6MAY
Crystal structure of N-myristoyl transferase (NMT) G386E mutant from Plasmodium vivax
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004379 | molecular_function | glycylpeptide N-tetradecanoyltransferase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0006499 | biological_process | N-terminal protein myristoylation |
A | 0016746 | molecular_function | acyltransferase activity |
A | 0018008 | biological_process | N-terminal peptidyl-glycine N-myristoylation |
B | 0004379 | molecular_function | glycylpeptide N-tetradecanoyltransferase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0006499 | biological_process | N-terminal protein myristoylation |
B | 0016746 | molecular_function | acyltransferase activity |
B | 0018008 | biological_process | N-terminal peptidyl-glycine N-myristoylation |
C | 0004379 | molecular_function | glycylpeptide N-tetradecanoyltransferase activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0006499 | biological_process | N-terminal protein myristoylation |
C | 0016746 | molecular_function | acyltransferase activity |
C | 0018008 | biological_process | N-terminal peptidyl-glycine N-myristoylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 36 |
Details | binding site for residue YNC A 501 |
Chain | Residue |
A | TYR28 |
A | LEU163 |
A | CYS164 |
A | VAL165 |
A | ARG170 |
A | SER171 |
A | LYS172 |
A | ARG173 |
A | LEU174 |
A | ALA175 |
A | PRO176 |
A | LYS29 |
A | THR183 |
A | ILE186 |
A | TRP192 |
A | ALA194 |
A | TYR196 |
A | THR197 |
A | LEU202 |
A | TYR393 |
A | HOH635 |
A | HOH643 |
A | PHE30 |
A | HOH686 |
A | HOH730 |
A | HOH738 |
A | HOH786 |
A | HOH862 |
A | HOH895 |
A | HOH908 |
A | TRP31 |
A | ASN94 |
A | TYR95 |
A | VAL96 |
A | ASN161 |
A | PHE162 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue CL A 502 |
Chain | Residue |
A | LYS180 |
A | THR247 |
A | LEU248 |
A | ARG358 |
A | HOH670 |
site_id | AC3 |
Number of Residues | 3 |
Details | binding site for residue EDO A 503 |
Chain | Residue |
A | GLU159 |
A | TYR337 |
A | VAL408 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue SO4 A 504 |
Chain | Residue |
A | ARG210 |
A | LYS373 |
C | ARG210 |
C | LYS373 |
site_id | AC5 |
Number of Residues | 32 |
Details | binding site for residue YNC B 501 |
Chain | Residue |
B | TYR28 |
B | LYS29 |
B | PHE30 |
B | TRP31 |
B | ASN94 |
B | TYR95 |
B | VAL96 |
B | ASN161 |
B | PHE162 |
B | LEU163 |
B | CYS164 |
B | VAL165 |
B | ARG170 |
B | SER171 |
B | ARG173 |
B | LEU174 |
B | ALA175 |
B | PRO176 |
B | THR183 |
B | ILE186 |
B | TRP192 |
B | GLN193 |
B | ALA194 |
B | TYR196 |
B | THR197 |
B | LEU202 |
B | TYR393 |
B | HOH609 |
B | HOH610 |
B | HOH613 |
B | HOH623 |
B | HOH741 |
site_id | AC6 |
Number of Residues | 4 |
Details | binding site for residue CL B 502 |
Chain | Residue |
B | LYS180 |
B | THR247 |
B | LEU248 |
B | ARG358 |
site_id | AC7 |
Number of Residues | 9 |
Details | binding site for residue EDO B 503 |
Chain | Residue |
B | GLU159 |
B | PHE281 |
B | TRP289 |
B | TYR337 |
B | ILE407 |
B | VAL408 |
B | LEU409 |
B | LEU410 |
B | HOH601 |
site_id | AC8 |
Number of Residues | 27 |
Details | binding site for residue YNC C 501 |
Chain | Residue |
C | VAL96 |
C | PHE162 |
C | LEU163 |
C | CYS164 |
C | VAL165 |
C | ARG170 |
C | ARG173 |
C | LEU174 |
C | ALA175 |
C | PRO176 |
C | THR183 |
C | ILE186 |
C | TRP192 |
C | TYR196 |
C | THR197 |
C | TYR393 |
C | HOH614 |
C | HOH625 |
C | HOH729 |
C | HOH785 |
C | HOH821 |
C | TYR28 |
C | LYS29 |
C | PHE30 |
C | TRP31 |
C | ASN94 |
C | TYR95 |
site_id | AC9 |
Number of Residues | 4 |
Details | binding site for residue CL C 502 |
Chain | Residue |
C | LYS180 |
C | THR247 |
C | LEU248 |
C | ARG358 |
site_id | AD1 |
Number of Residues | 8 |
Details | binding site for residue EDO C 503 |
Chain | Residue |
C | PRO50 |
C | ILE52 |
C | SER53 |
C | ASP54 |
C | ASN55 |
C | TRP192 |
C | GLN193 |
C | HOH770 |
site_id | AD2 |
Number of Residues | 7 |
Details | binding site for residue EDO C 504 |
Chain | Residue |
C | GLU159 |
C | TRP289 |
C | TYR337 |
C | VAL408 |
C | LEU409 |
C | LEU410 |
C | HOH749 |
site_id | AD3 |
Number of Residues | 6 |
Details | binding site for residue SO4 C 505 |
Chain | Residue |
C | ASN120 |
C | LYS257 |
C | LYS259 |
C | HOH605 |
C | HOH663 |
C | HOH766 |
Functional Information from PROSITE/UniProt
site_id | PS00975 |
Number of Residues | 9 |
Details | NMT_1 Myristoyl-CoA:protein N-myristoyltransferase signature 1. EVNFLCvHK |
Chain | Residue | Details |
A | GLU159-LYS167 |