6MAU

Crystal structure of human BRD4(1) in complex with CN210 (compound 19)

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue JBS A 201

Chain	Residue
A	PRO82
A	HOH378
A	PHE83
A	LEU92
A	LEU94
A	ILE138
A	ASN140
A	HOH310
A	HOH315
A	HOH321

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site_id	AC2
Number of Residues	8
Details	binding site for residue GOL A 202

Chain	Residue
A	ILE100
A	ILE101
A	LYS102
A	THR103
A	ASN135
A	ASP145
A	HOH306
A	HOH320

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Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY

Chain	Residue	Details
A	ALA80-TYR139

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Acetylated histone binding => ECO:0000269|PubMed:22464331

Chain	Residue	Details
A	ASN140

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site_id	SWS_FT_FI2
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS99

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