R	0070062	cellular_component	extracellular exosome
s	0000502	cellular_component	proteasome complex
s	0005515	molecular_function	protein binding
s	0005576	cellular_component	extracellular region
s	0005634	cellular_component	nucleus
s	0005654	cellular_component	nucleoplasm
s	0005737	cellular_component	cytoplasm
s	0005829	cellular_component	cytosol
s	0005839	cellular_component	proteasome core complex
s	0019774	cellular_component	proteasome core complex, beta-subunit complex
s	0034774	cellular_component	secretory granule lumen
s	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
s	0051603	biological_process	proteolysis involved in protein catabolic process
s	0070062	cellular_component	extracellular exosome
s	1904813	cellular_component	ficolin-1-rich granule lumen
S	0000502	cellular_component	proteasome complex
S	0005515	molecular_function	protein binding
S	0005576	cellular_component	extracellular region
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0005839	cellular_component	proteasome core complex
S	0019774	cellular_component	proteasome core complex, beta-subunit complex
S	0034774	cellular_component	secretory granule lumen
S	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
S	0051603	biological_process	proteolysis involved in protein catabolic process
S	0070062	cellular_component	extracellular exosome
S	1904813	cellular_component	ficolin-1-rich granule lumen
t	0000502	cellular_component	proteasome complex
t	0001530	molecular_function	lipopolysaccharide binding
t	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
t	0005515	molecular_function	protein binding
t	0005634	cellular_component	nucleus
t	0005654	cellular_component	nucleoplasm
t	0005737	cellular_component	cytoplasm
t	0005739	cellular_component	mitochondrion
t	0005829	cellular_component	cytosol
t	0005839	cellular_component	proteasome core complex
t	0019774	cellular_component	proteasome core complex, beta-subunit complex
t	0036064	cellular_component	ciliary basal body
t	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
t	0051603	biological_process	proteolysis involved in protein catabolic process
t	0070062	cellular_component	extracellular exosome
T	0000502	cellular_component	proteasome complex
T	0001530	molecular_function	lipopolysaccharide binding
T	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005737	cellular_component	cytoplasm
T	0005739	cellular_component	mitochondrion
T	0005829	cellular_component	cytosol
T	0005839	cellular_component	proteasome core complex
T	0019774	cellular_component	proteasome core complex, beta-subunit complex
T	0036064	cellular_component	ciliary basal body
T	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
T	0051603	biological_process	proteolysis involved in protein catabolic process
T	0070062	cellular_component	extracellular exosome
U	0000502	cellular_component	proteasome complex
U	0005515	molecular_function	protein binding
U	0005576	cellular_component	extracellular region
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005829	cellular_component	cytosol
U	0005838	cellular_component	proteasome regulatory particle
U	0008540	cellular_component	proteasome regulatory particle, base subcomplex
U	0016020	cellular_component	membrane
U	0022624	cellular_component	proteasome accessory complex
U	0030234	molecular_function	enzyme regulator activity
U	0031625	molecular_function	ubiquitin protein ligase binding
U	0034515	cellular_component	proteasome storage granule
U	0035578	cellular_component	azurophil granule lumen
U	0042176	biological_process	regulation of protein catabolic process
U	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
V	0000502	cellular_component	proteasome complex
V	0005515	molecular_function	protein binding
V	0005576	cellular_component	extracellular region
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005829	cellular_component	cytosol
V	0005838	cellular_component	proteasome regulatory particle
V	0006511	biological_process	ubiquitin-dependent protein catabolic process
V	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
V	0016020	cellular_component	membrane
V	0022624	cellular_component	proteasome accessory complex
V	0030234	molecular_function	enzyme regulator activity
V	0034774	cellular_component	secretory granule lumen
V	0042176	biological_process	regulation of protein catabolic process
V	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
V	0070062	cellular_component	extracellular exosome
V	1904813	cellular_component	ficolin-1-rich granule lumen
W	0000502	cellular_component	proteasome complex
W	0005515	molecular_function	protein binding
W	0005576	cellular_component	extracellular region
W	0005654	cellular_component	nucleoplasm
W	0005737	cellular_component	cytoplasm
W	0005829	cellular_component	cytosol
W	0005838	cellular_component	proteasome regulatory particle
W	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
W	0016020	cellular_component	membrane
W	0022624	cellular_component	proteasome accessory complex
W	0034774	cellular_component	secretory granule lumen
W	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
W	0070062	cellular_component	extracellular exosome
W	1904813	cellular_component	ficolin-1-rich granule lumen
X	0000502	cellular_component	proteasome complex
X	0005198	molecular_function	structural molecule activity
X	0005515	molecular_function	protein binding
X	0005576	cellular_component	extracellular region
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0005838	cellular_component	proteasome regulatory particle
X	0006511	biological_process	ubiquitin-dependent protein catabolic process
X	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
X	0016020	cellular_component	membrane
X	0022624	cellular_component	proteasome accessory complex
X	0032991	cellular_component	protein-containing complex
X	0034774	cellular_component	secretory granule lumen
X	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
X	0043248	biological_process	proteasome assembly
X	0048863	biological_process	stem cell differentiation
X	1904813	cellular_component	ficolin-1-rich granule lumen
Y	0000502	cellular_component	proteasome complex
Y	0005515	molecular_function	protein binding
Y	0005576	cellular_component	extracellular region
Y	0005654	cellular_component	nucleoplasm
Y	0005829	cellular_component	cytosol
Y	0005838	cellular_component	proteasome regulatory particle
Y	0022624	cellular_component	proteasome accessory complex
Y	0032991	cellular_component	protein-containing complex
Y	0034774	cellular_component	secretory granule lumen
Y	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Y	1904813	cellular_component	ficolin-1-rich granule lumen
Z	0000502	cellular_component	proteasome complex
Z	0005515	molecular_function	protein binding
Z	0005576	cellular_component	extracellular region
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0005829	cellular_component	cytosol
Z	0005838	cellular_component	proteasome regulatory particle
Z	0008233	molecular_function	peptidase activity
Z	0008237	molecular_function	metallopeptidase activity
Z	0016020	cellular_component	membrane
Z	0034774	cellular_component	secretory granule lumen
Z	0042803	molecular_function	protein homodimerization activity
Z	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Z	0070062	cellular_component	extracellular exosome
Z	0140492	molecular_function	metal-dependent deubiquitinase activity
Z	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN c 401

Chain	Residue
c	GLU52
c	HIS113
c	HIS115
c	ASP126

---

site_id	AC2
Number of Residues	14
Details	binding site for residue ATP A 501

Chain	Residue
A	GLY221
A	LYS222
A	THR223
A	LEU224
A	HIS358
A	MG502
B	ASP317
B	ARG343
B	ARG346
A	ASP176
A	GLY178
A	PRO218
A	GLY219
A	THR220

---

site_id	AC3
Number of Residues	2
Details	binding site for residue MG A 502

Chain	Residue
A	THR223
A	ATP501

---

site_id	AC4
Number of Residues	14
Details	binding site for residue ATP B 501

Chain	Residue
B	ILE187
B	PRO228
B	GLY229
B	THR230
B	GLY231
B	LYS232
B	THR233
B	LEU234
B	HIS368
B	GLY392
B	ALA393
B	LYS396
B	MG502
C	ARG307

---

site_id	AC5
Number of Residues	2
Details	binding site for residue MG B 502

Chain	Residue
B	THR233
B	ATP501

---

site_id	AC6
Number of Residues	11
Details	binding site for residue ADP C 501

Chain	Residue
C	MET150
C	GLY152
C	PRO192
C	GLY193
C	THR194
C	GLY195
C	LYS196
C	THR197
C	LEU198
C	GLY356
C	LYS360

---

site_id	AC7
Number of Residues	15
Details	binding site for residue ATP D 501

Chain	Residue
D	ILE167
D	GLY168
D	PRO208
D	GLY209
D	CYS210
D	GLY211
D	LYS212
D	THR213
D	MET214
D	GLY372
D	ALA373
D	ASN376
D	MG502
E	ARG291
E	ARG294

---

site_id	AC8
Number of Residues	2
Details	binding site for residue MG D 502

Chain	Residue
D	THR213
D	ATP501

---

site_id	AC9
Number of Residues	17
Details	binding site for residue ATP E 401

Chain	Residue
E	ILE135
E	GLY136
E	PRO176
E	GLY177
E	THR178
E	GLY179
E	LYS180
E	THR181
E	LEU182
E	ASN280
E	ILE312
E	HIS316
E	GLY340
E	ALA341
E	MG402
F	ARG344
F	ARG347

---

site_id	AD1
Number of Residues	2
Details	binding site for residue MG E 402

Chain	Residue
E	THR181
E	ATP401

---

site_id	AD2
Number of Residues	14
Details	binding site for residue ADP F 501

Chain	Residue
F	ILE188
F	GLY189
F	PRO229
F	GLY230
F	THR231
F	GLY232
F	LYS233
F	THR234
F	LEU235
F	ILE365
F	HIS369
F	GLY393
F	LYS397
F	MG502

---

site_id	AD3
Number of Residues	3
Details	binding site for residue MG F 502

Chain	Residue
F	ADP501
F	THR234
F	ASP286

---

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. AAGFSSSGPAATSGAV

Chain	Residue	Details
d	ALA-21-VAL-6

---

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
u	LYS27-ASP52

---

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. FdrhiTiFSPeGRlyQVEYAfkA

Chain	Residue	Details
g	PHE9-ALA31
h	TYR6-ALA28
j	TYR3-ALA25
k	TYR8-ALA30
M	TYR7-ALA29
i	TYR5-ALA27
l	TYR6-ALA28

---

site_id	PS00674
Number of Residues	19
Details	AAA AAA-protein family signature. IkVLmATNrpdtLDpALm.R

Chain	Residue	Details
A	ILE315-ARG333
E	VAL273-ARG291
F	VAL326-ARG344
C	ILE289-ARG307
D	VAL305-ARG323
B	VAL325-ARG343

---

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. IGIqGpdYVLVASDrvaasnivqmkddhd.KmfkmsekilllcvGeaGD

Chain	Residue	Details
Q	ILE5-ASP52
S	LEU13-ASP60
N	MET4-ASP51
O	ALA4-ASP51
P	MET12-ASP59
T	LEU12-ASP59
i	LEU35-ASP82
R	LEU4-ASP51

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
E	GLY174
t	SER-19
S	SER134
s	SER34
s	SER40
s	SER134

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
E	LYS72
E	LYS206
M	LYS229
m	LYS56
m	LYS205
m	LYS229

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
E	SER244
s	LYS176
i	LYS127
i	LYS176
h	SER14
h	SER16

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250

Chain	Residue	Details
S	SER30
S	SER181
s	SER30
s	SER181
l	LYS208

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250

Chain	Residue	Details
K	SER198
k	SER198
h	LYS70
h	LYS171

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
H	TYR76
h	TYR76

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P17220

Chain	Residue	Details
H	TYR121
h	TYR121
w	GLY76

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144

Chain	Residue	Details
u	LYS11
u	LYS48
w	LYS11
w	LYS48

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860

Chain	Residue	Details
u	LYS27
w	LYS27

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127

Chain	Residue	Details
u	LYS29
w	LYS29

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577

Chain	Residue	Details
u	LYS33
w	LYS33

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106

Chain	Residue	Details
u	ARG63
w	ARG63

---