Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

6MKL

X-ray crystal structure of darunavir-resistant-P51 HIV-1 protease in complex with GRL-142

Functional Information from GO Data
ChainGOidnamespacecontents
A0004190molecular_functionaspartic-type endopeptidase activity
A0006508biological_processproteolysis
A0008233molecular_functionpeptidase activity
A0016787molecular_functionhydrolase activity
A0044174cellular_componenthost cell endosome
A0055036cellular_componentvirion membrane
A0072494cellular_componenthost multivesicular body
B0004190molecular_functionaspartic-type endopeptidase activity
B0006508biological_processproteolysis
B0008233molecular_functionpeptidase activity
B0016787molecular_functionhydrolase activity
B0044174cellular_componenthost cell endosome
B0055036cellular_componentvirion membrane
B0072494cellular_componenthost multivesicular body
Functional Information from PDB Data
site_idAC1
Number of Residues28
Detailsbinding site for residue 7OA A 400
ChainResidue
AARG8
AGLY49
AILE50
APRO81
AILE82
AHOH507
AHOH572
BARG8
BASP25
BGLY27
BALA28
AASP25
BASP29
BASP30
BILE32
BILE47
BGLY48
BGLY49
BILE50
BPRO81
BILE82
AGLY27
AALA28
AASP29
AASP30
AILE32
AILE47
AGLY48

Functional Information from PROSITE/UniProt
site_idPS00141
Number of Residues12
DetailsASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALIDTGADDTIF
ChainResidueDetails
AALA22-PHE33

239492

PDB entries from 2025-07-30

PDB statisticsPDBj update infoContact PDBjnumon