6M9C

PSEUDOMONAS SERINE-CARBOXYL PROTEINASE (SEDOLISIN) COMPLEXED WITH THE INHIBITOR Pseudotyrostatin

Replaces:  1KE1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CA A 401

Chain	Residue
A	ASP328
A	VAL329
A	GLY344
A	GLY346
A	ASP348
A	HOH548

---

site_id	AC2
Number of Residues	6
Details	binding site for residue SO4 A 402

Chain	Residue
A	TYR341
A	HOH510
A	HOH619
A	VAL249
A	SER251
A	GLY340

---

site_id	AC3
Number of Residues	5
Details	binding site for residue SO4 A 403

Chain	Residue
A	ASN27
A	GLN148
A	ARG152
A	HOH564
A	HOH693

---

site_id	AC4
Number of Residues	9
Details	binding site for residue SO4 A 404

Chain	Residue
A	SER20
A	ALA22
A	THR24
A	PRO196
A	PRO244
A	TRP246
A	HOH558
A	HOH626
A	HOH715

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ACY A 405

Chain	Residue
A	THR11
A	SER245
A	VAL249
A	HOH774

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ACY A 406

Chain	Residue
A	TRP347
A	HOH519
A	HOH653
A	HOH730

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ACY A 407

Chain	Residue
A	TYR240
A	GLU241
A	HOH501
A	HOH810

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ACY A 408

Chain	Residue
A	ALA211
A	GLY369
A	HOH508
A	HOH773

---

site_id	AC9
Number of Residues	3
Details	binding site for residue ACY A 409

Chain	Residue
A	SER39
A	SER72
A	ASP73

---

Functional Information from PROSITE/UniProt

site_id	PS00138
Number of Residues	11
Details	SUBTILASE_SER Serine proteases, subtilase family, serine active site. GTSlAsPiFVG

Chain	Residue	Details
A	GLY285-GLY295

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	364
Details	Domain: {"description":"Peptidase S53","evidences":[{"source":"PROSITE-ProRule","id":"PRU01032","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	19
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"11323721","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"11747435","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11323721","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11747435","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GA4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NLU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6M8W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6M8Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6M9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6M9D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6M9F","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	4
Details	M-CSA 380

Chain	Residue	Details
A	GLU80	proton shuttle (general acid/base)
A	ASP84	proton shuttle (general acid/base)
A	ASP170	electrostatic stabiliser
A	SER287	covalent catalysis

---