6MA3
Crystal structure of human O-GlcNAc transferase bound to a peptide from HCF-1 pro-repeat 2 (11-26) and inhibitor 2a
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue JAJ A 1101 |
| Chain | Residue |
| A | HIS558 |
| A | ALA896 |
| A | LYS898 |
| A | HIS901 |
| A | ARG904 |
| A | THR921 |
| A | HOH1270 |
| A | HOH1333 |
| A | HOH1353 |
| A | HOH1364 |
| A | HOH1466 |
| A | PRO559 |
| A | HIS562 |
| A | PHE837 |
| A | GLN839 |
| A | LYS842 |
| A | LEU866 |
| A | PHE868 |
| A | VAL895 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000305|PubMed:21240259, ECO:0000305|PubMed:26678539 |
| Chain | Residue | Details |
| A | HIS624 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23103939, ECO:0007744|PDB:4GYW |
| Chain | Residue | Details |
| A | GLU965 | |
| A | ASP968 | |
| A | LYS1022 | |
| A | ILE1027 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by AMPK => ECO:0000269|PubMed:24563466, ECO:0000269|PubMed:37541260 |
| Chain | Residue | Details |
| A | MET570 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | CARBOHYD: O-linked (GlcNAc) serine; by autocatalysis => ECO:0000269|PubMed:27713473 |
| Chain | Residue | Details |
| A | GLU515 |
