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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6MJ2

Human TRPM2 ion channel in a calcium- and ADPR-bound state

Functional Information from GO Data
ChainGOidnamespacecontents
A0001659biological_processtemperature homeostasis
A0002407biological_processdendritic cell chemotaxis
A0005216molecular_functionmonoatomic ion channel activity
A0005261molecular_functionmonoatomic cation channel activity
A0005262molecular_functioncalcium channel activity
A0005272molecular_functionsodium channel activity
A0005384molecular_functionmanganese ion transmembrane transporter activity
A0005509molecular_functioncalcium ion binding
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006814biological_processsodium ion transport
A0006816biological_processcalcium ion transport
A0006828biological_processmanganese ion transport
A0009408biological_processresponse to heat
A0014074biological_processresponse to purine-containing compound
A0015278molecular_functionintracellularly gated calcium channel activity
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0019722biological_processcalcium-mediated signaling
A0030659cellular_componentcytoplasmic vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0032956biological_processregulation of actin cytoskeleton organization
A0033194biological_processresponse to hydroperoxide
A0034220biological_processmonoatomic ion transmembrane transport
A0035579cellular_componentspecific granule membrane
A0035725biological_processsodium ion transmembrane transport
A0042995cellular_componentcell projection
A0043204cellular_componentperikaryon
A0046872molecular_functionmetal ion binding
A0046873molecular_functionmetal ion transmembrane transporter activity
A0047631molecular_functionADP-ribose diphosphatase activity
A0051209biological_processrelease of sequestered calcium ion into cytosol
A0051289biological_processprotein homotetramerization
A0051489biological_processregulation of filopodium assembly
A0055085biological_processtransmembrane transport
A0070301biological_processcellular response to hydrogen peroxide
A0070588biological_processcalcium ion transmembrane transport
A0070821cellular_componenttertiary granule membrane
A0071277biological_processcellular response to calcium ion
A0071421biological_processmanganese ion transmembrane transport
A0071502biological_processcellular response to temperature stimulus
A0071577biological_processzinc ion transmembrane transport
A0072571molecular_functionmono-ADP-D-ribose binding
A0097028biological_processdendritic cell differentiation
A0097553biological_processcalcium ion transmembrane import into cytosol
A0098703biological_processcalcium ion import across plasma membrane
A0099604molecular_functionligand-gated calcium channel activity
A0101003cellular_componentficolin-1-rich granule membrane
B0001659biological_processtemperature homeostasis
B0002407biological_processdendritic cell chemotaxis
B0005216molecular_functionmonoatomic ion channel activity
B0005261molecular_functionmonoatomic cation channel activity
B0005262molecular_functioncalcium channel activity
B0005272molecular_functionsodium channel activity
B0005384molecular_functionmanganese ion transmembrane transporter activity
B0005509molecular_functioncalcium ion binding
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006814biological_processsodium ion transport
B0006816biological_processcalcium ion transport
B0006828biological_processmanganese ion transport
B0009408biological_processresponse to heat
B0014074biological_processresponse to purine-containing compound
B0015278molecular_functionintracellularly gated calcium channel activity
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0019722biological_processcalcium-mediated signaling
B0030659cellular_componentcytoplasmic vesicle membrane
B0031410cellular_componentcytoplasmic vesicle
B0032956biological_processregulation of actin cytoskeleton organization
B0033194biological_processresponse to hydroperoxide
B0034220biological_processmonoatomic ion transmembrane transport
B0035579cellular_componentspecific granule membrane
B0035725biological_processsodium ion transmembrane transport
B0042995cellular_componentcell projection
B0043204cellular_componentperikaryon
B0046872molecular_functionmetal ion binding
B0046873molecular_functionmetal ion transmembrane transporter activity
B0047631molecular_functionADP-ribose diphosphatase activity
B0051209biological_processrelease of sequestered calcium ion into cytosol
B0051289biological_processprotein homotetramerization
B0051489biological_processregulation of filopodium assembly
B0055085biological_processtransmembrane transport
B0070301biological_processcellular response to hydrogen peroxide
B0070588biological_processcalcium ion transmembrane transport
B0070821cellular_componenttertiary granule membrane
B0071277biological_processcellular response to calcium ion
B0071421biological_processmanganese ion transmembrane transport
B0071502biological_processcellular response to temperature stimulus
B0071577biological_processzinc ion transmembrane transport
B0072571molecular_functionmono-ADP-D-ribose binding
B0097028biological_processdendritic cell differentiation
B0097553biological_processcalcium ion transmembrane import into cytosol
B0098703biological_processcalcium ion import across plasma membrane
B0099604molecular_functionligand-gated calcium channel activity
B0101003cellular_componentficolin-1-rich granule membrane
C0001659biological_processtemperature homeostasis
C0002407biological_processdendritic cell chemotaxis
C0005216molecular_functionmonoatomic ion channel activity
C0005261molecular_functionmonoatomic cation channel activity
C0005262molecular_functioncalcium channel activity
C0005272molecular_functionsodium channel activity
C0005384molecular_functionmanganese ion transmembrane transporter activity
C0005509molecular_functioncalcium ion binding
C0005764cellular_componentlysosome
C0005765cellular_componentlysosomal membrane
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006814biological_processsodium ion transport
C0006816biological_processcalcium ion transport
C0006828biological_processmanganese ion transport
C0009408biological_processresponse to heat
C0014074biological_processresponse to purine-containing compound
C0015278molecular_functionintracellularly gated calcium channel activity
C0016020cellular_componentmembrane
C0016787molecular_functionhydrolase activity
C0019722biological_processcalcium-mediated signaling
C0030659cellular_componentcytoplasmic vesicle membrane
C0031410cellular_componentcytoplasmic vesicle
C0032956biological_processregulation of actin cytoskeleton organization
C0033194biological_processresponse to hydroperoxide
C0034220biological_processmonoatomic ion transmembrane transport
C0035579cellular_componentspecific granule membrane
C0035725biological_processsodium ion transmembrane transport
C0042995cellular_componentcell projection
C0043204cellular_componentperikaryon
C0046872molecular_functionmetal ion binding
C0046873molecular_functionmetal ion transmembrane transporter activity
C0047631molecular_functionADP-ribose diphosphatase activity
C0051209biological_processrelease of sequestered calcium ion into cytosol
C0051289biological_processprotein homotetramerization
C0051489biological_processregulation of filopodium assembly
C0055085biological_processtransmembrane transport
C0070301biological_processcellular response to hydrogen peroxide
C0070588biological_processcalcium ion transmembrane transport
C0070821cellular_componenttertiary granule membrane
C0071277biological_processcellular response to calcium ion
C0071421biological_processmanganese ion transmembrane transport
C0071502biological_processcellular response to temperature stimulus
C0071577biological_processzinc ion transmembrane transport
C0072571molecular_functionmono-ADP-D-ribose binding
C0097028biological_processdendritic cell differentiation
C0097553biological_processcalcium ion transmembrane import into cytosol
C0098703biological_processcalcium ion import across plasma membrane
C0099604molecular_functionligand-gated calcium channel activity
C0101003cellular_componentficolin-1-rich granule membrane
D0001659biological_processtemperature homeostasis
D0002407biological_processdendritic cell chemotaxis
D0005216molecular_functionmonoatomic ion channel activity
D0005261molecular_functionmonoatomic cation channel activity
D0005262molecular_functioncalcium channel activity
D0005272molecular_functionsodium channel activity
D0005384molecular_functionmanganese ion transmembrane transporter activity
D0005509molecular_functioncalcium ion binding
D0005764cellular_componentlysosome
D0005765cellular_componentlysosomal membrane
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006814biological_processsodium ion transport
D0006816biological_processcalcium ion transport
D0006828biological_processmanganese ion transport
D0009408biological_processresponse to heat
D0014074biological_processresponse to purine-containing compound
D0015278molecular_functionintracellularly gated calcium channel activity
D0016020cellular_componentmembrane
D0016787molecular_functionhydrolase activity
D0019722biological_processcalcium-mediated signaling
D0030659cellular_componentcytoplasmic vesicle membrane
D0031410cellular_componentcytoplasmic vesicle
D0032956biological_processregulation of actin cytoskeleton organization
D0033194biological_processresponse to hydroperoxide
D0034220biological_processmonoatomic ion transmembrane transport
D0035579cellular_componentspecific granule membrane
D0035725biological_processsodium ion transmembrane transport
D0042995cellular_componentcell projection
D0043204cellular_componentperikaryon
D0046872molecular_functionmetal ion binding
D0046873molecular_functionmetal ion transmembrane transporter activity
D0047631molecular_functionADP-ribose diphosphatase activity
D0051209biological_processrelease of sequestered calcium ion into cytosol
D0051289biological_processprotein homotetramerization
D0051489biological_processregulation of filopodium assembly
D0055085biological_processtransmembrane transport
D0070301biological_processcellular response to hydrogen peroxide
D0070588biological_processcalcium ion transmembrane transport
D0070821cellular_componenttertiary granule membrane
D0071277biological_processcellular response to calcium ion
D0071421biological_processmanganese ion transmembrane transport
D0071502biological_processcellular response to temperature stimulus
D0071577biological_processzinc ion transmembrane transport
D0072571molecular_functionmono-ADP-D-ribose binding
D0097028biological_processdendritic cell differentiation
D0097553biological_processcalcium ion transmembrane import into cytosol
D0098703biological_processcalcium ion import across plasma membrane
D0099604molecular_functionligand-gated calcium channel activity
D0101003cellular_componentficolin-1-rich granule membrane
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue CA A 1601
ChainResidue
AGLU843
AGLN846
AASN869
AGLU1073
site_idAC2
Number of Residues4
Detailsbinding site for residue CA B 1601
ChainResidue
BGLU843
BGLN846
BASN869
BGLU1073
site_idAC3
Number of Residues4
Detailsbinding site for residue CA C 1601
ChainResidue
CGLN846
CASN869
CGLU1073
CGLU843
site_idAC4
Number of Residues4
Detailsbinding site for residue CA D 1601
ChainResidue
DGLU843
DGLN846
DASN869
DGLU1073
Functional Information from PROSITE/UniProt
site_idPS01095
Number of Residues9
DetailsGH18_1 Glycosyl hydrolases family 18 (GH18) active site signature. IDGVNFNpE
ChainResidueDetails
AILE986-GLU994
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues136
DetailsIntramembrane: {"evidences":[{"source":"PubMed","id":"30467180","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues352
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues484
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"30467180","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues144
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues56
DetailsIntramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"30467180","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues576
DetailsDomain: {"description":"Nudix hydrolase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues12
DetailsMotif: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"34788616","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues84
DetailsMotif: {"description":"Nudix box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues20
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31513012","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PUR","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31513012","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30467180","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6PUS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PUU","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31513012","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30467180","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6PUS","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"30467180","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues24
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31513012","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PUS","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q91YD4","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

244349

PDB entries from 2025-11-05

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