6MLC

PHD6 domain of MLL3 in complex with histone H4

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0000786	cellular_component	nucleosome
E	0003677	molecular_function	DNA binding
F	0000786	cellular_component	nucleosome
F	0003677	molecular_function	DNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 2001

Chain	Residue
A	CYS1069
A	CYS1078
A	CYS1081
B	HIS1059

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 2002

Chain	Residue
A	CYS1087
A	CYS1090
A	HIS1111
A	CYS1114

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 2003

Chain	Residue
A	CYS1106
A	CYS1133
A	CYS1136
A	CYS1103

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN A 2004

Chain	Residue
A	CYS1057
A	CYS1060
B	CYS1057
B	CYS1060

---

site_id	AC5
Number of Residues	6
Details	binding site for residue GOL A 2005

Chain	Residue
A	CYS1057
A	GLY1066
A	CYS1081
A	HOH2101
A	HOH2102
B	HIS1059

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN A 2008

Chain	Residue
A	HIS1059
B	CYS1069
B	CYS1078
B	CYS1081

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN B 1201

Chain	Residue
B	CYS1087
B	CYS1090
B	HIS1111
B	CYS1114

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN B 1202

Chain	Residue
B	CYS1103
B	CYS1106
B	CYS1133
B	CYS1136

---

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN C 2001

Chain	Residue
C	CYS1069
C	CYS1078
C	CYS1081
D	HIS1059

---

site_id	AD1
Number of Residues	4
Details	binding site for residue ZN C 2002

Chain	Residue
C	CYS1087
C	CYS1090
C	HIS1111
C	CYS1114

---

site_id	AD2
Number of Residues	4
Details	binding site for residue ZN C 2003

Chain	Residue
C	CYS1103
C	CYS1106
C	CYS1133
C	CYS1136

---

site_id	AD3
Number of Residues	4
Details	binding site for residue ZN C 2004

Chain	Residue
C	CYS1057
C	CYS1060
D	CYS1057
D	CYS1060

---

site_id	AD4
Number of Residues	8
Details	binding site for residue GOL C 2005

Chain	Residue
C	GLN1102
C	ALA1127
C	GLY1130
C	PHE1131
C	GOL2006
C	HOH2103
D	GLN1072
F	GLY1514

---

site_id	AD5
Number of Residues	8
Details	binding site for residue GOL C 2006

Chain	Residue
C	ASN1073
C	THR1076
C	ARG1104
C	ASP1128
C	GOL2005
C	HOH2104
D	TYR1075
D	ARG1104

---

site_id	AD6
Number of Residues	4
Details	binding site for residue ZN C 2008

Chain	Residue
C	HIS1059
D	CYS1069
D	CYS1078
D	CYS1081

---

site_id	AD7
Number of Residues	4
Details	binding site for residue ZN D 1201

Chain	Residue
D	CYS1087
D	CYS1090
D	HIS1111
D	CYS1114

---

site_id	AD8
Number of Residues	4
Details	binding site for residue ZN D 1202

Chain	Residue
D	CYS1103
D	CYS1106
D	CYS1133
D	CYS1136

---

site_id	AD9
Number of Residues	9
Details	binding site for residue GOL D 1203

Chain	Residue
C	TRP1056
C	ARG1058
D	GLU1070
D	TRP1071
D	GLN1072
D	ASN1073
D	ASN1074
D	HOH2101
D	HOH2125

---

site_id	AE1
Number of Residues	8
Details	binding site for residue GOL D 1204

Chain	Residue
C	HIS1059
C	CYS1060
C	HOH2101
D	CYS1057
D	GLY1066
D	LEU1067
D	CYS1081
D	LEU1084

---

Functional Information from PROSITE/UniProt

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
E	GLY1514-HIS1518

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	DNA_BIND:

Chain	Residue	Details
E	LYS1516-LYS1520
F	LYS1516-LYS1520
C	LEU1084-TYR1139
D	LEU1084-TYR1139

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:17967882

Chain	Residue	Details
E	SER1501
F	SER1501

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Symmetric dimethylarginine; by PRMT5 and PRMT7; alternate => ECO:0000250|UniProtKB:P62806

Chain	Residue	Details
E	ARG1503
F	ARG1503

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-lactoyllysine; alternate => ECO:0000269|PubMed:31645732

Chain	Residue	Details
E	LYS1505
F	LYS1505

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: N6-propionyllysine; alternate => ECO:0000269|PubMed:17267393

Chain	Residue	Details
E	LYS1508
E	LYS1516
F	LYS1508
F	LYS1516

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435

Chain	Residue	Details
E	LYS1512
F	LYS1512

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:12086618, ECO:0000269|PubMed:15964846, ECO:0000269|PubMed:17967882, ECO:0000269|PubMed:27338793

Chain	Residue	Details
E	LYS1520
F	LYS1520

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25218447

Chain	Residue	Details
E	LYS1512
F	LYS1512

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733

Chain	Residue	Details
E	LYS1520
F	LYS1520

---