6MHC
Glutathione S-Transferase Omega 1 bound to covalent inhibitor 37
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004364 | molecular_function | glutathione transferase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006749 | biological_process | glutathione metabolic process |
| A | 0010880 | biological_process | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| A | 0010881 | biological_process | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| A | 0014810 | biological_process | positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019852 | biological_process | L-ascorbic acid metabolic process |
| A | 0042178 | biological_process | xenobiotic catabolic process |
| A | 0045174 | molecular_function | glutathione dehydrogenase (ascorbate) activity |
| A | 0050610 | molecular_function | methylarsonate reductase activity |
| A | 0051280 | biological_process | negative regulation of release of sequestered calcium ion into cytosol |
| A | 0051281 | biological_process | positive regulation of release of sequestered calcium ion into cytosol |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071243 | biological_process | cellular response to arsenic-containing substance |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0004364 | molecular_function | glutathione transferase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006749 | biological_process | glutathione metabolic process |
| B | 0010880 | biological_process | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| B | 0010881 | biological_process | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| B | 0014810 | biological_process | positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0019852 | biological_process | L-ascorbic acid metabolic process |
| B | 0042178 | biological_process | xenobiotic catabolic process |
| B | 0045174 | molecular_function | glutathione dehydrogenase (ascorbate) activity |
| B | 0050610 | molecular_function | methylarsonate reductase activity |
| B | 0051280 | biological_process | negative regulation of release of sequestered calcium ion into cytosol |
| B | 0051281 | biological_process | positive regulation of release of sequestered calcium ion into cytosol |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0071243 | biological_process | cellular response to arsenic-containing substance |
| B | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue JRM A 301 |
| Chain | Residue |
| A | MET29 |
| A | CYS32 |
| A | LEU56 |
| A | VAL72 |
| A | GLY128 |
| A | ARG132 |
| A | TYR229 |
| A | LEU230 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue DMS A 302 |
| Chain | Residue |
| A | LYS59 |
| A | LEU71 |
| A | TYR229 |
| A | HOH489 |
| A | LEU56 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue PEG A 303 |
| Chain | Residue |
| A | LYS43 |
| A | THR211 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue MES A 304 |
| Chain | Residue |
| A | PHE34 |
| A | GLU85 |
| A | SER86 |
| A | HOH429 |
| A | HOH456 |
| A | HOH481 |
| B | GLU118 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue DMS B 302 |
| Chain | Residue |
| B | LYS59 |
| B | LEU71 |
| B | TYR229 |
| B | JRM301 |
| B | HOH508 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue PEG B 303 |
| Chain | Residue |
| B | LYS43 |
| B | ALA44 |
| B | GLY46 |
| B | THR211 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | binding site for residue MES B 304 |
| Chain | Residue |
| A | GLU118 |
| A | HOH453 |
| B | PHE34 |
| B | GLU85 |
| B | SER86 |
| B | HOH449 |
| B | HOH473 |
| B | HOH479 |
| B | HOH483 |
| site_id | AC8 |
| Number of Residues | 16 |
| Details | binding site for Di-peptide JRM B 301 and CYS B 32 |
| Chain | Residue |
| B | MET29 |
| B | ARG30 |
| B | PHE31 |
| B | PRO33 |
| B | PHE34 |
| B | ALA35 |
| B | GLU36 |
| B | LEU56 |
| B | VAL72 |
| B | GLY128 |
| B | ILE131 |
| B | ARG132 |
| B | TYR229 |
| B | LEU230 |
| B | DMS302 |
| B | HOH419 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 158 |
| Details | Domain: {"description":"GST N-terminal"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 248 |
| Details | Domain: {"description":"GST C-terminal"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"10783391","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10783391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21106529","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
