6MHY

Structure of connexin-50 intercellular gap junction channel at 3.4 angstrom resolution by cryoEM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005243	molecular_function	gap junction channel activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0005921	cellular_component	gap junction
A	0005922	cellular_component	connexin complex
A	0007154	biological_process	cell communication
A	0007267	biological_process	cell-cell signaling
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
A	0070161	cellular_component	anchoring junction
A	0098797	cellular_component	plasma membrane protein complex
A	1990349	biological_process	gap junction-mediated intercellular transport
B	0005243	molecular_function	gap junction channel activity
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0005921	cellular_component	gap junction
B	0005922	cellular_component	connexin complex
B	0007154	biological_process	cell communication
B	0007267	biological_process	cell-cell signaling
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
B	0070161	cellular_component	anchoring junction
B	0098797	cellular_component	plasma membrane protein complex
B	1990349	biological_process	gap junction-mediated intercellular transport
C	0005243	molecular_function	gap junction channel activity
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0005921	cellular_component	gap junction
C	0005922	cellular_component	connexin complex
C	0007154	biological_process	cell communication
C	0007267	biological_process	cell-cell signaling
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
C	0070161	cellular_component	anchoring junction
C	0098797	cellular_component	plasma membrane protein complex
C	1990349	biological_process	gap junction-mediated intercellular transport
D	0005243	molecular_function	gap junction channel activity
D	0005515	molecular_function	protein binding
D	0005886	cellular_component	plasma membrane
D	0005921	cellular_component	gap junction
D	0005922	cellular_component	connexin complex
D	0007154	biological_process	cell communication
D	0007267	biological_process	cell-cell signaling
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport
D	0070161	cellular_component	anchoring junction
D	0098797	cellular_component	plasma membrane protein complex
D	1990349	biological_process	gap junction-mediated intercellular transport
E	0005243	molecular_function	gap junction channel activity
E	0005515	molecular_function	protein binding
E	0005886	cellular_component	plasma membrane
E	0005921	cellular_component	gap junction
E	0005922	cellular_component	connexin complex
E	0007154	biological_process	cell communication
E	0007267	biological_process	cell-cell signaling
E	0016020	cellular_component	membrane
E	0055085	biological_process	transmembrane transport
E	0070161	cellular_component	anchoring junction
E	0098797	cellular_component	plasma membrane protein complex
E	1990349	biological_process	gap junction-mediated intercellular transport
F	0005243	molecular_function	gap junction channel activity
F	0005515	molecular_function	protein binding
F	0005886	cellular_component	plasma membrane
F	0005921	cellular_component	gap junction
F	0005922	cellular_component	connexin complex
F	0007154	biological_process	cell communication
F	0007267	biological_process	cell-cell signaling
F	0016020	cellular_component	membrane
F	0055085	biological_process	transmembrane transport
F	0070161	cellular_component	anchoring junction
F	0098797	cellular_component	plasma membrane protein complex
F	1990349	biological_process	gap junction-mediated intercellular transport
G	0005243	molecular_function	gap junction channel activity
G	0005515	molecular_function	protein binding
G	0005886	cellular_component	plasma membrane
G	0005921	cellular_component	gap junction
G	0005922	cellular_component	connexin complex
G	0007154	biological_process	cell communication
G	0007267	biological_process	cell-cell signaling
G	0016020	cellular_component	membrane
G	0055085	biological_process	transmembrane transport
G	0070161	cellular_component	anchoring junction
G	0098797	cellular_component	plasma membrane protein complex
G	1990349	biological_process	gap junction-mediated intercellular transport
H	0005243	molecular_function	gap junction channel activity
H	0005515	molecular_function	protein binding
H	0005886	cellular_component	plasma membrane
H	0005921	cellular_component	gap junction
H	0005922	cellular_component	connexin complex
H	0007154	biological_process	cell communication
H	0007267	biological_process	cell-cell signaling
H	0016020	cellular_component	membrane
H	0055085	biological_process	transmembrane transport
H	0070161	cellular_component	anchoring junction
H	0098797	cellular_component	plasma membrane protein complex
H	1990349	biological_process	gap junction-mediated intercellular transport
I	0005243	molecular_function	gap junction channel activity
I	0005515	molecular_function	protein binding
I	0005886	cellular_component	plasma membrane
I	0005921	cellular_component	gap junction
I	0005922	cellular_component	connexin complex
I	0007154	biological_process	cell communication
I	0007267	biological_process	cell-cell signaling
I	0016020	cellular_component	membrane
I	0055085	biological_process	transmembrane transport
I	0070161	cellular_component	anchoring junction
I	0098797	cellular_component	plasma membrane protein complex
I	1990349	biological_process	gap junction-mediated intercellular transport
J	0005243	molecular_function	gap junction channel activity
J	0005515	molecular_function	protein binding
J	0005886	cellular_component	plasma membrane
J	0005921	cellular_component	gap junction
J	0005922	cellular_component	connexin complex
J	0007154	biological_process	cell communication
J	0007267	biological_process	cell-cell signaling
J	0016020	cellular_component	membrane
J	0055085	biological_process	transmembrane transport
J	0070161	cellular_component	anchoring junction
J	0098797	cellular_component	plasma membrane protein complex
J	1990349	biological_process	gap junction-mediated intercellular transport
K	0005243	molecular_function	gap junction channel activity
K	0005515	molecular_function	protein binding
K	0005886	cellular_component	plasma membrane
K	0005921	cellular_component	gap junction
K	0005922	cellular_component	connexin complex
K	0007154	biological_process	cell communication
K	0007267	biological_process	cell-cell signaling
K	0016020	cellular_component	membrane
K	0055085	biological_process	transmembrane transport
K	0070161	cellular_component	anchoring junction
K	0098797	cellular_component	plasma membrane protein complex
K	1990349	biological_process	gap junction-mediated intercellular transport
L	0005243	molecular_function	gap junction channel activity
L	0005515	molecular_function	protein binding
L	0005886	cellular_component	plasma membrane
L	0005921	cellular_component	gap junction
L	0005922	cellular_component	connexin complex
L	0007154	biological_process	cell communication
L	0007267	biological_process	cell-cell signaling
L	0016020	cellular_component	membrane
L	0055085	biological_process	transmembrane transport
L	0070161	cellular_component	anchoring junction
L	0098797	cellular_component	plasma membrane protein complex
L	1990349	biological_process	gap junction-mediated intercellular transport

Functional Information from PROSITE/UniProt

site_id	PS00407
Number of Residues	14
Details	CONNEXINS_1 Connexins signature 1. CNTqQPGCenVCYD

Chain	Residue	Details
A	CYS54-ASP67

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site_id	PS00408
Number of Residues	17
Details	CONNEXINS_2 Connexins signature 2. Csrw.PCpnvVDCFVSRP

Chain	Residue	Details
A	CYS190-PRO206

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	120
Details	Intramembrane: {"evidences":[{"source":"PubMed","id":"30542154","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	96
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"30542154","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	960
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"30542154","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	660
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"30542154","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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