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6MK9

X-ray crystal structure of darunavir-resistant-P51 HIV-1 protease in complex with GRL-121

Functional Information from GO Data
ChainGOidnamespacecontents
A0004190molecular_functionaspartic-type endopeptidase activity
A0006508biological_processproteolysis
A0008233molecular_functionpeptidase activity
A0016787molecular_functionhydrolase activity
A0044174cellular_componenthost cell endosome
A0055036cellular_componentvirion membrane
A0072494cellular_componenthost multivesicular body
B0004190molecular_functionaspartic-type endopeptidase activity
B0006508biological_processproteolysis
B0008233molecular_functionpeptidase activity
B0016787molecular_functionhydrolase activity
B0044174cellular_componenthost cell endosome
B0055036cellular_componentvirion membrane
B0072494cellular_componenthost multivesicular body
Functional Information from PDB Data
site_idAC1
Number of Residues24
Detailsbinding site for residue 7O7 A 400
ChainResidue
AASP25
APRO81
AILE82
AHOH508
AHOH538
BASP25
BGLY27
BALA28
BASP29
BASP30
BILE32
AGLY27
BGLY48
BGLY49
BILE50
BPRO81
BILE82
AALA28
AASP29
AASP30
AILE32
AGLY48
AGLY49
AILE50

Functional Information from PROSITE/UniProt
site_idPS00141
Number of Residues12
DetailsASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALIDTGADDTIF
ChainResidueDetails
AALA22-PHE33

239492

PDB entries from 2025-07-30

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