6MRJ

Crystal structure of H.pylori NikR in complex with DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0001217	molecular_function	DNA-binding transcription repressor activity
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0010045	biological_process	response to nickel cation
A	0016151	molecular_function	nickel cation binding
A	0032993	cellular_component	protein-DNA complex
A	0042802	molecular_function	identical protein binding
A	0043565	molecular_function	sequence-specific DNA binding
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0046872	molecular_function	metal ion binding
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0001217	molecular_function	DNA-binding transcription repressor activity
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0006355	biological_process	regulation of DNA-templated transcription
B	0010045	biological_process	response to nickel cation
B	0016151	molecular_function	nickel cation binding
B	0032993	cellular_component	protein-DNA complex
B	0042802	molecular_function	identical protein binding
B	0043565	molecular_function	sequence-specific DNA binding
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0046872	molecular_function	metal ion binding
C	0000976	molecular_function	transcription cis-regulatory region binding
C	0001217	molecular_function	DNA-binding transcription repressor activity
C	0003677	molecular_function	DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0006355	biological_process	regulation of DNA-templated transcription
C	0010045	biological_process	response to nickel cation
C	0016151	molecular_function	nickel cation binding
C	0032993	cellular_component	protein-DNA complex
C	0042802	molecular_function	identical protein binding
C	0043565	molecular_function	sequence-specific DNA binding
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0046872	molecular_function	metal ion binding
D	0000976	molecular_function	transcription cis-regulatory region binding
D	0001217	molecular_function	DNA-binding transcription repressor activity
D	0003677	molecular_function	DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0006355	biological_process	regulation of DNA-templated transcription
D	0010045	biological_process	response to nickel cation
D	0016151	molecular_function	nickel cation binding
D	0032993	cellular_component	protein-DNA complex
D	0042802	molecular_function	identical protein binding
D	0043565	molecular_function	sequence-specific DNA binding
D	0045892	biological_process	negative regulation of DNA-templated transcription
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue NI A 201

Chain	Residue
A	HIS99
A	HIS101
A	CYS107
D	HIS88

---

site_id	AC2
Number of Residues	5
Details	binding site for residue MG A 202

Chain	Residue
A	GLY128
A	LEU130
A	VAL133
B	GLU39
B	ASP43

---

site_id	AC3
Number of Residues	5
Details	binding site for residue NI A 203

Chain	Residue
A	ILE84
A	HIS88
D	HIS99
D	HIS101
D	CYS107

---

site_id	AC4
Number of Residues	5
Details	binding site for residue NI B 201

Chain	Residue
B	HIS99
B	HIS101
B	CYS107
C	ILE84
C	HIS88

---

site_id	AC5
Number of Residues	5
Details	binding site for residue NI B 202

Chain	Residue
B	ILE84
B	HIS88
C	HIS99
C	HIS101
C	CYS107

---

site_id	AC6
Number of Residues	5
Details	binding site for residue MG C 201

Chain	Residue
C	GLU39
C	ASP43
D	GLY128
D	LEU130
D	VAL133

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00476

Chain	Residue	Details
A	HIS88
C	HIS99
C	HIS101
C	CYS107
D	HIS88
D	HIS99
D	HIS101
D	CYS107
A	HIS99
A	HIS101
A	CYS107
B	HIS88
B	HIS99
B	HIS101
B	CYS107
C	HIS88

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