6MOA
C-terminal bromodomain of human BRD2 in complex with 4-(2-cyclopropyl-7-(6-methylquinolin-5-yl)-1H-benzo[d]imidazol-5-yl)-3,5-dimethylisoxazole inhibitor
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue JW4 A 501 |
| Chain | Residue |
| A | TRP370 |
| A | HOH657 |
| A | HOH665 |
| A | PRO371 |
| A | PHE372 |
| A | LEU381 |
| A | LEU383 |
| A | ASN429 |
| A | HIS433 |
| A | HOH604 |
| A | HOH655 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 502 |
| Chain | Residue |
| A | TYR368 |
| A | LYS402 |
| A | ASP407 |
| A | MET438 |
| A | LYS441 |
| A | HOH601 |
| A | HOH613 |
| A | HOH626 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 60 |
| Details | BROMODOMAIN_1 Bromodomain signature. AwpFykpvDasalglhDYHdiIkhpMdlstVkrkmenrd..Yrdaqefaadvrl.MfsNCykY |
| Chain | Residue | Details |
| A | ALA369-TYR428 |
