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6MBO

GLP Methyltransferase with Inhibitor EML741-P212121 Crystal Form

Functional Information from GO Data
ChainGOidnamespacecontents
A0002039molecular_functionp53 binding
A0005634cellular_componentnucleus
A0008270molecular_functionzinc ion binding
A0016279molecular_functionprotein-lysine N-methyltransferase activity
A0042054molecular_functionhistone methyltransferase activity
B0002039molecular_functionp53 binding
B0005634cellular_componentnucleus
B0008270molecular_functionzinc ion binding
B0016279molecular_functionprotein-lysine N-methyltransferase activity
B0042054molecular_functionhistone methyltransferase activity
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue JDG A 1301
ChainResidue
ATHR1026
ATYR1030
BSER1040
BGLN1046
BPHE1160
BTYR1161

site_idAC2
Number of Residues19
Detailsbinding site for residue JDG A 1302
ChainResidue
AARG1137
AASP1140
ASER1141
ALEU1143
AASP1145
AVAL1153
ATYR1154
APHE1209
ATYR1211
AARG1214
APHE1215
AILE1218
ALYS1219
AHOH1417
AHOH1497
AHOH1583
ATYR1124
AALA1134
AASP1135

site_idAC3
Number of Residues4
Detailsbinding site for residue ZN A 1303
ChainResidue
ACYS1037
ACYS1074
ACYS1080
ACYS1084

site_idAC4
Number of Residues4
Detailsbinding site for residue ZN A 1304
ChainResidue
ACYS1031
ACYS1044
ACYS1074
ACYS1078

site_idAC5
Number of Residues4
Detailsbinding site for residue ZN A 1305
ChainResidue
ACYS1031
ACYS1033
ACYS1037
ACYS1042

site_idAC6
Number of Residues4
Detailsbinding site for residue ZN A 1306
ChainResidue
ACYS1172
ACYS1225
ACYS1227
ACYS1232

site_idAC7
Number of Residues15
Detailsbinding site for residue SAH A 1307
ChainResidue
AMET1105
ATRP1107
ASER1141
ATYR1142
AARG1166
APHE1167
AASN1169
AHIS1170
ATYR1211
ACYS1225
AARG1226
AEDO1309
AHOH1413
AHOH1452
AHOH1518

site_idAC8
Number of Residues7
Detailsbinding site for residue EDO A 1308
ChainResidue
AARG1101
ATHR1102
AARG1103
AASP1104
AMET1105
AGLY1106
AHOH1561

site_idAC9
Number of Residues3
Detailsbinding site for residue EDO A 1309
ChainResidue
APHE1223
ASAH1307
AHOH1411

site_idAD1
Number of Residues7
Detailsbinding site for residue EDO A 1310
ChainResidue
ACYS1033
AILE1034
AASP1035
ASER1039
AASN1041
AHOH1405
BLEU1070

site_idAD2
Number of Residues7
Detailsbinding site for residue EDO A 1311
ChainResidue
AASN1013
AILE1021
AHIS1185
APHE1190
AARG1192
AHOH1431
AHOH1436

site_idAD3
Number of Residues2
Detailsbinding site for residue EDO A 1312
ChainResidue
AARG981
AHOH1450

site_idAD4
Number of Residues4
Detailsbinding site for residue EDO A 1313
ChainResidue
AGLY986
BTRP1081
BPRO1230
BLYS1231

site_idAD5
Number of Residues5
Detailsbinding site for residue EDO A 1314
ChainResidue
AARG1023
AHOH1447
BASN1013
BARG1023
BEDO1308

site_idAD6
Number of Residues5
Detailsbinding site for residue EDO A 1315
ChainResidue
ASER1005
ATYR1007
ATYR1009
AHOH1409
AHOH1461

site_idAD7
Number of Residues15
Detailsbinding site for residue JDG B 1301
ChainResidue
BLYS1055
BTRP1081
BASN1083
BASP1104
BSER1224
BCYS1225
BARG1226
BGLY1228
BSER1229
BCYS1232
BSER1235
BHOH1589
BILE1034
BASP1035
BASP1036

site_idAD8
Number of Residues18
Detailsbinding site for residue JDG B 1302
ChainResidue
BTYR1124
BASP1131
BALA1134
BASP1135
BASP1140
BSER1141
BLEU1143
BASP1145
BVAL1153
BPHE1209
BTYR1211
BARG1214
BPHE1215
BILE1218
BLYS1219
BEDO1313
BHOH1409
BHOH1464

site_idAD9
Number of Residues4
Detailsbinding site for residue ZN B 1303
ChainResidue
BCYS1031
BCYS1033
BCYS1037
BCYS1042

site_idAE1
Number of Residues4
Detailsbinding site for residue ZN B 1304
ChainResidue
BCYS1037
BCYS1074
BCYS1080
BCYS1084

site_idAE2
Number of Residues4
Detailsbinding site for residue ZN B 1305
ChainResidue
BCYS1031
BCYS1044
BCYS1074
BCYS1078

site_idAE3
Number of Residues4
Detailsbinding site for residue ZN B 1306
ChainResidue
BCYS1172
BCYS1225
BCYS1227
BCYS1232

site_idAE4
Number of Residues17
Detailsbinding site for residue SAH B 1307
ChainResidue
BMET1105
BTRP1107
BSER1141
BTYR1142
BARG1166
BPHE1167
BASN1169
BHIS1170
BTYR1211
BPHE1215
BCYS1225
BARG1226
BHOH1438
BHOH1452
BHOH1456
BHOH1585
BHOH1601

site_idAE5
Number of Residues7
Detailsbinding site for residue EDO B 1308
ChainResidue
AEDO1314
BASN1013
BHIS1185
BPHE1190
BARG1192
BHOH1411
BHOH1417

site_idAE6
Number of Residues6
Detailsbinding site for residue EDO B 1309
ChainResidue
BLYS1055
BGLY1220
BLYS1221
BLEU1222
BPHE1223
BHOH1402

site_idAE7
Number of Residues4
Detailsbinding site for residue EDO B 1310
ChainResidue
BSER1005
BTYR1007
BLYS1008
BTYR1009

site_idAE8
Number of Residues6
Detailsbinding site for residue EDO B 1311
ChainResidue
BARG1094
BALA1095
BGLN1113
BPRO1116
BHOH1427
BHOH1586

site_idAE9
Number of Residues4
Detailsbinding site for residue EDO B 1312
ChainResidue
BARG1101
BTHR1102
BARG1103
BGLY1106

site_idAF1
Number of Residues5
Detailsbinding site for residue EDO B 1313
ChainResidue
BPHE1209
BASP1210
BTYR1211
BJDG1302
BHOH1418

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues126
DetailsDomain: {"description":"Pre-SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00157","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues117
DetailsDomain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues25
DetailsRegion: {"description":"Interaction with histone H3"}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues36
DetailsBinding site: {}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues2
DetailsSite: {"description":"Histone H3K9me binding","evidences":[{"source":"PubMed","id":"18264113","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20084102","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

239149

PDB entries from 2025-07-23

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