6M8Y

PSEUDOMONAS SERINE-CARBOXYL PROTEINASE (SEDOLISIN) COMPLEXED WITH THE INHIBITOR AIPF

Replaces:  1KDY

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CA A 401

Chain	Residue
A	ASP328
A	VAL329
A	GLY344
A	GLY346
A	ASP348
A	HOH652

---

site_id	AC2
Number of Residues	11
Details	binding site for residue GOL A 402

Chain	Residue
A	THR186
A	LEU273
A	TYR275
A	LEU280
A	HOH501
A	HOH542
A	HOH544
A	HOH557
A	ASN9
A	PHE48
A	ASN52

---

site_id	AC3
Number of Residues	5
Details	binding site for residue GOL A 403

Chain	Residue
A	ALA5
A	ASN221
A	GLU222
A	HOH583
A	HOH599

---

site_id	AC4
Number of Residues	9
Details	binding site for residue GOL A 404

Chain	Residue
A	ASN125
A	VAL126
A	ALA127
A	ASN306
A	HOH508
A	HOH552
A	HOH611
A	HOH752
A	HOH784

---

site_id	AC5
Number of Residues	5
Details	binding site for residue CL A 405

Chain	Residue
A	TRP246
A	HOH738
A	HOH771
A	HOH922
A	HOH928

---

site_id	AC6
Number of Residues	20
Details	binding site for N-acetyl-L-isoleucyl-L-prolyl-L-Phenylalaninal chain B

Chain	Residue
A	ILE35
A	GLU80
A	SER133
A	LEU134
A	GLY135
A	TRP136
A	SER167
A	GLY169
A	ASP170
A	GLU171
A	ARG179
A	SER190
A	GLY285
A	THR286
A	SER287
A	HOH657
A	HOH732
B	HOH401
B	HOH402
B	HOH403

---

Functional Information from PROSITE/UniProt

site_id	PS00138
Number of Residues	11
Details	SUBTILASE_SER Serine proteases, subtilase family, serine active site. GTSlAsPiFVG

Chain	Residue	Details
A	GLY285-GLY295

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	364
Details	Domain: {"description":"Peptidase S53","evidences":[{"source":"PROSITE-ProRule","id":"PRU01032","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	19
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"11323721","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"11747435","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11323721","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11747435","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GA4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NLU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6M8W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6M8Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6M9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6M9D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6M9F","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	4
Details	M-CSA 380

Chain	Residue	Details
A	GLU80	proton shuttle (general acid/base)
A	ASP84	proton shuttle (general acid/base)
A	ASP170	electrostatic stabiliser
A	SER287	covalent catalysis

---