Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6MHY

Structure of connexin-50 intercellular gap junction channel at 3.4 angstrom resolution by cryoEM

Functional Information from GO Data
ChainGOidnamespacecontents
A0005243molecular_functiongap junction channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0005921cellular_componentgap junction
A0005922cellular_componentconnexin complex
A0007154biological_processcell communication
A0007267biological_processcell-cell signaling
A0055085biological_processtransmembrane transport
A1990349biological_processgap junction-mediated intercellular transport
B0005243molecular_functiongap junction channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0005921cellular_componentgap junction
B0005922cellular_componentconnexin complex
B0007154biological_processcell communication
B0007267biological_processcell-cell signaling
B0055085biological_processtransmembrane transport
B1990349biological_processgap junction-mediated intercellular transport
C0005243molecular_functiongap junction channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0005921cellular_componentgap junction
C0005922cellular_componentconnexin complex
C0007154biological_processcell communication
C0007267biological_processcell-cell signaling
C0055085biological_processtransmembrane transport
C1990349biological_processgap junction-mediated intercellular transport
D0005243molecular_functiongap junction channel activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0005921cellular_componentgap junction
D0005922cellular_componentconnexin complex
D0007154biological_processcell communication
D0007267biological_processcell-cell signaling
D0055085biological_processtransmembrane transport
D1990349biological_processgap junction-mediated intercellular transport
E0005243molecular_functiongap junction channel activity
E0005515molecular_functionprotein binding
E0005886cellular_componentplasma membrane
E0005921cellular_componentgap junction
E0005922cellular_componentconnexin complex
E0007154biological_processcell communication
E0007267biological_processcell-cell signaling
E0055085biological_processtransmembrane transport
E1990349biological_processgap junction-mediated intercellular transport
F0005243molecular_functiongap junction channel activity
F0005515molecular_functionprotein binding
F0005886cellular_componentplasma membrane
F0005921cellular_componentgap junction
F0005922cellular_componentconnexin complex
F0007154biological_processcell communication
F0007267biological_processcell-cell signaling
F0055085biological_processtransmembrane transport
F1990349biological_processgap junction-mediated intercellular transport
G0005243molecular_functiongap junction channel activity
G0005515molecular_functionprotein binding
G0005886cellular_componentplasma membrane
G0005921cellular_componentgap junction
G0005922cellular_componentconnexin complex
G0007154biological_processcell communication
G0007267biological_processcell-cell signaling
G0055085biological_processtransmembrane transport
G1990349biological_processgap junction-mediated intercellular transport
H0005243molecular_functiongap junction channel activity
H0005515molecular_functionprotein binding
H0005886cellular_componentplasma membrane
H0005921cellular_componentgap junction
H0005922cellular_componentconnexin complex
H0007154biological_processcell communication
H0007267biological_processcell-cell signaling
H0055085biological_processtransmembrane transport
H1990349biological_processgap junction-mediated intercellular transport
I0005243molecular_functiongap junction channel activity
I0005515molecular_functionprotein binding
I0005886cellular_componentplasma membrane
I0005921cellular_componentgap junction
I0005922cellular_componentconnexin complex
I0007154biological_processcell communication
I0007267biological_processcell-cell signaling
I0055085biological_processtransmembrane transport
I1990349biological_processgap junction-mediated intercellular transport
J0005243molecular_functiongap junction channel activity
J0005515molecular_functionprotein binding
J0005886cellular_componentplasma membrane
J0005921cellular_componentgap junction
J0005922cellular_componentconnexin complex
J0007154biological_processcell communication
J0007267biological_processcell-cell signaling
J0055085biological_processtransmembrane transport
J1990349biological_processgap junction-mediated intercellular transport
K0005243molecular_functiongap junction channel activity
K0005515molecular_functionprotein binding
K0005886cellular_componentplasma membrane
K0005921cellular_componentgap junction
K0005922cellular_componentconnexin complex
K0007154biological_processcell communication
K0007267biological_processcell-cell signaling
K0055085biological_processtransmembrane transport
K1990349biological_processgap junction-mediated intercellular transport
L0005243molecular_functiongap junction channel activity
L0005515molecular_functionprotein binding
L0005886cellular_componentplasma membrane
L0005921cellular_componentgap junction
L0005922cellular_componentconnexin complex
L0007154biological_processcell communication
L0007267biological_processcell-cell signaling
L0055085biological_processtransmembrane transport
L1990349biological_processgap junction-mediated intercellular transport
Functional Information from PROSITE/UniProt
site_idPS00407
Number of Residues14
DetailsCONNEXINS_1 Connexins signature 1. CNTqQPGCenVCYD
ChainResidueDetails
ACYS54-ASP67

site_idPS00408
Number of Residues17
DetailsCONNEXINS_2 Connexins signature 2. Csrw.PCpnvVDCFVSRP
ChainResidueDetails
ACYS190-PRO206

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues120
DetailsINTRAMEM: INTRAMEM => ECO:0000269|PubMed:30542154
ChainResidueDetails
AGLY2-GLU12
JGLY2-GLU12
KGLY2-GLU12
LGLY2-GLU12
BGLY2-GLU12
CGLY2-GLU12
DGLY2-GLU12
EGLY2-GLU12
FGLY2-GLU12
GGLY2-GLU12
HGLY2-GLU12
IGLY2-GLU12

site_idSWS_FT_FI2
Number of Residues3408
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:30542154
ChainResidueDetails
AGLU13-ILE21
DGLU13-ILE21
DVAL93-HIS161
DSER232-VAL440
EGLU13-ILE21
EVAL93-HIS161
ESER232-VAL440
FGLU13-ILE21
FVAL93-HIS161
FSER232-VAL440
GGLU13-ILE21
AVAL93-HIS161
GVAL93-HIS161
GSER232-VAL440
HGLU13-ILE21
HVAL93-HIS161
HSER232-VAL440
IGLU13-ILE21
IVAL93-HIS161
ISER232-VAL440
JGLU13-ILE21
JVAL93-HIS161
ASER232-VAL440
JSER232-VAL440
KGLU13-ILE21
KVAL93-HIS161
KSER232-VAL440
LGLU13-ILE21
LVAL93-HIS161
LSER232-VAL440
BGLU13-ILE21
BVAL93-HIS161
BSER232-VAL440
CGLU13-ILE21
CVAL93-HIS161
CSER232-VAL440

site_idSWS_FT_FI3
Number of Residues960
DetailsTRANSMEM: Helical => ECO:0000269|PubMed:30542154
ChainResidueDetails
AGLY22-ASP42
CILE72-TYR92
CILE162-PHE182
CILE211-MET231
DGLY22-ASP42
DILE72-TYR92
DILE162-PHE182
DILE211-MET231
EGLY22-ASP42
EILE72-TYR92
EILE162-PHE182
AILE72-TYR92
EILE211-MET231
FGLY22-ASP42
FILE72-TYR92
FILE162-PHE182
FILE211-MET231
GGLY22-ASP42
GILE72-TYR92
GILE162-PHE182
GILE211-MET231
HGLY22-ASP42
AILE162-PHE182
HILE72-TYR92
HILE162-PHE182
HILE211-MET231
IGLY22-ASP42
IILE72-TYR92
IILE162-PHE182
IILE211-MET231
JGLY22-ASP42
JILE72-TYR92
JILE162-PHE182
AILE211-MET231
JILE211-MET231
KGLY22-ASP42
KILE72-TYR92
KILE162-PHE182
KILE211-MET231
LGLY22-ASP42
LILE72-TYR92
LILE162-PHE182
LILE211-MET231
BGLY22-ASP42
BILE72-TYR92
BILE162-PHE182
BILE211-MET231
CGLY22-ASP42

site_idSWS_FT_FI4
Number of Residues660
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:30542154
ChainResidueDetails
APHE43-PRO71
EARG183-THR210
FPHE43-PRO71
FARG183-THR210
GPHE43-PRO71
GARG183-THR210
HPHE43-PRO71
HARG183-THR210
IPHE43-PRO71
IARG183-THR210
JPHE43-PRO71
AARG183-THR210
JARG183-THR210
KPHE43-PRO71
KARG183-THR210
LPHE43-PRO71
LARG183-THR210
BPHE43-PRO71
BARG183-THR210
CPHE43-PRO71
CARG183-THR210
DPHE43-PRO71
DARG183-THR210
EPHE43-PRO71

222036

PDB entries from 2024-07-03

PDB statisticsPDBj update infoContact PDBjnumon