6MH1

CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH HU-10, A 1,4,5-Trisubstituted Imidazole Analogue

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue JQP A 201

Chain	Residue
A	TRP81
A	HOH368
A	HOH399
B	JQP201
A	PRO82
A	PHE83
A	LEU92
A	TYR97
A	MET132
A	ASN140
A	HOH316
A	HOH332

---

site_id	AC2
Number of Residues	7
Details	binding site for residue EDO A 202

Chain	Residue
A	ILE100
A	ILE101
A	LYS102
A	THR103
A	ASN135
B	ASN116
B	HOH313

---

site_id	AC3
Number of Residues	5
Details	binding site for residue EDO A 203

Chain	Residue
A	ASN130
A	THR134
A	TYR137
A	GLU154
B	HOH306

---

site_id	AC4
Number of Residues	16
Details	binding site for residue JQP B 201

Chain	Residue
A	ASP145
A	MET149
A	JQP201
B	TRP81
B	PRO82
B	PHE83
B	LEU92
B	TYR97
B	MET132
B	CYS136
B	ASN140
B	ILE146
B	HOH317
B	HOH372
B	HOH380
B	HOH393

---

site_id	AC5
Number of Residues	5
Details	binding site for residue EDO B 202

Chain	Residue
B	ILE100
B	ILE101
B	LYS102
B	THR103
B	ASN135

---

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY

Chain	Residue	Details
A	ALA80-TYR139

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	212
Details	Domain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Site: {"description":"Acetylated histone binding","evidences":[{"source":"PubMed","id":"22464331","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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