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6MHB

Glutathione S-Transferase Omega 1 bound to covalent inhibitor 18

Functional Information from GO Data
ChainGOidnamespacecontents
A0004364molecular_functionglutathione transferase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006749biological_processglutathione metabolic process
A0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A0014810biological_processpositive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
A0016491molecular_functionoxidoreductase activity
A0016740molecular_functiontransferase activity
A0019852biological_processL-ascorbic acid metabolic process
A0042178biological_processxenobiotic catabolic process
A0045174molecular_functionglutathione dehydrogenase (ascorbate) activity
A0050610molecular_functionmethylarsonate reductase activity
A0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
A0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
A0070062cellular_componentextracellular exosome
A0071243biological_processcellular response to arsenic-containing substance
A0098869biological_processcellular oxidant detoxification
B0004364molecular_functionglutathione transferase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006749biological_processglutathione metabolic process
B0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
B0014810biological_processpositive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
B0016491molecular_functionoxidoreductase activity
B0016740molecular_functiontransferase activity
B0019852biological_processL-ascorbic acid metabolic process
B0042178biological_processxenobiotic catabolic process
B0045174molecular_functionglutathione dehydrogenase (ascorbate) activity
B0050610molecular_functionmethylarsonate reductase activity
B0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
B0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
B0070062cellular_componentextracellular exosome
B0071243biological_processcellular response to arsenic-containing substance
B0098869biological_processcellular oxidant detoxification
C0004364molecular_functionglutathione transferase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006749biological_processglutathione metabolic process
C0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
C0014810biological_processpositive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
C0016491molecular_functionoxidoreductase activity
C0016740molecular_functiontransferase activity
C0019852biological_processL-ascorbic acid metabolic process
C0042178biological_processxenobiotic catabolic process
C0045174molecular_functionglutathione dehydrogenase (ascorbate) activity
C0050610molecular_functionmethylarsonate reductase activity
C0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
C0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
C0070062cellular_componentextracellular exosome
C0071243biological_processcellular response to arsenic-containing substance
C0098869biological_processcellular oxidant detoxification
D0004364molecular_functionglutathione transferase activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006749biological_processglutathione metabolic process
D0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
D0014810biological_processpositive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
D0016491molecular_functionoxidoreductase activity
D0016740molecular_functiontransferase activity
D0019852biological_processL-ascorbic acid metabolic process
D0042178biological_processxenobiotic catabolic process
D0045174molecular_functionglutathione dehydrogenase (ascorbate) activity
D0050610molecular_functionmethylarsonate reductase activity
D0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
D0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
D0070062cellular_componentextracellular exosome
D0071243biological_processcellular response to arsenic-containing substance
D0098869biological_processcellular oxidant detoxification
E0004364molecular_functionglutathione transferase activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0006749biological_processglutathione metabolic process
E0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
E0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
E0014810biological_processpositive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
E0016491molecular_functionoxidoreductase activity
E0016740molecular_functiontransferase activity
E0019852biological_processL-ascorbic acid metabolic process
E0042178biological_processxenobiotic catabolic process
E0045174molecular_functionglutathione dehydrogenase (ascorbate) activity
E0050610molecular_functionmethylarsonate reductase activity
E0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
E0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
E0070062cellular_componentextracellular exosome
E0071243biological_processcellular response to arsenic-containing substance
E0098869biological_processcellular oxidant detoxification
F0004364molecular_functionglutathione transferase activity
F0005515molecular_functionprotein binding
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0006749biological_processglutathione metabolic process
F0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
F0014810biological_processpositive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
F0016491molecular_functionoxidoreductase activity
F0016740molecular_functiontransferase activity
F0019852biological_processL-ascorbic acid metabolic process
F0042178biological_processxenobiotic catabolic process
F0045174molecular_functionglutathione dehydrogenase (ascorbate) activity
F0050610molecular_functionmethylarsonate reductase activity
F0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
F0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
F0070062cellular_componentextracellular exosome
F0071243biological_processcellular response to arsenic-containing substance
F0098869biological_processcellular oxidant detoxification
Functional Information from PDB Data
site_idAC1
Number of Residues8
Detailsbinding site for residue JR7 A 601
ChainResidue
APHE31
ACYS32
APRO33
APHE34
AARG183
ATRP222
APHE225
ALEU226

site_idAC2
Number of Residues7
Detailsbinding site for residue MES A 602
ChainResidue
APHE69
APRO73
AGLU85
ASER86
AHOH708
CGLU118
APHE34

site_idAC3
Number of Residues8
Detailsbinding site for residue MES C 602
ChainResidue
AGLU118
CPHE34
CLEU71
CVAL72
CGLU85
CSER86
CHOH707
CHOH709

site_idAC4
Number of Residues7
Detailsbinding site for residue MES D 602
ChainResidue
DPHE34
DLEU71
DGLU85
DSER86
DHOH705
DHOH711
EGLU118

site_idAC5
Number of Residues7
Detailsbinding site for residue MES F 602
ChainResidue
BGLU118
FPHE34
FVAL72
FPRO73
FGLU85
FSER86
FHOH701

site_idAC6
Number of Residues12
Detailsbinding site for Di-peptide JR7 B 601 and CYS B 32
ChainResidue
BMET29
BARG30
BPHE31
BPRO33
BPHE34
BALA35
BGLU36
BARG183
BTRP222
BPHE225
BLEU226
BHOH702

site_idAC7
Number of Residues12
Detailsbinding site for Di-peptide JR7 C 601 and CYS C 32
ChainResidue
CMET29
CARG30
CPHE31
CPRO33
CPHE34
CALA35
CGLU36
CARG183
CTRP222
CPHE225
CLEU226
CTYR229

site_idAC8
Number of Residues11
Detailsbinding site for Di-peptide JR7 D 601 and CYS D 32
ChainResidue
DMET29
DARG30
DPHE31
DPRO33
DPHE34
DALA35
DGLU36
DARG183
DTRP222
DPHE225
DLEU226

site_idAC9
Number of Residues11
Detailsbinding site for Di-peptide JR7 E 601 and CYS E 32
ChainResidue
EMET29
EARG30
EPHE31
EPRO33
EPHE34
EALA35
EGLU36
EARG183
ETRP222
EPHE225
ELEU226

site_idAD1
Number of Residues11
Detailsbinding site for Di-peptide JR7 F 601 and CYS F 32
ChainResidue
FMET29
FARG30
FPHE31
FPRO33
FPHE34
FALA35
FGLU36
FLEU56
FARG183
FTRP222
FPHE225

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsACT_SITE: Nucleophile => ECO:0000269|PubMed:10783391
ChainResidueDetails
ACYS32
BCYS32
CCYS32
DCYS32
ECYS32
FCYS32

site_idSWS_FT_FI2
Number of Residues18
DetailsBINDING: BINDING => ECO:0000269|PubMed:10783391, ECO:0000269|PubMed:21106529
ChainResidueDetails
ALYS59
DLYS59
DVAL72
DGLU85
ELYS59
EVAL72
EGLU85
FLYS59
FVAL72
FGLU85
AVAL72
AGLU85
BLYS59
BVAL72
BGLU85
CLYS59
CVAL72
CGLU85

site_idSWS_FT_FI3
Number of Residues6
DetailsMOD_RES: N-acetylserine => ECO:0007744|PubMed:19413330
ChainResidueDetails
ASER2
BSER2
CSER2
DSER2
ESER2
FSER2

site_idSWS_FT_FI4
Number of Residues24
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS57
CLYS143
CLYS148
CLYS152
DLYS57
DLYS143
DLYS148
DLYS152
ELYS57
ELYS143
ELYS148
ALYS143
ELYS152
FLYS57
FLYS143
FLYS148
FLYS152
ALYS148
ALYS152
BLYS57
BLYS143
BLYS148
BLYS152
CLYS57

site_idSWS_FT_FI5
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER129
BSER129
CSER129
DSER129
ESER129
FSER129

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PDB entries from 2024-07-10

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