Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6MHB

Glutathione S-Transferase Omega 1 bound to covalent inhibitor 18

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004364	molecular_function	glutathione transferase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006749	biological_process	glutathione metabolic process
A	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A	0014810	biological_process	positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
A	0016491	molecular_function	oxidoreductase activity
A	0016740	molecular_function	transferase activity
A	0019852	biological_process	L-ascorbic acid metabolic process
A	0042178	biological_process	xenobiotic catabolic process
A	0045174	molecular_function	glutathione dehydrogenase (ascorbate) activity
A	0050610	molecular_function	methylarsonate reductase activity
A	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
A	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
A	0070062	cellular_component	extracellular exosome
A	0071243	biological_process	cellular response to arsenic-containing substance
A	0098869	biological_process	cellular oxidant detoxification
B	0004364	molecular_function	glutathione transferase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006749	biological_process	glutathione metabolic process
B	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
B	0014810	biological_process	positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
B	0016491	molecular_function	oxidoreductase activity
B	0016740	molecular_function	transferase activity
B	0019852	biological_process	L-ascorbic acid metabolic process
B	0042178	biological_process	xenobiotic catabolic process
B	0045174	molecular_function	glutathione dehydrogenase (ascorbate) activity
B	0050610	molecular_function	methylarsonate reductase activity
B	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
B	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
B	0070062	cellular_component	extracellular exosome
B	0071243	biological_process	cellular response to arsenic-containing substance
B	0098869	biological_process	cellular oxidant detoxification
C	0004364	molecular_function	glutathione transferase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006749	biological_process	glutathione metabolic process
C	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
C	0014810	biological_process	positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
C	0016491	molecular_function	oxidoreductase activity
C	0016740	molecular_function	transferase activity
C	0019852	biological_process	L-ascorbic acid metabolic process
C	0042178	biological_process	xenobiotic catabolic process
C	0045174	molecular_function	glutathione dehydrogenase (ascorbate) activity
C	0050610	molecular_function	methylarsonate reductase activity
C	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
C	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
C	0070062	cellular_component	extracellular exosome
C	0071243	biological_process	cellular response to arsenic-containing substance
C	0098869	biological_process	cellular oxidant detoxification
D	0004364	molecular_function	glutathione transferase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006749	biological_process	glutathione metabolic process
D	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
D	0014810	biological_process	positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
D	0016491	molecular_function	oxidoreductase activity
D	0016740	molecular_function	transferase activity
D	0019852	biological_process	L-ascorbic acid metabolic process
D	0042178	biological_process	xenobiotic catabolic process
D	0045174	molecular_function	glutathione dehydrogenase (ascorbate) activity
D	0050610	molecular_function	methylarsonate reductase activity
D	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
D	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
D	0070062	cellular_component	extracellular exosome
D	0071243	biological_process	cellular response to arsenic-containing substance
D	0098869	biological_process	cellular oxidant detoxification
E	0004364	molecular_function	glutathione transferase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006749	biological_process	glutathione metabolic process
E	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
E	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
E	0014810	biological_process	positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
E	0016491	molecular_function	oxidoreductase activity
E	0016740	molecular_function	transferase activity
E	0019852	biological_process	L-ascorbic acid metabolic process
E	0042178	biological_process	xenobiotic catabolic process
E	0045174	molecular_function	glutathione dehydrogenase (ascorbate) activity
E	0050610	molecular_function	methylarsonate reductase activity
E	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
E	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
E	0070062	cellular_component	extracellular exosome
E	0071243	biological_process	cellular response to arsenic-containing substance
E	0098869	biological_process	cellular oxidant detoxification
F	0004364	molecular_function	glutathione transferase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006749	biological_process	glutathione metabolic process
F	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
F	0014810	biological_process	positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
F	0016491	molecular_function	oxidoreductase activity
F	0016740	molecular_function	transferase activity
F	0019852	biological_process	L-ascorbic acid metabolic process
F	0042178	biological_process	xenobiotic catabolic process
F	0045174	molecular_function	glutathione dehydrogenase (ascorbate) activity
F	0050610	molecular_function	methylarsonate reductase activity
F	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
F	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
F	0070062	cellular_component	extracellular exosome
F	0071243	biological_process	cellular response to arsenic-containing substance
F	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue JR7 A 601

Chain	Residue
A	PHE31
A	CYS32
A	PRO33
A	PHE34
A	ARG183
A	TRP222
A	PHE225
A	LEU226

site_id	AC2
Number of Residues	7
Details	binding site for residue MES A 602

Chain	Residue
A	PHE69
A	PRO73
A	GLU85
A	SER86
A	HOH708
C	GLU118
A	PHE34

site_id	AC3
Number of Residues	8
Details	binding site for residue MES C 602

Chain	Residue
A	GLU118
C	PHE34
C	LEU71
C	VAL72
C	GLU85
C	SER86
C	HOH707
C	HOH709

site_id	AC4
Number of Residues	7
Details	binding site for residue MES D 602

Chain	Residue
D	PHE34
D	LEU71
D	GLU85
D	SER86
D	HOH705
D	HOH711
E	GLU118

site_id	AC5
Number of Residues	7
Details	binding site for residue MES F 602

Chain	Residue
B	GLU118
F	PHE34
F	VAL72
F	PRO73
F	GLU85
F	SER86
F	HOH701

site_id	AC6
Number of Residues	12
Details	binding site for Di-peptide JR7 B 601 and CYS B 32

Chain	Residue
B	MET29
B	ARG30
B	PHE31
B	PRO33
B	PHE34
B	ALA35
B	GLU36
B	ARG183
B	TRP222
B	PHE225
B	LEU226
B	HOH702

site_id	AC7
Number of Residues	12
Details	binding site for Di-peptide JR7 C 601 and CYS C 32

Chain	Residue
C	MET29
C	ARG30
C	PHE31
C	PRO33
C	PHE34
C	ALA35
C	GLU36
C	ARG183
C	TRP222
C	PHE225
C	LEU226
C	TYR229

site_id	AC8
Number of Residues	11
Details	binding site for Di-peptide JR7 D 601 and CYS D 32

Chain	Residue
D	MET29
D	ARG30
D	PHE31
D	PRO33
D	PHE34
D	ALA35
D	GLU36
D	ARG183
D	TRP222
D	PHE225
D	LEU226

site_id	AC9
Number of Residues	11
Details	binding site for Di-peptide JR7 E 601 and CYS E 32

Chain	Residue
E	MET29
E	ARG30
E	PHE31
E	PRO33
E	PHE34
E	ALA35
E	GLU36
E	ARG183
E	TRP222
E	PHE225
E	LEU226

site_id	AD1
Number of Residues	11
Details	binding site for Di-peptide JR7 F 601 and CYS F 32

Chain	Residue
F	MET29
F	ARG30
F	PHE31
F	PRO33
F	PHE34
F	ALA35
F	GLU36
F	LEU56
F	ARG183
F	TRP222
F	PHE225

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	395
Details	Domain: {"description":"GST N-terminal"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	6
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"10783391","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10783391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21106529","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	23
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)